Now showing items 671-678 of 678
Bayesian Network Approaches for Refining and Expanding Cellular and Immunological Pathways.
(2011)
This thesis focuses on computational analysis of cellular and immune pathways of living cells in response to molecular signals using Bayesian networks (BN). Although Bayesian networks have been applied to the reconstruction ...
Role of CHD7 in Neural Development and Maintenance.
(2011)
Normal tissue development and maintenance require precise timing and correct localization of gene expression. Several lines of evidence indicate that the chromodomain (CHD) family of proteins are critical regulators of ...
The Application of Genetic, In Silico and In Vitro Tools to Elucidate the Biology of a Functional Amyloid Fiber.
(2010)
Curli are thin aggregative fimbriae produced by many Enterobacteriaceae as a structural component of biofilms. Curli share many biochemical and biophysical properties with amyloid fibers which are often associated with ...
Directed Evolution Designed to Optimize the in vivo Protein Folding Environment.
(2010)
Protein folding is assisted by molecular chaperones and folding catalysts in vivo. Understanding how chaperones are regulated and how they function in vivo may provide new avenues for developing protein folding modulators. ...
Phototaxis and Phototransduction Mechanisms in the Model System C. elegans.
(2010)
C. elegans has become an increasingly popular model system for the study of sensory systems, in particular olfactory transduction and mechanotransduction. However, C. elegans is eyeless and lives in darkness (i.e. soil), ...
Regulating Gene Expression Through DNA Mechanics: Tightly Looped DNA Represses Transcription.
(2010)
It is now widely accepted that the mechanical state of DNA can play a major role in regulating the activity of RNA polymerase (RNAP). Not only have the global levels of supercoiling been shown to regulate transcription, ...
Intergenerational arsenic exposure on the mouse epigenome and metabolic physiology
(John Wiley & Sons, Inc., 2023-02)
Inorganic arsenic (iAs) is one of the largest toxic exposures to impact humanity worldwide. Exposure to iAs during pregnancy may disrupt the proper remodeling of the epigenome of F1 developing offspring and potentially ...
Neurofibromin 2 (NF2) Is Necessary for Efficient Silencing of LINE-1 Retrotransposition Events in Human Embryonic Carcinoma Cells
(2022)
Transposable elements are DNA sequences that can mobilize to new genomic locations and have had a profound impact on human genome evolution. Although ~45% of the human genome consists of transposable element-derived ...