Now showing items 4751-4760 of 4795
Characterization of Mouse Models to Study Protein Trafficking in the Early Secretory Pathway.
(2011)
Newly synthesized proteins destined for secretion or trafficking to the lysosomes, secretory granules, or cell surface, exit the endoplasmic reticulum (ER) in coat protein complex-II (COPII) vesicles. The SEC24 subunit ...
Differential Regulation of Two- and Three-Dimensional Cell Function.
(2011)
The extracellular matrix (ECM) is a heterogeneous network of proteins, glycoproteins, and proteoglycans that not only scaffolds tissues but also acts as a central modulator of essential cell functions including proliferation, ...
GPCR-dependent NF-kB Signaling in Endothelial Dysfunction: A Critical Role for the CARMA3/BcI10/MALT1 Signaling Complex.
(2011)
Atherosclerosis is a complex inflammatory disease. Atherosclerotic lesions are characterized by the accumulation of lipid particles and immune cells in the subendothelial space, resulting in the narrowing of the arterial ...
Characterizing the role of ADAM10 and 15 disintegrins in prostate biology and disease
(2011)
During the progression of prostate cancer, the adhesion molecule epithelial (E)-cadherin can be lost from the cell surface by ADAM15 proteolytic processing, generating an extracellular 80kDa fragment referred to as soluble ...
Roles for Condensin in C. elegans Chromosome Dynamics.
(2011)
Condensin complexes are essential for higher order organization of chromosome
structure. Higher eukaryotes have two condensins (condensin I and II) dedicated to
mitotic and meiotic chromosome dynamics. C. elegans was thought ...
The Application of Genetic, In Silico and In Vitro Tools to Elucidate the Biology of a Functional Amyloid Fiber.
(2010)
Curli are thin aggregative fimbriae produced by many Enterobacteriaceae as a structural component of biofilms. Curli share many biochemical and biophysical properties with amyloid fibers which are often associated with ...
Directed Evolution Designed to Optimize the in vivo Protein Folding Environment.
(2010)
Protein folding is assisted by molecular chaperones and folding catalysts in vivo. Understanding how chaperones are regulated and how they function in vivo may provide new avenues for developing protein folding modulators. ...
Role of Protein Oligomerization in Regulation of Wnt Target Gene Transcription.
(2010)
Wnt/Wg signaling is a highly conserved signaling pathway that is important for animal development and adult homeostasis. There are so many aspects of the pathway that are not well understood, and transcriptional regulation ...
Roles of Lipid and Protein Receptors in Regulating Polyomavirus Infection.
(2010)
The non-enveloped murine polyomavirus (Py) binds to receptors on the cell surface to gain entry into host cells. The virus then traffics to the endoplasmic reticulum (ER) where it penetrates the membrane and enters the ...
The Role of Ribosome Biogenesis in Arabidopsis thaliana Root Development and Epidermal Patterning.
(2011)
The establishment of distinct patterns of gene expression is essential to the differentiation of specialized cell types during the development of multicellular organisms. To investigate the regulatory networks involved ...