Now showing items 511-520 of 578
Multiscale Modeling of T Cells in Mycobacterium Tuberculosis Infection
(2021)
Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (Mtb), is one of the deadliest infectious diseases in the world and remains a significant global health burden. Central to the immune response against ...
Ultrafast Microfluidic Immunoassays Towards Real-time Intervention of Cytokine Storms
(2020)
Biomarker-guided precision medicine holds great promise to provide personalized therapy with a good understanding of the molecular or cellular data of an individual patient. However, implementing this approach in critical ...
Investigating Neuromodulation as a Treatment for Female Sexual Dysfunction
(2020)
Female sexual dysfunction (FSD) affects millions of women worldwide. FSD has a significant impact on quality of life and interpersonal relationships. The prevalence of at least one form of sexual dysfunction is 40-45% of ...
Quantitative Image Reconstruction Methods for Low Signal-To-Noise Ratio Emission Tomography
(2020)
Novel internal radionuclide therapies such as radioembolization (RE) with Y-90 loaded microspheres and targeted therapies labeled with Lu-177 offer a unique promise for personalized treatment of cancer because imaging-based ...
Mechanisms and Engineering of Polymeric Nanoparticles for Modulating Innate and Adaptive Immune Responses
(2019)
The delivery of disease-relevant antigens by nanoparticles is a promising strategy for selectively inhibiting pathogenic autoreactive cells while maintaining a protective immune repertoire. This process, known as ...
Stem Cell-Based Modeling of Early Human Neural Development
(2020)
Neurulation is a key embryonic developmental process that gives rise to the formation of the neural tube (NT), the precursor structure that eventually develops into the central nervous system (CNS). Understanding the ...
Mechanical and Structural Adaptations of Tendon with Aging.
(2014)
Tendon provides a critical functional link between muscle and the skeleton. Thus, any change in tendon mechanical properties with aging may contribute to disability and loss of mobility of the elderly. Despite the importance ...
Microfluidic Technologies for Bioanalytical Chemistry: Advancing Epigenetic Profiling via Chromatin Immunoprecipitation in Droplets
(2019)
Beyond the linear sequence of the genome, the epigenome dynamically controls chromatin remodeling and transcriptional poise without inducing changes in DNA sequence. These epigenetic mechanisms, particularly modifications ...
Characterization of Cerebral Hemodynamics Using a Computational Fluid Dynamics and Arterial Spin Labeling MRI Strategy: Applications in Cerebrovascular Occlusive Disease
(2021)
Cerebrovascular occlusive disease (CVOD) is a major risk factor for ischemic stroke and is characterized by the presence of stenosis in the arteries supplying the brain. The cerebral vasculature has an innate ability to ...
Evaluating the Effects of Powered Prostheses on Walking Biomechanics In and Out of the Lab
(2021)
Powered ankle prostheses aim to replicate the biological ankle function for individuals with transtibial amputation. The effects of powered prostheses on gait have been experimentally quantified in several studies. The ...