Now showing items 11-20 of 133
Genome‐Wide Family‐Based Linkage Analysis of Exome Chip Variants and Cardiometabolic Risk
(Wiley Periodicals, Inc., 2014-04)
Linkage analysis of complex traits has had limited success in identifying trait‐influencing loci. Recently, coding variants have been implicated as the basis for some biomedical associations. We tested whether coding ...
Methods for meta‐analysis of multiple traits using GWAS summary statistics
(Oxford University PressWiley Periodicals, Inc., 2018-03)
Genome‐wide association studies (GWAS) for complex diseases have focused primarily on single‐trait analyses for disease status and disease‐related quantitative traits. For example, GWAS on risk factors for coronary artery ...
Understanding the accuracy of statistical haplotype inference with sequence data of known phase
(Wiley Subscription Services, Inc., A Wiley Company, 2007-11)
Statistical methods for haplotype inference from multi-site genotypes of unrelated individuals have important application in association studies and population genetics. Understanding the factors that affect the accuracy ...
Rederivation of Transgenic and Gene-Targeted Mice by Embryo Transfer
(Kluwer Academic Publishers-Plenum Publishers; Kluwer Academic Publishers ; Springer Science+Business Media, 2004-08)
Research on genetically engineered mice provides insights into the etiology, therapy, and genetic basis of human diseases. An important variable that affects the results of mouse studies is the health status of the animals. ...
Identifying Plausible Genetic Models Based on Association and Linkage Results: Application to Type 2 Diabetes
(Cambridge University PressWiley Periodicals, Inc., 2012-12)
Genome-wide linkage scan for prostate cancer susceptibility genes in men with aggressive disease: significant evidence for linkage at chromosome 15q12
(Springer-Verlag, 2006-05)
Epidemiological and twin studies have consistently demonstrated a strong genetic component to prostate cancer (PCa) susceptibility. To date, numerous linkage studies have been performed to identify chromosomal regions ...
Estimating the power of variance component linkage analysis in large pedigrees
(Wiley Subscription Services, Inc., A Wiley Company, 2006-09)
Variance component linkage analysis is commonly used to map quantitative trait loci (QTLs) in general pedigrees. Large pedigrees are especially attractive for these studies because they provide greater power per genotyped ...
A comparison study of multivariate fixed models and Gene Association with Multiple Traits (GAMuT) for nextâ generation sequencing
(John Wiley & Sons, 2017-01)
In this paper, extensive simulations are performed to compare two statistical methods to analyze multiple correlated quantitative phenotypes: (1) approximate Fâ distributed tests of multivariate functional linear models ...
Improving estimates of genetic maps: a meta-analysis-based approach
(Wiley Subscription Services, Inc., A Wiley Company, 2007-07)
Inaccurate genetic ( or linkage ) maps can reduce the power to detect linkage, increase type I error, and distort haplotype and relationship inference. To improve the accuracy of existing maps, I propose a meta-analysis-based ...
Development of adenovirus immobilization strategies for in situ gene therapy
(John Wiley & Sons, Ltd., 2008-10)
Background Regenerative gene therapy using viral vectors enables transduced cells to express bioactive factors in vivo . Viral delivery with spatial control can enhance transduction efficiency and may limit systemic ...