Now showing items 4731-4740 of 4800
Solid State NMR Investigations of Lipid Bilayers and Biomembrane Binding Molecules: Dendrimers and Amylin.
(2010)
The goal of this project was to investigate the interaction between lipid binding molecules, such as peptides and drug compounds, with biological lipid bilayers. The results demonstrate that human amylin, a peptide hormone ...
The Regulation of Drosophila Inhibitor of Apoptosis Protein I in Apoptosis and Cell Survival.
(2009)
Apoptosis is an evolutionarily conserved, actively regulated cell death process that plays an essential role during development and in adulthood. It is subject to negative regulation by Inhibitor of Apoptosis Proteins ...
Identification of Relevant Protein-Gene Associations by Integrating Gene Expression Data and Transcriptional Regulatory Networks.
(2010)
One challenge in systems biology is integrating different biological data types to more accurately describe how a biological system functions. If networks describing a pathway or a particular regulatory activity is merged ...
Elucidating the Functions of Protein Disulfide Isomerase Family Proteins during Quality Control in the Endoplasmic Reticulum.
(2009)
The endoplasmic reticulum (ER) quality control system retains nascent polypeptides in the organelle until they are folded properly and mediates the ER-to-cytosol transport (i.e., retrotranslocation) of misfolded proteins ...
Activity-Dependent Regulation of Ether á … go-go K+ Channels.
(2008)
The Drosophila ether á go-go (eag) gene encodes a partially inactivating, voltage-gated K+ channel expressed at neuromuscular and CNS synapses. Recordings from the larval neuromuscular junctions (NMJs) of eag mutants, ...
Analysis of the Molecular Mechanism of Autophagosome Formation in Saccharomyces Cerevisiae.
(2009)
Autophagy is an evolutionarily conserved catabolic pathway, which is involved in the degradation of long-lived proteins, organelles, and a large portion of the cytoplasm in response to internal and external stresses, such ...
The Role of Gata2 in Hematopoietic and Vascular Development.
(2009)
Transcription factors play demonstrably critical roles in development. The transcription factor Gata2 is required for the proliferation of hematopoietic progenitors and proper urogenital development. Gata2 null mutant mice ...
Proteoglycan-4: A Dynamic Regulator of Parathyroid Hormone Biologic Actions.
(2011)
Intermittent parathyroid hormone (PTH) (1-34) is the only anabolic agent currently approved for the treatment of osteoporosis in the U.S. PTH (1-34) is under clinical investigations as a local bone regenerative therapy ...
Control of Glucose Homeostatis through Ubiquitin-Specific Protease 2.
(2011)
Hepatic gluconeogenesis is important for maintaining steady blood glucose levels during starvation and through light/dark cycles. The regulatory network that transduces hormonal and circadian signals serves to integrate ...
Regulation of Bone Formation and Pathology by Local Actions of Leptin in the Bone Marrow.
(2011)
Site-specific adipose content of the bone marrow has been noted since the inclusion
of meat into the hominid diet, evidenced by marrow removal from ungulate limb
bones, 2.6 million years ago. Association between marrow fat ...