Now showing items 1-10 of 47
An Antibiotic Discovery Campaign Targeting VirF, the Main Transcriptional Regulator of Virulence in Shigella flexneri
(2016)
Shigella flexneri is a gram-negative enteropathogen that infects the human colonic epithelium. It is estimated that Shigella spp. infect 165 million people a year worldwide. Symptoms of shigellosis include bloody dysentery, ...
Designing Thermal Modulators for Portable GC x GC Systems.
(2015)
Microelectromechanical systems (MEMS) have the advantage of scale and can be manufactured in bulk. One of the active areas of MEMS research is the development of micro-scale comprehensive two-dimensional gas chromatography ...
Design Challenges in Nanoparticle-based Platforms: Implications for Targeted Drug Delivery Systems.
(2010)
Characterization and control of heterogeneous distributions of nanoparticle-ligand components are major design challenges for nanoparticle-based platforms. This dissertation begins with an examination of poly(amidoamine) ...
Disruption of Endosomal Membrane by Cationic Vectors Drives Endosomal Release and Enables Successful Gene Delivery
(2016)
The potential of gene therapy to treat congenital disorders is hindered by the lack of safe and effective delivery agents (vectors). More effective viral vectors possess several safety concerns but the safer non-viral ...
Design, Synthesis and Biological Evaluation of Non-Peptidic Small Molecular SMAC Mimetics as Potent IAP Inhibitors.
(2008)
The resistance of tumor cells to apoptosis is a major problem in current cancer therapies. Successful anticancer strategies would benefit from specific targeting of the pathways that cause the resistance. Hence, targeting ...
Targeting the BCL9/B9L Binding Interaction with B-catenin as a Potential Anticancer Strategy.
(2010)
Wnt signaling plays a critical role in numerous cellular processes including embryonic development, cell proliferation and tissue homeostasis. The multifunctional protein β-catenin is the primary mediator of canonical Wnt ...
Protein Flexibility in Structure-Based Drug Design: Method Development and Novel Mechanisms for Inhibiting HIV-1 Protease.
(2007)
Structure-based drug design (SBDD) has emerged as an important tool in drug discovery research. Traditionally, SBDD is based on a static crystal structure of the target protein. However, a protein in solution exists as an ...
Methodological Advances for Drug Discovery and Protein Engineering
(2018)
Designing and engineering molecules that have specified properties not only test our understanding of nature but also play an important role in improving both human health and industrial productivity. Two such examples are ...
Inhibiting the Actions of Essential Biomolecule Phosphopantetheine.
(2015)
Phosphopantetheine is an essential biomolecule required for life. The enzyme phosphopantothenoylcysteine synthetase (PPCS) incorporates the reactive thiol moiety in the Coenzyme A (CoA) biosynthetic pathway. Two types of ...
Novel Modulators of Rho Transcriptional Signaling in Cancer.
(2012)
Rho A and Rho C, members of the Rho GTPase family, have been found to have important roles in the metastases of multiple cancers, including melanoma, prostate, and breast cancer. While Rho GTPases are known to have effects ...