Now showing items 61-70 of 94
A comparison of D1 receptor binding and mRNA in rat brain using receptor autoradiographic and in situ hybridization techniques
(Elsevier, 1991)
D1, a subtype of the dopamine receptors, is widely distributed in the nervous system and has been shown to be positively coupled to adenylate cyclase. Using a combination of in vitro receptor autoradiographic and in situ ...
Hormonal effects on extra- and intraneural mechanism: an integrative approach
(Elsevier, 1993-12-01)
Multiple HPA profiles in endogenous depression: Effect of age and sex on cortisol and beta-endorphin
(Elsevier, 1993-01-15)
We have previously shown that a number of depressed patients demonstrated a failure to suppress corticotrophic secretion, as measured by [beta]-Endorphin/[beta]-Lipotropin ([beta]-End/[beta]-LPH levels), following dexamethasone ...
Nociceptin/orphanin FQ and opioid receptor-like receptor mRNA expression in dopamine systems
(Wiley Subscription Services, Inc., A Wiley Company, 2002-03-19)
Although nociceptin/orphanin FQ (N/OFQ) influences dopamine (DA) neuronal activity, it is not known whether N/OFQ acts directly on DA neurons, indirectly by means of local circuitry, or both. We used two parallel approaches, ...
Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: Comparison of ORL1 receptor mRNA expression with 125 I-[ 14 Tyr]-orphanin FQ binding
(John Wiley & Sons, Inc., 1999-10-04)
The recently discovered neuropeptide orphanin FQ (OFQ), and its opioid receptor-like (ORL1) receptor, exhibit structural features suggestive of the μ, κ, and δ opioid systems. The anatomic distribution of OFQ immunoreactivity ...
A possible interface between autonomic function and pain control: opioid analgesia and the nucleus tractus solitarius
(Elsevier, 1987-10-20)
Opioid peptides appear to be important neurochemical mediators in central nervous system mechanisms of analgesia, cardiovascular control, and many endocrinological responses to stress. The nucleus tractus solitarius (NTS), ...
Characterization of pro-opiomelanocortin processing in heterologous neuronal cells that express PC2 mRNA
(Elsevier, 1993-05)
We have investigated processing of monkey pro-opiomelanocortin (POMC) following transfection into heterologous neuronal Neuro 2A (N2A) cells. In several separately transfected stable cell lines (termed N2A/POMC2-like; N = ...
Selective Breeding for Divergence in Novelty-seeking Traits: Heritability and Enrichment in Spontaneous Anxiety-related Behaviors
(Kluwer Academic Publishers-Plenum Publishers; Springer Science+Business Media, Inc., 2006-02-24)
Outbred Sprague–Dawley rats can be classified as high responders (HR) or low responders (LR) based on their levels of exploratory locomotion in a novel environment. While this novelty-seeking dimension was originally related ...
Postdexamethasone plasma cortisol and [beta]-endorphin levels in depression: Relationship to severity of illness
(Elsevier, 1987-09)
The hypothalamic-pituitary-adrenal (HPA) axis is dysregulated in many patients with depression, probably at all levels of the axis. To determine if HPA dysregulation is associated with severity of depression, we studied a ...