Regulating leukotriene synthesis: The role of nuclear 5-lipoxygenase
dc.contributor.author | Brock, Thomas G. | en_US |
dc.date.accessioned | 2007-01-17T15:53:07Z | |
dc.date.available | 2007-01-17T15:53:07Z | |
dc.date.issued | 2005-12-15 | en_US |
dc.identifier.citation | Brock, Thomas G. (2005)."Regulating leukotriene synthesis: The role of nuclear 5-lipoxygenase." Journal of Cellular Biochemistry 96(6): 1203-1211. <http://hdl.handle.net/2027.42/49282> | en_US |
dc.identifier.issn | 0730-2312 | en_US |
dc.identifier.issn | 1097-4644 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/49282 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16215982&dopt=citation | en_US |
dc.description.abstract | Leukotrienes are lipid messengers involved in autocrine and paracrine cellular signaling. They are synthesized from arachidonic acid by the 5-lipoxygenase pathway. Current models of this enzymatic pathway recognize that a key step in initiating leukotriene synthesis is the calcium-mediated movement of enzymes, including 5-lipoxygenase, to intracellular membranes. However, 5-lipoxygenase can be imported into or exported from the nucleus before calcium activation. As a result, its subcellular localization will affect its ability to be activated by calcium, as well as the membrane to which it binds and its interaction with other enzymes. This commentary focuses on the role of 5-lipoxygenase compartmentation in determining its regulation and, ultimately, leukotriene synthesis. J. Cell. Biochem. © 2005 Wiley-Liss, Inc. | en_US |
dc.format.extent | 181546 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Regulating leukotriene synthesis: The role of nuclear 5-lipoxygenase | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan ; 6301 MSRB III, 1150 W Medical Center Drive, University of Michigan, Ann Arbor, MI 48109. | en_US |
dc.identifier.pmid | 16215982 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/49282/1/20662_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jcb.20662 | en_US |
dc.identifier.source | Journal of Cellular Biochemistry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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