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Regulating leukotriene synthesis: The role of nuclear 5-lipoxygenase

dc.contributor.authorBrock, Thomas G.en_US
dc.date.accessioned2007-01-17T15:53:07Z
dc.date.available2007-01-17T15:53:07Z
dc.date.issued2005-12-15en_US
dc.identifier.citationBrock, Thomas G. (2005)."Regulating leukotriene synthesis: The role of nuclear 5-lipoxygenase." Journal of Cellular Biochemistry 96(6): 1203-1211. <http://hdl.handle.net/2027.42/49282>en_US
dc.identifier.issn0730-2312en_US
dc.identifier.issn1097-4644en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/49282
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16215982&dopt=citationen_US
dc.description.abstractLeukotrienes are lipid messengers involved in autocrine and paracrine cellular signaling. They are synthesized from arachidonic acid by the 5-lipoxygenase pathway. Current models of this enzymatic pathway recognize that a key step in initiating leukotriene synthesis is the calcium-mediated movement of enzymes, including 5-lipoxygenase, to intracellular membranes. However, 5-lipoxygenase can be imported into or exported from the nucleus before calcium activation. As a result, its subcellular localization will affect its ability to be activated by calcium, as well as the membrane to which it binds and its interaction with other enzymes. This commentary focuses on the role of 5-lipoxygenase compartmentation in determining its regulation and, ultimately, leukotriene synthesis. J. Cell. Biochem. © 2005 Wiley-Liss, Inc.en_US
dc.format.extent181546 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleRegulating leukotriene synthesis: The role of nuclear 5-lipoxygenaseen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan ; 6301 MSRB III, 1150 W Medical Center Drive, University of Michigan, Ann Arbor, MI 48109.en_US
dc.identifier.pmid16215982en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/49282/1/20662_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/jcb.20662en_US
dc.identifier.sourceJournal of Cellular Biochemistryen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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