Now showing items 1-10 of 17
Tumor Necrosis Factor-Regulated Granuloma Formation in Tuberculosis: Multi-Scale Modeling and Experiments.
(2012)
Tuberculosis is a deadly infectious disease caused by Mycobacterium tuberculosis (Mtb). Multiple immune factors control host responses to Mtb infection, including the formation of granulomas in the lung, which are aggregates ...
Hydrothermal catalytic production of fuels and chemicals from aquatic biomass
(John Wiley & Sons, Ltd, 2013-01)
One of the promising avenues for biomass processing is the use of water as a reaction medium for wet or aquatic biomass. This review focuses on the hydrothermal catalytic production of fuels and chemicals from aquatic ...
Isolation, Expansion and Characterization of Circulating Tumor Cells using Microfluidic Technologies.
(2016)
Circulating tumor cells (CTCs) are the tumor cells shed from primary tumor, which enter the bloodstream and travel to distant anatomic sites to form metastasis. Detecting CTCs, as a means of “liquid biopsy”, allows monitoring ...
Methodological Advances for Drug Discovery and Protein Engineering
(2018)
Designing and engineering molecules that have specified properties not only test our understanding of nature but also play an important role in improving both human health and industrial productivity. Two such examples are ...
Developing and Applying Microdroplet Co-Cultivation Technology for Elucidating Bacterial Interspecies Interactions in the Human Vaginal Microbiome
(2020)
The role of the human vaginal microbiome (HVM) has gained increased recognition
due to recent technological advancements that helped link community composition
and women's health risks. However, the ecological roles of ...
Biological Applications of Surfaces with Extreme Wettabilities
(2019)
Surfaces with extreme wettabilities have become an increasingly popular topic due to their wide range of applications – from simply keeping dirt off clothing to oil-water separation in the event of an oil spill. In particular, ...
In Vitro and In Vivo Testing of Ultra-Small Gold Nanoparticles as a Novel Drug Delivery Platform for Enhancing the Brain Penetration and Receptor Binding Affiinity of Central Nervous System Drugs.
(2013)
The endothelial cells of brain capillaries form the so-called blood brain barrier (BBB) which protects the central nervous system (CNS) from the entry of neurotoxins and blood components. Consequently, more than 98% of ...
Injectable Multi-Drug Formulation for the Postoperative Management of Ocular Surgery
(2017)
In this dissertation, the interaction between particles or particles and polymers were examined. In addition, outcomes of such studies were used to develop drug delivery formulations.
Initially, by carrying out Brownian ...
Mechanisms and Engineering of Polymeric Nanoparticles for Modulating Innate and Adaptive Immune Responses
(2019)
The delivery of disease-relevant antigens by nanoparticles is a promising strategy for selectively inhibiting pathogenic autoreactive cells while maintaining a protective immune repertoire. This process, known as ...
Microfluidic Technologies for Bioanalytical Chemistry: Advancing Epigenetic Profiling via Chromatin Immunoprecipitation in Droplets
(2019)
Beyond the linear sequence of the genome, the epigenome dynamically controls chromatin remodeling and transcriptional poise without inducing changes in DNA sequence. These epigenetic mechanisms, particularly modifications ...