Now showing items 1-10 of 10
Methodological Advances for Drug Discovery and Protein Engineering
(2018)
Designing and engineering molecules that have specified properties not only test our understanding of nature but also play an important role in improving both human health and industrial productivity. Two such examples are ...
Quantum Inspired Machine Learning Algorithms for Adaptive Radiotherapy
(2021)
Adaptive radiotherapy (ART) refers to the modification of radiotherapy treatment plans in response to patient anatomical and physiological changes over the course of treatment and has been recognized as an important step ...
Nanopores with Fluid Walls for Characterizing Proteins and Peptides.
(2012)
Nanopore-based, resistive-pulse sensing is a simple single-molecule technique, is label free, and employs basic electronic recording equipment. This technique shows promise for rapid, multi-parameter characterization of ...
Acoustically-Responsive Scaffolds: Control of Growth Factor Release for Tissue Regeneration Using Ultrasound
(2017)
Administration of exogenous growth factors (GFs) is a proposed method of stimulating tissue regeneration. Conventional administration routes, such as at-site or systemic injections, have yielded problems with efficacy ...
The Effects of Disruption of Synaptic Signaling on Neuronal Networks
(2020)
The brain is an organ that acts as the conductor of an orchestra – it governs all vital body functions and assures that all organs operate in harmony. Moreover, it plays a crucial role in various tasks such as memory ...
Multidisciplinary Study of Soft Shape Morphing Systems
(2021)
Nature abounds with examples of shape morphing systems where an entity either gradually grows into a complex 3-D shape pattern or rapidly morphs into a new configuration. Inspired by the shape shifting capabilities of ...
Advances in Quantitative MRI: Acquisition, Estimation, and Application
(2018)
Quantitative magnetic resonance imaging (QMRI) produces images of potential MR biomarkers: measurable tissue properties related to physiological processes that characterize the onset and progression of specific disorders. ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
Ultrasound-triggered Drug Delivery Using Acoustic Droplet Vaporization.
(2010)
The goal of targeted drug delivery is the spatial and temporal localization of a therapeutic agent and its associated bioeffects. One method of drug localization is acoustic droplet vaporization (ADV), whereby drug-laden ...
Regulating Gene Expression Through DNA Mechanics: Tightly Looped DNA Represses Transcription.
(2010)
It is now widely accepted that the mechanical state of DNA can play a major role in regulating the activity of RNA polymerase (RNAP). Not only have the global levels of supercoiling been shown to regulate transcription, ...