Now showing items 11-20 of 1414
Determination of water-soluble acid distribution in poly(lactide- co -glycolide)
(Wiley Subscription Services, Inc., A Wiley Company, 2004-02)
Determination of the kinetics of water-soluble degradation products inside poly(lactide- co -glycolide) (PLGA) delivery systems during polymer degradation is important to evaluate the polymer microclimate conditions, ...
Poly(glutamic acid) poly(ethylene glycol) hydrogels prepared by photoinduced polymerization: Synthesis, characterization, and preliminary release studies of protein drugs
(Wiley Subscription Services, Inc., A Wiley Company, 2002-10)
A class of new biodegradable hydrogels based on poly(ethylene glycol) methacrylate-graft-poly(glutamic acid) and poly(ethylene glycol) dimethacrylate was synthesized by photoinduced polymerization. Because all the polymeric ...
Medication errors and patient complications with continuous renal replacement therapy
(Springer-Verlag; IPNA, 2006-04-19)
Continuous renal replacement therapy (CRRT) is commonly used for renal support in the intensive care unit. While the risk of medication errors in the intensive care unit has been described, errors related specifically to ...
Physicochemical Characterization and Solubility Analysis of Thalidomide and Its N-Alkyl Analogs
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2002-01)
Purpose . The present study was primarily aimed at exploring the feasibility of improving percutaneous delivery via chemical manipulation of the thalidomide molecule to form analogs with improved physicochemical properties. ...
Statistical mechanics of protein folding with separable energy functions
(Wiley Subscription Services, Inc., A Wiley Company, 2004-06-15)
We have initiated an entirely new approach to statistical mechanical models of strongly interacting systems where the configurational parameters and the potential energy function are both constructed so that the canonical ...
Antitumor efficacy of tumor-antigen-encoding recombinant poxvirus immunization in Dunning rat prostate cancer: implications for clinical genetic vaccine development
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 2000-04)
One potential use for prostate-cancer-associated genes discovered through ongoing genetics studies entails the construction of virus- or plasmid-based recombinant vector vaccines encoding these new tumor-associated antigens ...
Percutaneous Delivery of Thalidomide and Its N-Alkyl Analogs
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2002-04)
Purpose . The purpose of this study was to determine the permeation parameters of thalidomide and three of its N -alkyl analogs and to establish a correlation between the physicochemical properties of these compounds and ...
Injectable microparticle–gel system for prolonged and localized lidocaine release. II. in vivo anesthetic effects
(Wiley Subscription Services, Inc., A Wiley Company, 2004-09-01)
Current treatment protocols for postoperative pain are beset by either the short duration of the anesthetic effect or requirement of hospitalization of the patients. We reported herein a novel treatment by applying to the ...
Low molecular weight protamine as an efficient and nontoxic gene carrier: in vitro study
(John Wiley & Sons, Ltd., 2003-08)
Background The structural similarity between low molecular weight protamine (LMWP), prepared by enzymatic digestion of protamine, and HIV-TAT protein transduction peptide suggested the feasibility of LMWP as an efficient ...
Development of polyphosphate parameters for use with the AMBER force field
(Wiley Subscription Services, Inc., A Wiley Company, 2003-07-15)
Accurate force fields are essential for reproducing the conformational and dynamic behavior of condensed-phase systems. The popular AMBER force field has parameters for monophosphates, but they do not extend well to ...