Now showing items 31-40 of 338
Systemic lupus erythematosus in a man with Noonan syndrome
(John Wiley & Sons, Inc., 2001-07-22)
Noonan syndrome is a multiple congenital anomaly condition characterized by craniofacial anomalies, short stature, cardiac malformations, and normal peripheral blood karyotype analysis. Prior reports of individuals with ...
Integrin alpha V beta 3 targeted dendrimer‐rapamycin conjugate reduces fibroblast‐mediated prostate tumor progression and metastasis
(Wiley Periodicals, Inc., 2018-11)
Therapeutic strategies targeting both cancer cells and associated cells in the tumor microenvironment offer significant promise in cancer therapy. We previously reported that generation 5 (G5) dendrimers conjugated with ...
Mer Tyrosine Kinase Regulates Disseminated Prostate Cancer Cellular Dormancy
(Wiley Periodicals, Inc., 2017-04)
Many prostate cancer (PCa) recurrences are thought to be due to reactivation of disseminated tumor cells (DTCs). We previously found a role of the TAM family of receptor tyrosine kinases TYRO3, AXL, and MERTK in PCa dormancy ...
A comparison study of multivariate fixed models and Gene Association with Multiple Traits (GAMuT) for nextâ generation sequencing
(John Wiley & Sons, 2017-01)
In this paper, extensive simulations are performed to compare two statistical methods to analyze multiple correlated quantitative phenotypes: (1) approximate Fâ distributed tests of multivariate functional linear models ...
Improving estimates of genetic maps: a meta-analysis-based approach
(Wiley Subscription Services, Inc., A Wiley Company, 2007-07)
Inaccurate genetic ( or linkage ) maps can reduce the power to detect linkage, increase type I error, and distort haplotype and relationship inference. To improve the accuracy of existing maps, I propose a meta-analysis-based ...
Development of adenovirus immobilization strategies for in situ gene therapy
(John Wiley & Sons, Ltd., 2008-10)
Background Regenerative gene therapy using viral vectors enables transduced cells to express bioactive factors in vivo . Viral delivery with spatial control can enhance transduction efficiency and may limit systemic ...
Generation of Phenylpropanoid Pathway-Derived Volatiles in Transgenic Plants: Rose Alcohol Acetyltransferase Produces Phenylethyl Acetate and Benzyl Acetate in Petunia Flowers
(Kluwer Academic Publishers; Springer, 2006-03)
Esters are important contributors to the aroma of numerous flowers and fruits. Acetate esters such as geranyl acetate, phenylethyl acetate and benzyl acetate are generated as a result of the action of alcohol acetyltransferases ...
Pleiotropy Analysis of Quantitative Traits at Gene Level by Multivariate Functional Linear Models
(John Wiley & Sons, 2015-05)
In genetics, pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits. A common approach is to analyze the phenotypic traits separately using univariate analyses and combine the test results ...
Extent and distribution of linkage disequilibrium in the Old Order Amish
(Wiley Subscription Services, Inc., A Wiley Company, 2010-02)
Knowledge of the extent and distribution of linkage disequilibrium (LD) is critical to the design and interpretation of gene mapping studies. Because the demographic history of each population varies and is often not ...
Robust meta‐analysis of biobank‐based genome‐wide association studies with unbalanced binary phenotypes
(Wiley Periodicals, Inc.Prentice‐Hall, 2019-07)
With the availability of large‐scale biobanks, genome‐wide scale phenome‐wide association studies are being instrumental in discovering novel genetic variants associated with clinical phenotypes. As increasing number of ...