Now showing items 1-10 of 17
Tumor Necrosis Factor-Regulated Granuloma Formation in Tuberculosis: Multi-Scale Modeling and Experiments.
(2012)
Tuberculosis is a deadly infectious disease caused by Mycobacterium tuberculosis (Mtb). Multiple immune factors control host responses to Mtb infection, including the formation of granulomas in the lung, which are aggregates ...
Structural Characterization and Impedance Spectroscopy of Substituted, Fused-Ring Organic Semiconductors.
(2011)
Organic materials present a number of advantages over silicon that make them ideal candidates for modest performance devices like active matrix backplanes and RFID tags. The work detailed here describes both structural ...
Mechanistic and Statistical Models to Understand CXCL12/CXCR4/CXCR7 in Breast Cancer.
(2015)
Signaling via the CXCL12/CXCR4 axis is instrumental to the metastasis of more than 20 cancers, yet blocking the pathway alone has not been effective as cancer therapy. Since cancer progression results from a complex network ...
Synthesis and Characterization of Microporous Coordination Polymers as Adsorbents for CO2 Capture.
(2012)
The accumulation of CO2 in the Earth’s atmosphere is an important environmental issue, and coal-fired power plants are significant contributors to anthropogenic CO2 emissions. The capture of CO2 from these facilities via ...
Folate Binding Protein as a Therapeutic Natural Nanotechnology
(2018)
Serum proteins interact with small molecules and nanoparticles in blood, resulting in protein coronas. Protein coronas influence the bioidentity of the molecules and nanoparticles, playing critical roles in biotransport, ...
Predicting the Formation Pathways and Morphologies of Oxygenated Carbonaceous Nanoparticle Precursors in Premixed Flames
(2017)
Organic nanoparticles are an inevitable by-product of combustion phenomena that have deleterious health and environmental effects. They are carcinogenic because they damage biological cells due to their small size and their ...
Biological Applications of Surfaces with Extreme Wettabilities
(2019)
Surfaces with extreme wettabilities have become an increasingly popular topic due to their wide range of applications – from simply keeping dirt off clothing to oil-water separation in the event of an oil spill. In particular, ...
In Vitro and In Vivo Testing of Ultra-Small Gold Nanoparticles as a Novel Drug Delivery Platform for Enhancing the Brain Penetration and Receptor Binding Affiinity of Central Nervous System Drugs.
(2013)
The endothelial cells of brain capillaries form the so-called blood brain barrier (BBB) which protects the central nervous system (CNS) from the entry of neurotoxins and blood components. Consequently, more than 98% of ...
Microfluidic Technologies for Bioanalytical Chemistry: Advancing Epigenetic Profiling via Chromatin Immunoprecipitation in Droplets
(2019)
Beyond the linear sequence of the genome, the epigenome dynamically controls chromatin remodeling and transcriptional poise without inducing changes in DNA sequence. These epigenetic mechanisms, particularly modifications ...
Understanding the Solution Phase Chemistry and Solid State Thermodynamic Behavior of Pharmaceutical Cocrystals.
(2012)
This dissertation focuses on the thermodynamic stability and solubility of pharmaceutical cocrystals. Specifically, the objectives are to; (i) investigate the influence of coformer properties such as solubility and ionization ...