Now showing items 91-100 of 133
Transgenic Zebrafish for Studying Nervous System Development and Regeneration
(Kluwer Academic Publishers-Plenum Publishers; Kluwer Academic Publishers ; Springer Science+Business Media, 2001-02)
α1 tubulin gene expression is induced in the developing and regenerating CNS of vertebrates. Therefore, α1 tubulin gene expression may serve as a good probe for mechanisms underlying CNS development and regeneration. One ...
Selective Breeding for Divergence in Novelty-seeking Traits: Heritability and Enrichment in Spontaneous Anxiety-related Behaviors
(Kluwer Academic Publishers-Plenum Publishers; Springer Science+Business Media, Inc., 2006-02-24)
Outbred Sprague–Dawley rats can be classified as high responders (HR) or low responders (LR) based on their levels of exploratory locomotion in a novel environment. While this novelty-seeking dimension was originally related ...
Two-locus genome-wide linkage scan for prostate cancer susceptibility genes with an interaction effect
(Springer-Verlag, 2006-02)
Prostate cancer represents a significant worldwide public health burden. Epidemiological and genetic epidemiological studies have consistently provided data supporting the existence of inherited prostate cancer susceptibility ...
Shrinkage estimation for robust and efficient screening of single-SNP association from case-control genome-wide association studies
(Wiley Subscription Services, Inc., A Wiley Company, 2009-12)
Population-based case-control design has become one of the most popular approaches for conducting genome-wide association scans for rare diseases like cancer. In this article, we propose a novel method for improving the ...
Gender- and age-specific contributions of additional DNA sequence variation in the 5′ regulatory region of the APOE gene to prediction of measures of lipid metabolism
(Springer-Verlag, 2004-09)
In the present study of 9,000 individuals representative of the general population, we have considered whether the addition of common single nucleotide polymorphisms (SNPs) in the promoter region of Apolipoprotein E ( APOE ...
Improved score statistics for meta‐analysis in single‐variant and gene‐level association studies
(Princeton University PressWiley Periodicals, Inc., 2018-06)
Meta‐analysis is now an essential tool for genetic association studies, allowing them to combine large studies and greatly accelerating the pace of genetic discovery. Although the standard meta‐analysis methods perform ...
Quantifying and correcting for the winner's curse in genetic association studies
(Wiley Subscription Services, Inc., A Wiley Company, 2009-07)
Genetic association studies are a powerful tool to detect genetic variants that predispose to human disease. Once an associated variant is identified, investigators are also interested in estimating the effect of the ...
Sparse multivariate factor analysis regression models and its applications to integrative genomics analysis
(SpringerWiley Periodicals, Inc., 2017-01)
The multivariate regression model is a useful tool to explore complex associations between two kinds of molecular markers, which enables the understanding of the biological pathways underlying disease etiology. For a set ...
The DNA damage response—Repair or despair?
(Wiley Subscription Services, Inc., A Wiley Company, 2010-10)
The term “the DNA damage response” (DDR) encompasses a sophisticated array of cellular initiatives set in motion as cells are exposed to DNA-damaging events. It has been known for over half a century that all organisms ...