Now showing items 41-50 of 184
Mapping the human amylase gene cluster on the proximal short arm of chromosome 1 using a highly informative (CA)n repeat
(Elsevier, 1990-05)
The human amylase gene cluster includes a (CA)n repeat sequence immediately upstream of the [gamma]-actin pseudogene associated with the AMY2B gene. Analysis of this (CA)n repeat by PCR amplification of genomic DNA from ...
Application of an ordered subset analysis approach to the genetics of alcoholism
(Wiley Subscription Services, Inc., A Wiley Company, 1999)
For complex diseases, underlying etiologic heterogeneity may reduce power to detect linkage. Thus, methods to identify more homogeneous subgroups within a given sample in a linkage study may improve detection of putative ...
Localization of a human T-cell-specific gene, RANTES (D17S136E), to chromosome 17q11.2-q12
(Elsevier, 1990-03)
We report here the localization of the gene for a human T-cell-specific molecule, designated RANTES, to human chromosome region 17q11.2-q12 by in situ hybridization and analysis of somatic cell hybrids using a cDNA probe ...
Conserved Linkage of Early Growth Response 4, Annexin 4, and Transforming Growth Factor [alpha] on Mouse Chromosome 6
(Elsevier, 1994-01-15)
The mouse genes encoding early growth response 4 (Egr4), annexin IV (Anx4), and transforming growth factor a (Tgfa) have been mapped to a linkage group on mouse chromosome 6 that is conserved on human chromosome 2p11-p13. ...
Human PCK1 Encoding Phosphoenolpyruvate Carboxykinase Is Located on Chromosome 20q13.2
(Elsevier, 1993-01)
Cytoplasmic liver phosphoenolpyruvate carboxykinase (GTP)(PEPCK) catalyzes a rate-limiting step in gluconeogenesis. Primers derived from the rat liver PEPCK sequence were used to amplify a portion of the human liver cDNA ...
Structure and chromosomal localization of the human thrombospondin gene
(Elsevier, 1990-04)
Thrombospondin (THBS1) is a large modular glycoprotein component of the extracellular matrix and contains a variety of distinct domains, including three repeating subunits (types I, II, and III) that share homology to an ...
Prenatal diagnosis and linkage disequilibrium with cystic fibrosis for markers surrounding D7S8
(Springer-Verlag, 1990-08)
Three polymorphic DNA markers surrounding the D7S8 locus were tested for their usefulness in the diagnosis of cystic fibrosis (CF) by linkage analysis. The markers correspond to the loci D7S424 and D7S426. These polymorphisms ...
Genetic and Physical Map of 11 Short Tandem Repeat Polymorphisms on Human Chromosome 6
(Elsevier, 1993-01)
A linkage map of 11 short tandem repeat polymorphisms was constructed for human chromosome 6. The order from p to qter was F131-D6S105-D6S254-D6S251-D6S252-D6S249-(ARG1-D6S87)-D6S250-D6S255-D6S253. For the region spanned ...
Neural retina-specific leucine zipper gene NRL (D14S46E) maps to human chromosome 14q11.1-q11.2
(Elsevier, 1992-10)
The product of a neural retina-specific gene, NRL, belongs to the "leucine zipper" family of DNA-binding proteins and has a strong similarity to the v-maf oncogene product. The NRL gene maps to human chromosome 14 by ...
Phosphoenolpyruvate Carboxykinase (GTP): Characterization of the Human PCK1 Gene and Localization Distal to MODY on Chromosome 20
(Elsevier, 1993-06)
The human PCK1 gene encoding phosphoenolpyruvate carboxykinase (GTP) (PEPCK) was isolated and sequenced. There is 91% amino acid sequence identity (567/622 residues) between the human and the rat proteins, with conservation ...