Permeation of water contaminative phenols through hairless mouse skin
dc.contributor.author | Ho, Norman F. H. | en_US |
dc.contributor.author | Condie, L. | en_US |
dc.contributor.author | Jetzer, W. E. | en_US |
dc.contributor.author | Flynn, Gordon L. | en_US |
dc.contributor.author | Husari, N. | en_US |
dc.contributor.author | Huq, A. S. | en_US |
dc.date.accessioned | 2006-09-11T19:43:27Z | |
dc.date.available | 2006-09-11T19:43:27Z | |
dc.date.issued | 1986-09 | en_US |
dc.identifier.citation | Huq, A. S.; Ho, N. F. H.; Husari, N.; Flynn, G. L.; Jetzer, W. E.; Condie, L.; (1986). "Permeation of water contaminative phenols through hairless mouse skin." Archives of Environmental Contamination and Toxicology 15(5): 557-566. <http://hdl.handle.net/2027.42/48064> | en_US |
dc.identifier.issn | 0090-4341 | en_US |
dc.identifier.issn | 1432-0703 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/48064 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3753043&dopt=citation | en_US |
dc.description.abstract | As a means of determining the risk of absorption of water contaminative phenolic compounds through the skin, the permeation of a number of phenols, all on the U.S. Environmental Protection Agency's list of priority pollutants, through hairless mouse skin has been studied, using in vitro diffusion cell methods. Experimentally determined permeability coefficients through intact skin and stratum corneum denuded skin and permeability coefficients derived therefrom for the viable tissue layer and the stratum corneum, which are the tissue's major contributing substrata, have been correlated with their log K octanol/water partition coefficients. Permeability coefficients for the whole skin and the stratum corneum systematically increased with increasing phenol lipophilicity to limiting values of about 0.15 and 0.30 cm/hr, respectively. The values of the permeability coefficients for the viable tissue were roughly the same for all compounds (≈0.36 cm/hr). Because of the inductive effects of Cl and NO 2 substituents on the aromatic ring, phenolic analogs containing these moieties are acidic and, consequently, their overall skin permeabilities were highly pH-dependent in the range of pH values seen for surface waters. High fluxes were noted for such phenols at low pH, where they exist essentially in a non-ionized state. Though low, fluxes of the compounds were measurable at pH's ≫ pK a 's, indicating that phenolic anions also pass through the skin. With the exceptions of relatively polar phenol and the mono-nitro phenols, the free acid forms of all the phenols studied permeated skin with ease and at rates approaching those of denuded skin. The intact skin permeability coefficient of the free acid form of 4-nitro phenol was exceptionally low, which suggests that it might associate intermolecularly. | en_US |
dc.format.extent | 939155 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag New York Inc. | en_US |
dc.subject.other | Waste Management/Waste Technology | en_US |
dc.subject.other | Terrestrial Pollution | en_US |
dc.subject.other | Environment, General | en_US |
dc.subject.other | Agriculture | en_US |
dc.subject.other | Environment | en_US |
dc.subject.other | Forestry | en_US |
dc.subject.other | Ecology | en_US |
dc.subject.other | Soil Science & Conservation | en_US |
dc.subject.other | Waste Water Technology / Water Pollution Control / Water Management / Aquatic Pollution | en_US |
dc.title | Permeation of water contaminative phenols through hairless mouse skin | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, 48109-1065, Ann Arbor, Michigan; United States Environmental Protection Agency, 26 West St. Clair St., 05268, Cincinnati, Ohio | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, 48109-1065, Ann Arbor, Michigan; United States Environmental Protection Agency, 26 West St. Clair St., 05268, Cincinnati, Ohio; Pharmacy Research Unit, The Upjohn Co., 49001, Kalamazoo, MI | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, 48109-1065, Ann Arbor, Michigan; United States Environmental Protection Agency, 26 West St. Clair St., 05268, Cincinnati, Ohio | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, 48109-1065, Ann Arbor, Michigan; United States Environmental Protection Agency, 26 West St. Clair St., 05268, Cincinnati, Ohio; Kantonsspital Bruderholz Pharmaceutical Department, CH-4101, Bruderholz, BL, Switzerland | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, 48109-1065, Ann Arbor, Michigan; United States Environmental Protection Agency, 26 West St. Clair St., 05268, Cincinnati, Ohio; Squibb Institute for Medical Research, P. O. Box 191, 08903, New Brunswick, NJ | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, 48109-1065, Ann Arbor, Michigan; United States Environmental Protection Agency, 26 West St. Clair St., 05268, Cincinnati, Ohio | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 3753043 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/48064/1/244_2005_Article_BF01056570.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01056570 | en_US |
dc.identifier.source | Archives of Environmental Contamination and Toxicology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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