Now showing items 51-60 of 94
[kappa]1 Receptor mRNA Distribution in the Rat CNS: Comparison to [kappa] Receptor Binding and Prodynorphin mRNA
(Elsevier, 1994-04)
Three opioid receptor types have been identified in the CNS and periphery that are referred to as [mu], [delta], and [kappa]. The present study examines the mRNA distribution of the [kappa]1 receptor in the rat brain and ...
Cloning and pharmacological characterization of a rat [mu] opioid receptor
(Elsevier, 1993-11)
We have isolated a rat cDNA clone that displays 75% amino acid homology with the mouse [delta] and rat [kappa] opioid receptors. The cDNA (designated pRMuR-12) encodes a protein of 398 amino acids comprising, in part, seven ...
Processing of prodynorphin by the prohormone convertase PC1 results in high molecular weight intermediate forms : Cleavage at a single arginine residue
(Elsevier, 1994-01-03)
Processing of rat prodynorphin (proDyn) by the mouse prohormone convertase PCI was investigated. Recombinant vaccinia virus vectors were used to coexpress proDyn and PC1 in rat PC12 pheochromocytoma and mouse AtT-20 ...
Dynorphin (1-17): Lack of analgesia but evidence for non-opiate electrophysiological and motor effects
(Elsevier, 2006-04-07)
Dynorphin and an opiate-inactive fragment des-Tyr-dynorphin produced similar effects on EEG, motor function and hippocampal unit firing. Naloxone had no effect on the actions of dynorphin in these systems and dynorphin ...
Lateral hypothalamic innervation of the cerebral cortex: Immunoreactive staining for a peptide resembling but immunochemically distinct from pituitary/arcuate [alpha]-melanocyte stimulating hormone
(Elsevier, 1986-01)
The combination of retrograde transport of fluorescent dyes and indirect immunofluorescence has been used to study the putative neurotransmitter specificity of the tuberal lateral hypothalamic projection to the cerebral ...
Anatomical and biochemical studies of the opioid peptides and related substances in the brain
(Elsevier, 1980)
It is now clear that there are at least four opioid peptide-neuronal systems in mammalian brain: the enkephalins, beta-endorphin and dynorphin. The focus of this presentation will be twofold--to focus on the multiple ...
Cloning and expression of the A 2a adenosine receptor from guinea pig brain
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1994-05)
A full-length complementary DNA (cDNA) clone encoding the guinea pig brain A 2 adenosine receptor has been isolated by polymerase chain reaction (PCR) and low-stringency-hybridization screening of a guinea pig brain cDNA ...
Diurnal rhythmic expression of the rhythm-related genes, rPeriod1, rPeriod2, and rClock , in the rat brain
(Kluwer Academic Publishers; National Science Council, Taipei ; Springer Science+Business Media, 2005-01)
High densities of the mRNA of three rhythm-related genes, rPeriod1 (rPer1), rPer2 , and rClock , which share high homology in Drosophila and mammals, are found in the rat hypothalamic suprachiasmatic nucleus (SCN). The ...
Changes in releasability of ACTH and Beta-endorphin with chronic stress
(Elsevier, 1985-02)
The activation of the hypothalamic pituitary adrenal axis by stress is well-known. Using inescapable intermittent footshock as a stressor in rats, we have previously demonstrated a rise in circulating plasma Beta-endorph ...