Now showing items 1-10 of 12
Isolation, Expansion and Characterization of Circulating Tumor Cells using Microfluidic Technologies.
(2016)
Circulating tumor cells (CTCs) are the tumor cells shed from primary tumor, which enter the bloodstream and travel to distant anatomic sites to form metastasis. Detecting CTCs, as a means of “liquid biopsy”, allows monitoring ...
Quantum Inspired Machine Learning Algorithms for Adaptive Radiotherapy
(2021)
Adaptive radiotherapy (ART) refers to the modification of radiotherapy treatment plans in response to patient anatomical and physiological changes over the course of treatment and has been recognized as an important step ...
Targeting Branched Chain Amino Acid Metabolism in Tumor Microenvironment
(2020)
Branched Chain amino acids (BCAAs) play an essential role in cell metabolism supplying both carbon and nitrogen in pancreatic cancers, and their increased levels have been associated with increased risk of pancreatic ductal ...
Immunotherapeutic and Diagnostic Potential of Engineered Materials
(2022)
Globally breast cancer has the highest rates of incidence and mortality among women, and the progression of localized breast cancer to metastatic disease is associated with a stark decrease in survival. Although robust ...
Application of Ultra-low Circulating Biomarkers and Single Cell Analysis from Solid Tumors with Single Molecule Resolution
(2020)
Circulating tumor cells (CTCs) and extracellular vesicles (EVs) carry tumor-derived cargo in the circulation and provide the potential for minimally invasive patient monitoring. These circulating biomarkers have both been ...
Injectable Multi-Drug Formulation for the Postoperative Management of Ocular Surgery
(2017)
In this dissertation, the interaction between particles or particles and polymers were examined. In addition, outcomes of such studies were used to develop drug delivery formulations.
Initially, by carrying out Brownian ...
Ultrafast Microfluidic Immunoassays Towards Real-time Intervention of Cytokine Storms
(2020)
Biomarker-guided precision medicine holds great promise to provide personalized therapy with a good understanding of the molecular or cellular data of an individual patient. However, implementing this approach in critical ...
Modeling Dose-Function Response and Toxicity Pathways in Non-Small Cell Lung Cancer Patients Undergoing Radiation Treatment
(2021)
Radiotherapy is currently the standard of care for treating NSCLC patients, and while technological advancements in the field continue to improve our ability to successfully treat these patients, serious side-effects, i.e. ...
Identifying Novel Targetable Genes and Pathways in Cancer by Integrating Diverse Omics Data.
(2014)
Omics technologies for high-throughput profiling of human genome, transcriptome and proteome are revolutionizing cancer research and driving a paradigm shift in clinical care, from “one size” fits all treatments to molecularly ...
Three Essays on Radiotherapy Treatment Planning Optimization
(2017)
Radiation therapy is one of the most common and effective methods of treating cancer. There are two main types: external and internal. External to the patient, a linear accelerator aims beams of radiation toward the ...