Now showing items 501-510 of 578
Biological Applications of Surfaces with Extreme Wettabilities
(2019)
Surfaces with extreme wettabilities have become an increasingly popular topic due to their wide range of applications – from simply keeping dirt off clothing to oil-water separation in the event of an oil spill. In particular, ...
Understanding Microencapsulation and Performance of Composition-Equivalent PLGA Microspheres for 1-Month Controlled Release of Leuprolide
(2019)
Poly(lactic-co-glycolic acid) (PLGA) microspheres are the most commonly used and commercially successful long-acting release depots (LARs) for delivery of peptide drugs. However, the approval of generic versions of these ...
Capacity-Demand Relationships in One-Legged Balance: Biomechanical Analyses
(2019)
A common screening test of balance is the timed ability to stand on one leg for as long as possible. A balance time of 5 s or less is an indicator that the patient has an elevated risk for fall-related injuries. But why ...
Using Finite Element Methods to Study Anterior Cruciate Ligament Injuries: Understanding the Role of ACL Modulus and Tibial Surface Geometry on ACL Loading.
(2013)
ACL injury, frequently encountered in sports, results in impaired gameplay, accruement of medical expenses and potential for long-term degenerative disease of the knee. More than 200,000 ACL injuries occur annually with ...
Immunotherapeutic and Diagnostic Potential of Engineered Materials
(2022)
Globally breast cancer has the highest rates of incidence and mortality among women, and the progression of localized breast cancer to metastatic disease is associated with a stark decrease in survival. Although robust ...
Application of Ultra-low Circulating Biomarkers and Single Cell Analysis from Solid Tumors with Single Molecule Resolution
(2020)
Circulating tumor cells (CTCs) and extracellular vesicles (EVs) carry tumor-derived cargo in the circulation and provide the potential for minimally invasive patient monitoring. These circulating biomarkers have both been ...
In Vitro and In Vivo Testing of Ultra-Small Gold Nanoparticles as a Novel Drug Delivery Platform for Enhancing the Brain Penetration and Receptor Binding Affiinity of Central Nervous System Drugs.
(2013)
The endothelial cells of brain capillaries form the so-called blood brain barrier (BBB) which protects the central nervous system (CNS) from the entry of neurotoxins and blood components. Consequently, more than 98% of ...
Injectable Multi-Drug Formulation for the Postoperative Management of Ocular Surgery
(2017)
In this dissertation, the interaction between particles or particles and polymers were examined. In addition, outcomes of such studies were used to develop drug delivery formulations.
Initially, by carrying out Brownian ...
Addressing Challenges in Healthcare Provider Scheduling
(2017)
The goal when solving scheduling problems is to generate a high-quality schedule that satisfies every scheduling requirement. When scheduling healthcare providers, the quality of a schedule is often measured through provider ...
PLGA Depots for Controlled Release of Bevacizumab.
(2016)
The advent of monoclonal antibody (mAb)-based anti-vascular endothelial growth factor (VEGF) therapy for treatment of wet age-related macular degeneration (AMD) has significantly improved the clinical outcomes in patients. ...