Now showing items 31-40 of 52
A 13 base pair deletion in exon 1 of HPRT Illinois forms a functional GUG initiation codon
(Springer-Verlag, 1994-03)
More than 50 mutations in the human hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus have been described, yet only 2 alter the AUG initiation codon. One, variant HPRT 1151 , results in Lesch-Nyhan syndrome (LNS), ...
Immunochemical methods of studying the mechanism of diclofenac-induced hepatitis
(John Wiley & Sons, Inc., 1994-10)
No Abstract.
Use of receptors immobilized on microspheres to identify ligand binding sites in tissue sections: detection of lymph node ligands for L-Selectin
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1997-01)
Particulate microspheres bearing immobilized probes can be used to identify ligands expressed by cells and require only brightfield microscopy for detection. There are distinct advantages to using microspheres to detect ...
Defective CD2 pathway T cell activation in systemic lupus erythematosus
(John Wiley & Sons, Inc., 1991-05)
CD2 (T11; sheep erythrocyte receptor) is the surface component of an alternative, antigen-independent pathway of human T cell activation. The response to certain anti-CD2 antibodies is relatively independent of accessory ...
Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis
(John Wiley & Sons, Inc., 1990-11)
Procainamide and hydralazine inhibit T cell DNA methylation and induce autoreactivity in cloned CD4+ T cells. These drugs also induce an autoimmune syndrome, suggesting a possible relationship between DNA hypomethylation, ...
Expression of interleukin-1 and interleukin-1 receptor antagonist by human rheumatoid synovial tissue macrophages
(Elsevier, 1992-10)
Interleukin-1 (IL-1) has protean effects in the pathogenesis of rheumatoid arthritis (RA). These effects include production of prostaglandins and collagenase from rheumatoid fibroblasts as well as upregulation of adhesion ...
Structures on the cell surface. Update from the fifth international workshop on human leukocyte differentiation antigens
(John Wiley & Sons, Inc., 1994-12)
No Abstract.
Mechanisms of drug-induced lupus. III. Sex-specific differences in T cell homing may explain increased disease severity in female mice
(John Wiley & Sons, Inc., 1997-07)
Objective . To determine if sex-specific differences in lymphocyte trafficking could contribute to increased disease severity in female mice. Methods . A lupus-like disease was induced by injecting male and female mice ...
Mechanisms of drug-induced lupus. IV. Comparison of procainamide and hydralazine with analogs in vitro and in vivo
(John Wiley & Sons, Inc., 1997-08)
Objective . T cells treated with DNA methylation inhibitors overexpress lymphocyte function-associated antigen 1 (LFA-1), which results in autoreactivity, and the autoreactive cells cause a lupus-like disease in vivo, ...
Effect of slow release IL-12 and IL-10 on inflammation, local macrophage function and the regional lymphoid response during mycobacterial (Th1) and schistosomal (Th2) antigen-elicited pulmonary granuloma formation
(Birkhäuser Verlag; Birkhäuser Verlag, Basel, ; Springer Science+Business Media, 1997-03)
Objective and Design: This study examines the local and regional effects of exogenously administered interleukins 10 (IL-10) and 12 (IL-12) on pulmonary granulomas mediated by Th1/type 1-(IFN-<gamma>) and Th2/type 2-(IL-4, ...