Now showing items 1-10 of 88
An Antibiotic Discovery Campaign Targeting VirF, the Main Transcriptional Regulator of Virulence in Shigella flexneri
(2016)
Shigella flexneri is a gram-negative enteropathogen that infects the human colonic epithelium. It is estimated that Shigella spp. infect 165 million people a year worldwide. Symptoms of shigellosis include bloody dysentery, ...
Designing Thermal Modulators for Portable GC x GC Systems.
(2015)
Microelectromechanical systems (MEMS) have the advantage of scale and can be manufactured in bulk. One of the active areas of MEMS research is the development of micro-scale comprehensive two-dimensional gas chromatography ...
Vibrational Probe and Methods Development for Studying the Ultrafast Dynamics of Preferential Solvation of Biomolecules by 2D-IR.
(2015)
Over the last decade two-dimensional infrared spectroscopy (2D-IR) has emerged as a powerful method for the investigation of biological samples and their dynamics. Through the implementation of state of the art signal ...
A NMR Investigation of Structure and Allostery in the Hsp70 Chaperone System.
(2010)
The Hsp70 Chaperone system is a complex molecular machine composed of proteins. It is responsible for assisting in protein folding/refolding/processing and transport. Hsp70 proteins have been historically associated with ...
Structural Characterization and Impedance Spectroscopy of Substituted, Fused-Ring Organic Semiconductors.
(2011)
Organic materials present a number of advantages over silicon that make them ideal candidates for modest performance devices like active matrix backplanes and RFID tags. The work detailed here describes both structural ...
In Situ Polymerization via an Environmentally-borne Initiation Stimulus.
(2016)
The utilization of an environmentally-borne stimulus, atmospheric oxygen, has been convincingly demonstrated as a useful means for initiating in situ polymerization. As molecular oxygen is both ubiquitous and capable of ...
Plasma Discharges in Gas Bubbles in Liquid Water: Breakdown Mechanisms and Resultant Chemistry.
(2015)
The use of atmospheric pressure plasmas in gases and liquids for purification of liquids has been investigated by numerous researchers, and is highly attractive due to their strong potential as a disinfectant and sterilizer. ...
Disruption of Endosomal Membrane by Cationic Vectors Drives Endosomal Release and Enables Successful Gene Delivery
(2016)
The potential of gene therapy to treat congenital disorders is hindered by the lack of safe and effective delivery agents (vectors). More effective viral vectors possess several safety concerns but the safer non-viral ...
Design, Synthesis and Biological Evaluation of Non-Peptidic Small Molecular SMAC Mimetics as Potent IAP Inhibitors.
(2008)
The resistance of tumor cells to apoptosis is a major problem in current cancer therapies. Successful anticancer strategies would benefit from specific targeting of the pathways that cause the resistance. Hence, targeting ...
Targeting the BCL9/B9L Binding Interaction with B-catenin as a Potential Anticancer Strategy.
(2010)
Wnt signaling plays a critical role in numerous cellular processes including embryonic development, cell proliferation and tissue homeostasis. The multifunctional protein β-catenin is the primary mediator of canonical Wnt ...