Now showing items 521-530 of 578
Modeling Dose-Function Response and Toxicity Pathways in Non-Small Cell Lung Cancer Patients Undergoing Radiation Treatment
(2021)
Radiotherapy is currently the standard of care for treating NSCLC patients, and while technological advancements in the field continue to improve our ability to successfully treat these patients, serious side-effects, i.e. ...
Directed Evolution of Stabilized Peptides with Bacterial Display
(2020)
Interactions between proteins govern cellular and the body’s states, including aberrant interactions found in diseases such as in cancers and infections. Small molecule drugs are not ideal in targeting these interactions ...
Multidisciplinary Study of Soft Shape Morphing Systems
(2021)
Nature abounds with examples of shape morphing systems where an entity either gradually grows into a complex 3-D shape pattern or rapidly morphs into a new configuration. Inspired by the shape shifting capabilities of ...
Identifying Novel Targetable Genes and Pathways in Cancer by Integrating Diverse Omics Data.
(2014)
Omics technologies for high-throughput profiling of human genome, transcriptome and proteome are revolutionizing cancer research and driving a paradigm shift in clinical care, from “one size” fits all treatments to molecularly ...
To Be, or Not to Be: Cellular Homeostasis to Mechanical Perturbations
(2016)
Mechanical homeostasis is an emerging mechanobiology concept that describes the critical biological process to maintain whole-cell/tissue physiology against forces and deformation arising both intra- and extracellularly. ...
Three Essays on Radiotherapy Treatment Planning Optimization
(2017)
Radiation therapy is one of the most common and effective methods of treating cancer. There are two main types: external and internal. External to the patient, a linear accelerator aims beams of radiation toward the ...
Human Skeletal Muscle Units for the Repair of Volumetric Muscle Loss
(2022)
Volumetric muscle loss (VML) is a common pathological condition caused by traumatic loss of skeletal muscle that exceeds the muscle’s regenerative capabilities and results in functional impairment. Current standards-of-care ...
Mechanotransduction in Breast and Ovarian Cancers: Using Bioreactors to Study the Cellular Response to Physiological Mechanical Stimuli
(2020)
Cells within the body experience a wide range of dynamic mechanical stimuli. These stimuli are exacerbated in cancers and can alter the progression of the disease. As the tumor grows and expands, it presses out against the ...
Understanding the Solution Phase Chemistry and Solid State Thermodynamic Behavior of Pharmaceutical Cocrystals.
(2012)
This dissertation focuses on the thermodynamic stability and solubility of pharmaceutical cocrystals. Specifically, the objectives are to; (i) investigate the influence of coformer properties such as solubility and ionization ...
Evaluating Optimality in the Control of Wearable Robotic Devices
(2021)
Lower-limb wearable robots, such as prostheses and exoskeletons, have the potential to fundamentally transform the mobility of millions of able-bodied and disabled individuals during work, recreation, and/or rehabilitation. ...