Now showing items 1-10 of 57
Rho/MRTF Pathway Signaling and Small-Molecule Inhibitor Development in Systemic Sclerosis and Metastatic Melanoma
(2015)
Rho GTPases regulate multiple biological functions; most notably, they stimulate formation of F-actin stress fiber formations. Through their modulation of the actin cytoskeleton Rho GTPases also activate gene transcription ...
Regulation of Human Hsp70 by its Nucleotide Exchange Factors (NEFs).
(2015)
Heat shock protein 70 (Hsp70) is an abundant and ubiquitous molecular chaperone that is responsible for maintenance of the human proteome. Accordingly, Hsp70 has become an attractive drug target for neurodegenerative and ...
Pleiotropy Analysis of Quantitative Traits at Gene Level by Multivariate Functional Linear Models
(John Wiley & Sons, 2015-05)
In genetics, pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits. A common approach is to analyze the phenotypic traits separately using univariate analyses and combine the test results ...
Artifact‐Free Quantification and Sequencing of Rare Recombinant Viruses by Using Drop‐Based Microfluidics
(Wiley Periodicals, Inc., 2015-10)
Recombination is an important driver in the evolution of viruses and thus is key to understanding viral epidemics and improving strategies to prevent future outbreaks. Characterization of rare recombinant subpopulations ...
Assessing microbial competition in a hydrogen‐based membrane biofilm reactor (MBfR) using multidimensional modeling
(Cambridge University PressWiley Periodicals, Inc., 2015-09)
The membrane biofilm reactor (MBfR) is a novel technology that safely delivers hydrogen to the base of a denitrifying biofilm via gas‐supplying membranes. While hydrogen is an effective electron donor for denitrifying ...
Increase in mercury in Pacific yellowfin tuna
(University of California PressWiley Periodicals, Inc., 2015-04)
Mercury is a toxic trace metal that can accumulate to levels that threaten human and environmental health. Models and empirical data suggest that humans are responsible for a great deal of the mercury actively cycling in ...
Microplastics: addressing ecological risk through lessons learned
(Wiley Periodicals, Inc.Butterworth‐Heinemann Elsevier, 2015-05)
Plastic litter is an environmental problem of great concern. Despite the magnitude of the plastic pollution in our water bodies, only limited scientific understanding is available about the risk to the environment, ...
Identification of FAK substrate peptides via colorimetric screening of a one‐bead one‐peptide combinatorial library
(Wiley Periodicals, Inc., 2015-04)
Antitumor effector B cells directly kill tumor cells via the Fas/FasL pathway and are regulated by IL‐10
(Wiley Periodicals, Inc., 2015-04)