Now showing items 3401-3410 of 3410
Guardianship: A medicolegal review for clinicians
(John Wiley & Sons, Inc., 2022-11)
Guardianship may pose an ethical dilemma for physicians, who must balance protecting vulnerable patients from potential safety concerns with respecting their autonomy. Older adults with dementia are particularly susceptible ...
Summary and conclusions, and abbreviations and acronyms
(Wiley Periodicals, Inc., 2022-12)
Pronounced squamous cell contamination in biliary tract cytology: A diagnostic pitfall
(John Wiley & Sons, Inc., 2022-11)
Squamous cells are rarely found in biliary tract cytology specimens, and when present are typically scant in quantity. Over an 8-year time period, two cases at our institution reporting abundant squamous cells were identified. ...
The Role of Mechanosensitive Calcium Signaling in Remodeling of Epithelial Cell-Cell Junctions
(2021)
Epithelial cells line most of our body cavities, separating different compartments in our bodies, creating selective barriers, and protecting us from external pathogens. In epithelial tissues, cells experience a range of ...
Mechanisms and Consequences of GLO1 Attenuation in Obese Skeletal Muscle: Exploring a Potential Role for SIRT1-Mediated GLO1 Stability
(2022)
The obesity pandemic is persistent with global rates of obesity exceeding 13%. Obesity results in the development of insulin resistance which through a myriad of mechanisms increases the risk for secondary disease development ...
Dynamics of Influenza Protection and Infection: Implications for Vaccination Development
(2022)
Influenza is a major contributor to respiratory morbidity and mortality worldwide and is a particular concern for high-risk populations including children. Although influenza has been studied for over 100 years, major gaps ...
The Regulatory Mechanisms of PIR-B and STARD7 in Inflammatory Bowel Disease
(2022)
Rationale: The inflammatory bowel diseases (IBD), Crohn’s Disease (CD) and Ulcerative Colitis (UC) are chronic relapsing gastrointestinal (GI) inflammatory diseases that are driven by a breakdown of the intestinal epithelial ...
Prevention Strategies for Gynecologic Cancers
(2022)
This dissertation focused on prevention strategies for ovarian and cervical cancers. Primary prevention of ovarian cancer was explored in Aim 1 using data from the Ovarian Cancer Association Consortium (OCAC; 7,743 cases; ...
Engineering Multifunctional Nanoparticles: Applied Nanoscale Therapeutics
(2022)
Decades of research towards the development of nanomedicines have, to date, yielded minimal
clinical impact. Focused particularly on the treatment of cancer, the relatively low
number of pursued technologies to reach the ...
Pre-Clinical Investigation of Histotripsy for Non-Invasive Ablation of Liver Cancer
(2022)
Liver cancer, including hepatocellular carcinoma (HCC) is one of the top ten causes of cancer related deaths worldwide and in the United States. The liver is also a frequent site for metastases originating from colorectal ...