Regulating leukotriene synthesis: The role of nuclear 5-lipoxygenase
Brock, Thomas G.
Brock, Thomas G. (2005)."Regulating leukotriene synthesis: The role of nuclear 5-lipoxygenase." Journal of Cellular Biochemistry 96(6): 1203-1211. <http://hdl.handle.net/2027.42/49282>
AbstractLeukotrienes are lipid messengers involved in autocrine and paracrine cellular signaling. They are synthesized from arachidonic acid by the 5-lipoxygenase pathway. Current models of this enzymatic pathway recognize that a key step in initiating leukotriene synthesis is the calcium-mediated movement of enzymes, including 5-lipoxygenase, to intracellular membranes. However, 5-lipoxygenase can be imported into or exported from the nucleus before calcium activation. As a result, its subcellular localization will affect its ability to be activated by calcium, as well as the membrane to which it binds and its interaction with other enzymes. This commentary focuses on the role of 5-lipoxygenase compartmentation in determining its regulation and, ultimately, leukotriene synthesis. J. Cell. Biochem. © 2005 Wiley-Liss, Inc.
Wiley Subscription Services, Inc., A Wiley Company
MetadataShow full item record
Accessibility: If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.