Now showing items 1-10 of 71
Linearized embedding: A new metric matrix algorithm for calculating molecular conformations subject to geometric constraints
(John Wiley & Sons, Inc., 1989-10)
There are many methods in the literature for calculating conformations of a molecule subject to geometric constraints, such as those derived from two-dimensional NMR experiments. One of the most general ones is the EMBED ...
Carrier mediated transport of amino acids, small peptides, and their drug analogs
(Elsevier, 1987-12)
The oral absorption of amino acids, small peptides and their analogs has been studied in rats using single pass intestinal perfusion. The experimental data was analyzed using a modified boundary layer method permitting the ...
Cluster distance geometry of polypeptide chains
(Wiley Subscription Services, Inc., A Wiley Company, 2004-07-30)
Distance geometry has been a broadly useful tool for dealing with conformational calculations. Customarily each atom is represented as a point, constraints on the distances between some atoms are obtained from experimental ...
Benzimidazole ribonucleosides: Observation of an unexpected nitration when performing non-aqueous diazotizations with t-butyl nitrite
(Elsevier, 1992-09)
Mild, non-acidic conditions used in the non-aqueous diazotization of a 2-aminobenzimidazole nucleoside with t-butyl nitrite gave an unexpected 4-nitrobenzimidazol-2-one nucleoside which was not formed when primary alkyl ...
Electroencephalographic assessment of the role of [delta] receptors in opioid peptide - induced seizures
(Elsevier, 1984-12)
DPDPE ([D-Pen2, D-Pen5]-Enkephalin) and DPLPE ([D-Pen2, L-Pen5]-Enkephalin) are conformationally-constrained cyclic analogs of enkephalin with high selectivity for [delta] opioid receptors. Intracerebroventricular (i.c.v.) ...
Sensitive high-performance liquid chromatographic assay using 9-fluorenylmethylchloroformate for monitoring controlled-release lidocaine in plasma
(Elsevier, 1989)
A sensitive high-performance liquid chromatographic (HPLC) assay using fluorescence detection for quantifying lidocaine levels in plasma (in the ng/ml range) was developed. This novel HPLC assay has made possible the ...
A 1.8 Å resolution potential function for protein folding
(Wiley Subscription Services, Inc., A Wiley Company, 1990-08-15)
A general method is presented for constructing a potential function for approximate conformational calculations on globular proteins. The method involves solving a nonlinear program that seeks to adjust the potential's ...
Anticonvulsant effects of mu (DAGO) and delta (DPDPE) enkephalins in rats
(Elsevier, 1988)
The effects of highly selective mu and delta opioid peptide agonists were determined in two rat models of experimentally-induced convulsions, the flurothyl threshold test and the maximal electroshock test. Intracerebroventricular ...
A convenient synthesis of substituted [gamma]-pyrones
(Elsevier, 1980)
An efficient and general synthetic method for various 2-mono- and 2,6-disubstituted [gamma]-pyrones has been developed. This utilizes the -acylation (70-85%) of [beta]-methoxy-[alpha],[beta]-enone lithium enolates by acid ...