Now showing items 3131-3140 of 3161
Folate Binding Protein as a Therapeutic Natural Nanotechnology
(2018)
Serum proteins interact with small molecules and nanoparticles in blood, resulting in protein coronas. Protein coronas influence the bioidentity of the molecules and nanoparticles, playing critical roles in biotransport, ...
Continuum-Scale Modeling of Rechargeable Batteries
(2020)
During the operation of a rechargeable battery, the electrochemical reactions occur at the interface between the electrolyte and the active material in the electrode. The electrochemical performance of such batteries is ...
Predicting the Formation Pathways and Morphologies of Oxygenated Carbonaceous Nanoparticle Precursors in Premixed Flames
(2017)
Organic nanoparticles are an inevitable by-product of combustion phenomena that have deleterious health and environmental effects. They are carcinogenic because they damage biological cells due to their small size and their ...
A Two-Prong Approach for Targeting the mRNA Cap-Dependent Translation Initiation: Small Molecules and Hydrocarbon Stapled Peptides
(2018)
Cap-dependent protein translation (CdT) is dysregulated in many types of cancer and leads to overexpression of oncogenes promoting angiogenesis, evasion of apoptosis, and cell proliferation. The protein-protein interactions ...
Development of Modular, Droplet Microfluidic Workflows to Investigate Cellular Heterogeneity
(2023)
Cells exist in unique contexts within a population, but miniscule differences in their environment, epigenome, and cell cycle produce an assortment of observable characteristics in cells. Conventional cellular analysis ...
Biological Applications of Surfaces with Extreme Wettabilities
(2019)
Surfaces with extreme wettabilities have become an increasingly popular topic due to their wide range of applications – from simply keeping dirt off clothing to oil-water separation in the event of an oil spill. In particular, ...
Innovations in Droplet Microfluidics for Enzyme Evolution
(2020)
High throughput screening (HTS) is a critical technology in discovery and process chemistry. Typically, HTS has relied on robotic handling of well plates of samples to rapidly perform and assess reactions, but novel ...
Microfluidic Technologies for Bioanalytical Chemistry: Advancing Epigenetic Profiling via Chromatin Immunoprecipitation in Droplets
(2019)
Beyond the linear sequence of the genome, the epigenome dynamically controls chromatin remodeling and transcriptional poise without inducing changes in DNA sequence. These epigenetic mechanisms, particularly modifications ...
Novel Photoarylation-based Controlled Polymerization of Conjugated Polymers and Its Application for Transparent Electrode
(2019)
In order to afford the production of conjugated polymers with uniform and desirable optical and electrical properties on a large scale, much effort have been devoted to light-induced polymerization. Various well-defined ...
Directed Evolution of Stabilized Peptides with Bacterial Display
(2020)
Interactions between proteins govern cellular and the body’s states, including aberrant interactions found in diseases such as in cancers and infections. Small molecule drugs are not ideal in targeting these interactions ...