Now showing items 1-10 of 154
Characterization of microRNA-Protein Interactions and Genome-Scale Screening for Modifiers of LDL Cholesterol Uptake
(2020)
MicroRNAs (miRNAs) are small noncoding RNAs that regulate protein expression via post-transcriptional silencing of target genes. These small RNAs are implicated in the regulation of nearly all biological processes, and ...
On Demand Light‐Degradable Polymers Based on 9,10‐Dialkoxyanthracenes
(Wiley Periodicals, Inc., 2020-08)
Light induced degradation of polymers has drawn increasing interest due to the need for externally controllable modulation of materials properties. However, the portfolio of polymers, that undergo precisely controllable ...
Cover Feature: Flavin‐Dependent Monooxygenases NotI and NotI′ Mediate Spiro‐Oxindole Formation in Biosynthesis of the Notoamides (ChemBioChem 17/2020)
(Wiley Periodicals, Inc., 2020-09-01)
Flavin‐Dependent Monooxygenases NotI and NotI′ Mediate Spiro‐Oxindole Formation in Biosynthesis of the Notoamides
(Wiley Periodicals, Inc., 2020-09-01)
The fungal indole alkaloids are a unique class of complex molecules that have a characteristic bicyclo[2.2.2]diazaoctane ring and frequently contain a spiro‐oxindole moiety. While various strains produce these compounds, ...
Neutralization of IL- 10 produced by B cells promotes protective immunity during persistent HCV infection in humanized mice
(Wiley Periodicals, Inc., 2020-09)
Chronic HCV infection can lead to cirrhosis and is associated with increased mortality. Interleukin (IL)- 10- producing B cells (B10 cells) are regulatory cells that suppress cellular immune responses. Here, we aimed to ...
Enzyme Scaffolds with Hierarchically Defined Properties via 3D Jet Writing
(Wiley Periodicals, Inc.Millersville, PA, 2020-09)
The immobilization of enzymes into polymer hydrogels is a versatile approach to improve their stability and utility in biotechnological and biomedical applications. However, these systems typically show limited enzyme ...
Stereoselective β‐Mannosylation via Anomeric O‐Alkylation with L‐Sugar‐Derived Electrophiles
(Wiley Periodicals, Inc., 2021-12-28)
A total synthesis of the trisaccharide repeat unit of Salmonella serogroup E1 O‐antigen is reported. This synthesis features a key β‐mannosylation reaction through a cesium carbonate‐mediated anomeric O‐alkylation of a ...
Spatial arrangement of proteins in planar and curved membranes by PPM 3.0
(John Wiley & Sons, Inc., 2022-01)
Cellular protrusions, invaginations, and many intracellular organelles have strongly curved membrane regions. Transmembrane and peripheral membrane proteins that induce, sense, or stabilize such regions cannot be properly ...
Protein inter- residue contact and distance prediction by coupling complementary coevolution features with deep residual networks in CASP14
(John Wiley & Sons, Inc., 2021-12)
This article reports and analyzes the results of protein contact and distance prediction by our methods in the 14th Critical Assessment of techniques for protein Structure Prediction (CASP14). A new deep learning- based ...