Now showing items 21-30 of 2145
Contribution of Renal and Non‐Renal Clearance on Increased Total Clearance of Adalimumab in Glomerular Disease
(Wiley Periodicals, Inc., 2013-09)
The contribution of renal and non‐renal clearance toward targeted concentrations and/or effects of therapeutic proteins in nephrotic patients are unknown. This study dissected the contribution of clearance pathways to ...
Comparison of in vitro – in vivo extrapolation of biliary clearance using an empirical scaling factor versus transport‐based scaling factors in sandwich‐cultured rat hepatocytes
(Wiley Subscription Services, Inc., A Wiley Company, 2013-08)
Biliary clearance (CL b ) is often underestimated by in vitro – in vivo extrapolation from sandwich‐cultured hepatocytes (SCHs). The objective of this study was to compare the performance of a universal correction factor ...
Successfully Accelerating Translational Research at an Academic Medical Center: The University of Michigan-Coulter Translational Research Partnership Program
(Blackwell Publishing Inc, 2010-12)
Translational research encompasses the effective movement of new knowledge and discoveries into new approaches for prevention, diagnosis, and treatment of disease. There are many roadblocks to successful bench to bedside ...
Improved Targeting and Biopharmaceutical Properties of Prodrugs of Anti-infective Agents.
(2013)
The prodrug strategy has been frequently used as a chemical approach for the enhancement of certain disadvantages of parent drugs. In this dissertation, I synthesized prodrugs of two anti-infective agents, ganciclovir and ...
Drug‐like Leads for Steric Discrimination between Substrate and Inhibitors of Human Acetylcholinesterase
(Blackwell Publishing LtdWiley Periodicals, Inc., 2011-10)
Human Jejunal Permeability of Two Polar Drugs: Cimetidine and Ranitidine
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2001-06)
Purpose . To determine the human jejunal permeability of cimetidine and ranitidine using a regional jejunal perfusion approach, and to integrate such determinations with previous efforts to establish a baseline correlation ...
Biopharmaceutics Classification System: The Scientific Basis for Biowaiver Extensions
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2002-07)
Allostery at opioid receptors: modulation with small molecule ligands
(John Wiley & Sons, Ltd, 2018-07)
Acute inhibition of nitric oxide exacerbates airway hyperresponsiveness, eosinophilia and C-C chemokine generation in a murine model of fungal asthma
(Birkhäuser Verlag; Birkhäuser Verlag, ; Springer Science+Business Media, 2000-06)
Objective and Design: This study examined he role of nitric oxide in changes in airway physiology and inflammation in a murine model of fungal allergy induced by Aspergillus fumigatus (A. fumigatus) by treatment of A. ...
Mechanistic investigation of food effect on disintegration and dissolution of BCS class III compound solid formulations: the importance of viscosity
(Wiley Periodicals, Inc., 2012-10)
A negative food effect, i.e. a decrease in bioavailability upon the co‐administration of compounds together with food, has been attributed particularly with high solubility/low permeability compounds (BCS class III). ...