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- Creator:
- University of Michigan Museum of Paleontology and CTEES
- Description:
- Reconstructed CT slices for tooth in bone fragment of Colognathus obscurus (University of Michigan Museum of Paleontology catalog number UMMP 7506) as a series of TIFF images. Raw projections are not included in this dataset. The reconstructed slice data from the scan are offered here as a series of unsigned 16-bit integer TIFF images. The upper left corner of the first image (*_0000.tif) is the XYZ origin.
- Keyword:
- Paleontology, Fossil, CT, Reptile, UMMP, University of Michigan Museum of Paleontology, Triassic, and bf7ead64-3fff-a3f2-6b15-d04548dae2da
- Discipline:
- Science
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- Creator:
- Al Shidi, Qusai. and Pulkkinen, Tuija.
- Description:
- This is part of the simulation set of geomagnetic storms from 2010 to 2019. The Space Weather Modeling Framework (SWMF) with the configuration of SWPC v2 was used. The output files can be read by the visualization scripts included in the SWMF or the SpacePy Python package.
- Keyword:
- space weather, space physics, geomagnetic storms, and magnetosphere
- Discipline:
- Science
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- Creator:
- Lumeng, Julie C
- Description:
- Healthy full-term infants were enrolled in a longitudinal study designed to examine the development of infant eating behavior. Infant weight and length was measured, mothers completed questionnaires regarding infant eating behaviors, and infants were weighed and length measured at ages 1, 2, 4, 6 and 10 months. Trajectories of eating behaviors were identified using latent class growth modeling and bivariate analyses examined associations of infant eating behavior trajectory membership with infant and maternal characteristics. Cross-lagged analyses examined associations between BEBQ subscales and infant weight-for-length z-score.
- Keyword:
- infant, eating, weight gain, and feeding
- Citation to related publication:
- Harlan McCaffery, Julie Zaituna, Sophie Busch, Niko Kaciroti, Alison L. Miller, Julie C. Lumeng, Katherine L. Rosenblum, Ashley Gearhardt, Megan H. Pesch, Developmental trajectories of eating behaviors and cross-lagged associations with weight across infancy, Appetite, 2023, 106978
- Discipline:
- Health Sciences
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- Creator:
- Rivera-Rivera, Luis Y., Moore, Timothy C., and Glotzer, Sharon C.
- Description:
- The dataset is organized as follows: the data for each of the three target structures is contained within a directory with the structure name (e.g., kagome, pyrocholore and snub-square). Within each structure directory, data obtained from alchemical and self-assembly simulations are separated into alchem and self-assembly directories respectively. An additional suboptimal-self-assembly directory is only present for the snub-square structure and contains the data for the pattern registration analysis discussed in the SI. For a detailed description of each file contained within each directory, please refer to the README file.
- Keyword:
- inverse design, self-assembly, triblock Janus particles, crystallization slot, and digital alchemy
- Citation to related publication:
- Rivera-Rivera, LY, Moore, TC & SC Glotzer. Inverse design of triblock Janus spheres for self-assembly of complex structures in the crystallization slot via digital alchemy. Soft Matter, 2023, 19, 2726-2736 doi: 10.1039/d2sm01593e
- Discipline:
- Engineering
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- Creator:
- Chenevert, Thomas L., Malyarenko, Dariya, Amouzandeh, Ghoncheh, Pickup, Stephen, Zhou, Rong, Manning, Henry Charles, Gamon, Seth T., Shoghi, Kooresh I., Quirk, James D., Sriram, Renuka, Larson, Peder, Lewis, Mickael T., Pautler, Robia G., Kinahan, Paul E., and Muzi, Mark
- Description:
- Goals of this work quantify repeatability and reproducibility across multiple NIH/NCI Co-Clinical Imaging Research Resources Program (CIRP) preclinical MRI systems in performing diffusion measurement using a standardized acquisition protocol on a shared phantom containing temperature-controlled medium of known diffusivity. To achieve these goals, the CIRP Image Acquisition Data Processing (IADP) working group (WG) performed a round-robin study of an ice water-based DWI phantom using a detailed phantom preparation procedure and standardized DWI acquisition protocol, with both site- and core-lab generated ADC measurements derived from shared datasets.
- Keyword:
- diffusion MRI, pre-clinical MRI, apparent diffusion coefficient (ADC), repeatability, reproducibility, and accuracy
- Citation to related publication:
- Tomography 2023, 9, 375–386. https://doi.org/10.3390/tomography9010030
- Discipline:
- Health Sciences
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- Creator:
- Umaña, Maria, Swenson, Nathan G, and Arellano, Gabriel
- Description:
- Identifying the functional traits that enable recovery after extreme events is necessary for assessing forest persistence and functioning, yet this is a difficult task because the traits mediating the responses to disturbance may vary depending on the disturbance type and over time. This study investigates the effects of traits on tree growth –for short and longer terms– in response to two vastly different extreme climatic events, droughts, and hurricanes, in a Puerto Rican forest.
- Keyword:
- Tropical tree, relative growth rates , and Puerto Rico
- Citation to related publication:
- Umaña, M. N. In review. The interplay of drought and hurricanes on tree recovery: insights from dynamic and weak functional responses. Forthcoming and Umana, M. (2023). Functional trait data across an elevational gradient of six tree species in El Yunque National Park, Puerto Rico in 2015 [Data set], University of Michigan - Deep Blue Data. https://doi.org/10.7302/7962-4t98
- Discipline:
- Science
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- Creator:
- Ludlow, Andrew and Kim, Jeongjin
- Description:
- Part of the regulation of telomerase activity includes the alternative splicing (AS) of the catalytic subunit telomerase reverse transcriptase (TERT). Although a therapeutic window for telomerase/TERT inhibition exists between cancer cells and somatic cells, stem cells express TERT and rely on telomerase activity for physiological replacement of cells. Therefore, identifying differences in TERT regulation between stem cells and cancer cells is essential for developing telomerase inhibition-based cancer therapies that reduce damage to stem cells. In this study, we measured TERT splice variant expression and telomerase activity in induced pluripotent stem cells (iPSCs), neural progenitor cells (NPCs), and non-small cell lung cancer cells (NSCLC, Calu-6 cells). We observed that a NOVA1-PTBP1-PTBP2 axis regulates TERT alternative splicing (AS) in iPSCs and their differentiation into NPCs. We also found that splice-switching of TERT, which regulates telomerase activity, is induced by different cell densities in stem cells but not cancer cells. Lastly, we identified cell type-specific splicing factors that regulate TERT AS. Overall, our findings represent an important step forward in understanding the regulation of TERT AS in stem cells and cancer cells. These data and subsequent studies may reveal a splicing factor(s) or their binding site(s) that could be targeted with small molecule drugs or antisense oligonucleotides, respectively, to reduce telomerase activity in cancer cells and promote durable cancer remissions.
- Keyword:
- Telomere, telomerase, TERT, alternative RNA splicing
- Citation to related publication:
- Dynamics of TERT Regulation via Alternative Splicing in Stem Cells and Cancer Cells. Accepted in Plos One
- Discipline:
- Science
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- Creator:
- Xu, Ying and Bradford, Nora
- Description:
- The data was collected from a survey study using Qualtrics described above. The data are in .csv format along with a codebook also in .csv format.
- Keyword:
- social chatbot, perception, and artificial intelligence
- Discipline:
- Social Sciences
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- Creator:
- Martin, Tara L, Young, LR, Goldsteen, D, Nunamaker, EA, Reynolds, P, Thompson-Iritani, S, Thurston, SE, and LaFollette, MR
- Description:
- This dataset contains the results of a survey of mouse handling methods by personnel working with laboratory mice. The survey included questions about preferred handling methods, barriers to use of refined handling methods, and a knowledge quiz about refined mouse handling. Data was collected via Qualtrics survey as described in the methodology section. This dataset is associated with the following publication, accepted by PLOS One: PONE-D-23-01633R1 Title: Using refined methods to pick up mice: A survey benchmarking prevalence & beliefs about tunnel and cup handling Authors: Lauren Young, Donna Goldsteen, Elizabeth A. Nunamaker, Mark J. Prescott, Penny Reynolds, Sally Thompson-Iritani, Sarah E. Thurston, Tara L. Martin, Megan R. LaFollette
- Keyword:
- Mouse, Refined Handling, Tunnel Handling, Cup Handling, Laboratory Animal, and Animal Care
- Citation to related publication:
- Young LR, Goldsteen D, Nunamaker EA, Prescott MJ, Reynolds P, Thompson-Iritani S, Thurston SE, Martin TL, LaFollette MR. Using refined methods to pick up mice: A survey benchmarking prevalence & beliefs about tunnel and cup handling. PLOS ONE. 2023. In Press.
- Discipline:
- Science
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- Creator:
- Matt, Cayenne, Gültekin, Kayhan, and Simon, Joseph
- Description:
- The data were used to create number density functions of supermassive black holes (SMBH) for redshifts 0.5 < z < 3.0. The goal of this research is to discern whether galaxy-black hole scaling relations produce black hole masses that are consistent with each other at high redshift. These number density functions were used to compare the high-mass SMBH distributions from each relation. In massive black hole binary based models, the highest-mass SMBHs have a significant influence on the gravitational wave background characteristic strain amplitude. To inform our understanding of the gravitational wave background, that pulsar timing arrays now show evidence for, we need to therefore have a solid foundation on the underlying SMBH population. In our paper we found that using different galaxy properties to inform our estimations of SMBH mass resulted in different distributions, especially at the high-mass end.
- Citation to related publication:
- https://iopscience.iop.org/article/10.1088/0067-0049/219/1/8, https://iopscience.iop.org/article/10.1088/0067-0049/196/1/11, https://iopscience.iop.org/article/10.1088/0004-637X/788/1/28, https://iopscience.iop.org/article/10.3847/1538-4357/ab7e27, and https://ui.adsabs.harvard.edu/abs/2023arXiv230704878M/abstract
- Discipline:
- Science