Now showing items 4981-4990 of 5057
Sugar Silanes in Carbohydrate Synthesis: Applications Towards Site-Selective Glycosylation.
(2011)
Despite numerous elegant advances in the formation of O-glycosides, many opportunities for improvement still remain. The site-selective incorporation of glycosides into complex polyfunctional molecules, as well as the need ...
The Development of Reactions for the Stereoselective Synthesis of Heterocycles and Benzylic Amines, and Exploration of Bisisoxazolidines as Small Molecule Transcriptional Activation Domains.
(2011)
Chapter 1 provides a brief introduction. Chapters 2 and 3 of this thesis describe the development new methods for the synthesis of nitrogen containing heterocycles via palladium catalyzed carboamination reactions. The ...
Catalyst Controlled Site-Selective C-H Functionalization.
(2012)
The development of mild and selective methods for the functionalization of arene C-H bonds remains an important challenge in organic chemistry. One strategy to achieve this goal is metal-catalyzed C-H functionalization. ...
Understanding and Developing PikC as a Tool in Organic Synthesis. Part I: Total Synthesis of Methymycin and Neomethymycin Featuring a Catalytic Nickel Ynal Cyclization and a Biocatalytic PikC CH Oxidation. Part II: Regiodivergent Nickel Catalyzed Macrocyc
(2012)
Organic synthesis has been revolutionized by the widespread adoption of organometallic chemistry. Laboratories lacking specialized expertise in transition metals routinely carry out transformations once deemed impossible ...
Development and Characterization of Microscale Samplers Coupled to HPLC for Near Real-Time Reaction Monitoring
(2010)
The ability to sample a chemical reaction mixture on-line and on a continuous basis can lead to a better understanding of the chemical process, resulting in improved yield and quality of product. This is particularly ...
Palladium-Catalyzed Cyclopropanation Reactions and Site Selectivity in Palladium-Catalyzed Oxidative Cross-Coupling Reactions.
(2011)
This thesis describes our efforts at the discovery, optimization, and mechanistic study of two new and fundamentally different Pd–mediated reactions for the construction of bicyclic cyclopropanes as well as biaryl products. ...
Experimental Studies and Numerical Simulations on Light-Harvesting Devices.
(2010)
Obtaining high solar energy conversion efficiencies with materials that require minimal processing or refining is critical to next generation light-harvesting systems. Organic dyes and inorganic nanostructured semiconductors ...
Atomic-Level Dynamical, Structural and Functional Investigation of a Membrane Protein Complex through Nuclear Magnetic Resonance Spectroscopy.
(2011)
Biological cell membranes are vital boundaries that separate the intracellular elements from the extracellular environments, and they are fundamental regulators of a number of cellular and physiological phenomena. In fact, ...
In Vivo Neurochemical Monitoring with High Temporal and Spatial Resolution using Segmented Flow Microfluidics.
(2011)
Monitoring the concentration dynamics of neurochemicals in the brain is a key tool in the effort to understand brain function, diseases, and treatments. A versatile and effective approach for in vivo monitoring of chemical ...
NetCellMatch: Multiscale Network-Based Matching of Cancer Cell Lines to Patients Using Graphical Wavelets
(Wiley Periodicals, Inc., 2022-12)
Cancer cell lines serve as model in vitro systems for investigating therapeutic interventions. Recent advances in high-throughput genomic profiling have enabled the systematic comparison between cell lines and patient tumor ...