Now showing items 551-560 of 578
Construction of Engineered Nanoparticles with Tailored Densities of Self-Antigen for the Study of B-cell Activation
(2019)
Epitope density appears to be a critical factor in pathogens that can elicit effective immune responses. All the viruses that have efficacious FDA-approved target vaccines have high surface densities of antigens. HIV, on ...
Biomechanical Adaptations to Lower Limb Amputation during Functional Mobility Tasks
(2022)
People with a unilateral transtibial amputation (TTA) complete functional tasks asymmetrically, using compensatory strategies to accommodate for the lost ankle muscle function. These strategies may contribute the greater ...
Optimization and Simulation of Kidney Paired Donation Programs.
(2012)
An evolving strategy known as kidney paired donation (KPD) matches one donor-candidate pair to another pair with a complementary incompatibility,
such that the donor of the first pair donates to the candidate of the second, ...
Development of Functional Bioengineered Muscle Models and a Novel Micro-Perfusion System.
(2008)
Tissue engineering combines the principles of medical, life science, and engineering fields toward the development of biological substitutes to restore, maintain, or improve tissue function. Previous work has demonstrated ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
Perfusion Estimation in Volumetric Imaging of Ultrasound Contrast Agents.
(2009)
This dissertation presents research involving the investigation of perfusion measured using volumetric imaging of ultrasound contrast agents. Ultrasound contrast agents are micrometer-sized gas bubbles that track the blood ...
Nanochemistry for Biomedical Sensors and Contrast Agents.
(2008)
The primary focus of the work described in this dissertation is the coupling of PEBBLE (Photonic Explorers for Biomedical use by Biologically Localized Embedding) nanosensors with new sensing technologies.
Included in ...
Ultrasound-triggered Drug Delivery Using Acoustic Droplet Vaporization.
(2010)
The goal of targeted drug delivery is the spatial and temporal localization of a therapeutic agent and its associated bioeffects. One method of drug localization is acoustic droplet vaporization (ADV), whereby drug-laden ...
Molecular Dynamics Simulation of Phase and Structural Transitions in Model Lung Surfactant Mixtures.
(2010)
Lung surfactant (LS) is a complex mixture of lipids and proteins that reduces and regulates the surface tension in the lungs, thereby decreasing the work of breathing. A thorough understanding of LS function is critical ...
Design and Evaluation of Elastic Exoskeletons for Human Running
(2010)
Humans bounce along the ground when they hop and run, providing spring-like function with their muscles and tendons. Compliant elastic mechanisms could assist this motion by contributing additional elastic storage and ...