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- Creator:
- Umaña, Maria, Swenson, Nathan G, and Arellano, Gabriel
- Description:
- Identifying the functional traits that enable recovery after extreme events is necessary for assessing forest persistence and functioning, yet this is a difficult task because the traits mediating the responses to disturbance may vary depending on the disturbance type and over time. This study investigates the effects of traits on tree growth –for short and longer terms– in response to two vastly different extreme climatic events, droughts, and hurricanes, in a Puerto Rican forest.
- Keyword:
- Tropical tree, relative growth rates , and Puerto Rico
- Citation to related publication:
- Umaña, M. N. In review. The interplay of drought and hurricanes on tree recovery: insights from dynamic and weak functional responses. Forthcoming and Umana, M. (2023). Functional trait data across an elevational gradient of six tree species in El Yunque National Park, Puerto Rico in 2015 [Data set], University of Michigan - Deep Blue Data. https://doi.org/10.7302/7962-4t98
- Discipline:
- Science
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- Creator:
- Ludlow, Andrew and Kim, Jeongjin
- Description:
- Part of the regulation of telomerase activity includes the alternative splicing (AS) of the catalytic subunit telomerase reverse transcriptase (TERT). Although a therapeutic window for telomerase/TERT inhibition exists between cancer cells and somatic cells, stem cells express TERT and rely on telomerase activity for physiological replacement of cells. Therefore, identifying differences in TERT regulation between stem cells and cancer cells is essential for developing telomerase inhibition-based cancer therapies that reduce damage to stem cells. In this study, we measured TERT splice variant expression and telomerase activity in induced pluripotent stem cells (iPSCs), neural progenitor cells (NPCs), and non-small cell lung cancer cells (NSCLC, Calu-6 cells). We observed that a NOVA1-PTBP1-PTBP2 axis regulates TERT alternative splicing (AS) in iPSCs and their differentiation into NPCs. We also found that splice-switching of TERT, which regulates telomerase activity, is induced by different cell densities in stem cells but not cancer cells. Lastly, we identified cell type-specific splicing factors that regulate TERT AS. Overall, our findings represent an important step forward in understanding the regulation of TERT AS in stem cells and cancer cells. These data and subsequent studies may reveal a splicing factor(s) or their binding site(s) that could be targeted with small molecule drugs or antisense oligonucleotides, respectively, to reduce telomerase activity in cancer cells and promote durable cancer remissions.
- Keyword:
- Telomere, telomerase, TERT, alternative RNA splicing
- Citation to related publication:
- Dynamics of TERT Regulation via Alternative Splicing in Stem Cells and Cancer Cells. Accepted in Plos One
- Discipline:
- Science
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- Creator:
- Xu, Ying and Bradford, Nora
- Description:
- The data was collected from a survey study using Qualtrics described above. The data are in .csv format along with a codebook also in .csv format.
- Keyword:
- social chatbot, perception, and artificial intelligence
- Discipline:
- Social Sciences
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- Creator:
- Martin, Tara L, Young, LR, Goldsteen, D, Nunamaker, EA, Reynolds, P, Thompson-Iritani, S, Thurston, SE, and LaFollette, MR
- Description:
- This dataset contains the results of a survey of mouse handling methods by personnel working with laboratory mice. The survey included questions about preferred handling methods, barriers to use of refined handling methods, and a knowledge quiz about refined mouse handling. Data was collected via Qualtrics survey as described in the methodology section. This dataset is associated with the following publication, accepted by PLOS One: PONE-D-23-01633R1 Title: Using refined methods to pick up mice: A survey benchmarking prevalence & beliefs about tunnel and cup handling Authors: Lauren Young, Donna Goldsteen, Elizabeth A. Nunamaker, Mark J. Prescott, Penny Reynolds, Sally Thompson-Iritani, Sarah E. Thurston, Tara L. Martin, Megan R. LaFollette
- Keyword:
- Mouse, Refined Handling, Tunnel Handling, Cup Handling, Laboratory Animal, and Animal Care
- Citation to related publication:
- Young LR, Goldsteen D, Nunamaker EA, Prescott MJ, Reynolds P, Thompson-Iritani S, Thurston SE, Martin TL, LaFollette MR. Using refined methods to pick up mice: A survey benchmarking prevalence & beliefs about tunnel and cup handling. PLOS ONE. 2023. In Press.
- Discipline:
- Science
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- Creator:
- Matt, Cayenne, Gültekin, Kayhan, and Simon, Joseph
- Description:
- The data were used to create number density functions of supermassive black holes (SMBH) for redshifts 0.5 < z < 3.0. The goal of this research is to discern whether galaxy-black hole scaling relations produce black hole masses that are consistent with each other at high redshift. These number density functions were used to compare the high-mass SMBH distributions from each relation. In massive black hole binary based models, the highest-mass SMBHs have a significant influence on the gravitational wave background characteristic strain amplitude. To inform our understanding of the gravitational wave background, that pulsar timing arrays now show evidence for, we need to therefore have a solid foundation on the underlying SMBH population. In our paper we found that using different galaxy properties to inform our estimations of SMBH mass resulted in different distributions, especially at the high-mass end.
- Citation to related publication:
- https://iopscience.iop.org/article/10.1088/0067-0049/219/1/8, https://iopscience.iop.org/article/10.1088/0067-0049/196/1/11, https://iopscience.iop.org/article/10.1088/0004-637X/788/1/28, https://iopscience.iop.org/article/10.3847/1538-4357/ab7e27, and https://ui.adsabs.harvard.edu/abs/2023arXiv230704878M/abstract
- Discipline:
- Science
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- Creator:
- Lumeng, Julie C
- Description:
- Healthy full-term infants were enrolled in a longitudinal study designed to examine the development of infant eating behavior. Infant weight and length was measured, mothers completed questionnaires regarding infant eating behaviors, and infant capacity for regulation of energy intake was evaluated by comparing intake between two days: one with feedings given on demand and one with feedings offered hourly. The infant's ability to downregulate intake in response to more frequent feedings was calculated.
- Keyword:
- infant, eating, weight gain, feeding, and energy regulation
- Citation to related publication:
- Reynolds, L. A., McCaffery, H., Appugliese, D., Kaciroti, N. A., Miller, A. L., Rosenblum, K. L., ... & Lumeng, J. C. (2023). Capacity for Regulation of Energy Intake in Infancy. JAMA pediatrics, 177(6), 590-598.
- Discipline:
- Health Sciences
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- Creator:
- Lumeng, Julie C
- Description:
- Healthy full-term infants were enrolled in a longitudinal study designed to examine the development of infant eating behavior. Infant weight and length was measured, mothers completed questionnaires regarding infant eating behaviors, and infant sucking behavior was quantified using the NFANT device during a typical feeding. The predictive value of the NFANT-generated sucking metrics for infant weight gain was evaluated.
- Keyword:
- infant, eating, weight gain, and sucking
- Citation to related publication:
- Feldman, Keith, Katharine Asta, Ashley N. Gearhardt, Julie M. Sturza, Danielle Appugliese, Alison L. Miller, Katherine Rosenblum, Kai Ling Kong, Amanda K. Crandall, and Julie C. Lumeng. "Characterization of a Vigorous sucking style in early infancy and its predictive value for weight gain and eating behaviors at 12 months." Appetite (2023): 106525.
- Discipline:
- Health Sciences
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ABC Baby Study
User Collection
- Creator:
- Lumeng, Julie C
- Description:
- The primary goal of this project was to identify domains of infant eating behavior and their trajectories over the first year of life. A convenience sample of 284 mother-infant dyads was recruited and enrolled from communities within a 1-hour driving distance of Ann Arbor, Michigan, via social media; flyers in outpatient pediatric clinics and community settings; and targeted outreach by telephone, email, and mail to pregnant women and mothers of newborn infants receiving care within the University of Michigan health system between October 2015 and February 2019. The planned sample size was based on a priori power calculations anticipating 3-5 eating behavior factors, each with 3 different trajectories, providing 81% power to detect a 10% or more change in the likelihood of exhibiting one of an anticipated 3 trajectory patterns of infant growth; the ultimate sample size of 284 was based on feasibility related to recruitment and retention. , The study included a repeated-measures, within-participant experimental design embedded within a longitudinal observational cohort study. The goal was to examine the development of infant eating behavior longitudinally at ages 0.5, 2, 4, 6, 9 and 12 months based on data collected from questionnaires, eating behavior experiments, and anthropometry via home visits by trained research staff. The study was described to participants as seeking to understand infant eating behavior and interactions between mothers and babies in the first year after birth. Inclusion criteria were gestational age of 37.0 to 42.0 weeks, weight appropriate for gestational age, no significant perinatal or neonatal complications, biological mother was the legal and custodial guardian, and infant’s having had consumed 2 oz or more in 1 feeding from an artificial nipple at least once per week. Exclusion criteria were mother not fluent in English; mother younger than 18 years; infant medical problems or diagnosis affecting current or future eating, growth, or development; or child protective services involvement. Mothers provided written informed consent for themselves and their infants. The study was approved by the University of Michigan institutional review board. To facilitate recruitment, dyads could be enrolled at 1 of 3 age points up to and including age 4 months; data collected at enrollment are referred to as baseline. , and Mothers responded to questionnaires on demographics, psychosocial stress, perinatal history, feeding behaviors and practices, sleep, their own eating behaviors, infant temperament, their own and the infant’s diet, and infant eating behaviors. Maternal and infant anthropometry was measured by trained research assistants. Mother-infant dyads participated in protocols designed to measure infant response to sucrose, infant ability to delay gratification, infant response to a challenging feeding, the relative reinforcing value of food, eating in the absence of hunger, capacity for regulation of energy intake in response to more frequent feedings and in response to increased caloric density, and response to novel and familiar foods. Maternal feeding behaviors were also coded from video. Biological samples included infant stool and maternal breastmilk.
- Keyword:
- infant, eating, weight gain, and sucking
- Discipline:
- Health Sciences
4Works -
- Creator:
- Lojko, Alexander, Zhang, Yingxiao, Whitcomb, Morgan, Yang, Emily, Dacic, Natasha, and Holmes, Janelle
- Description:
- GIS (.lpkx) data layers that inform of areas to construct new rain gardens in Washtenaw County, Ann Arbor, Michigan. Data layers can be opened with a GIS program. There is a single .lpkx dataset that contains four layers. The first layer contains 'Wildlife Corridors' which contains information on where to prioritize new green infrastructure based on how well-connected different patches of forested areas are. The second layer, 'Social Inequality', shows where to prioritize new rain gardens based on social inequality criteria. The 'Creeksheds and Future Runoff' contains information on future changes in precipitation runoff based on climate change projections of rainfall. Lastly, 'Runoff/Water Quality' is a layer that includes a priority map regarding where new rain gardens should be developed based on areas that are most at risk of poor water quality and enhanced surface run-off. The project was completed for Washtenaw County Water Resources as part of a course taught at the University of Michigan, CLIMATE 592. A description of the course is also provided: "Introduction to individual and team research on real-world problems in the area of applied climate. On a research project started in CLIMATE 591 and guided by a mentor from a commercial or government laboratory, students will apply the principles of risk analysis and objective assessment of adaptive strategies".
- Keyword:
- GIS, Climate Change, Local, Community, and Graduate Student Project
- Citation to related publication:
- Dacic, N., Lojko, A., Zhang, Y., Yang, E., Whitcomb, M., Bassis, J., and Rood., R.B., 2023 'Modernizing the Climate Science Curriculum: Engaging in Local Government Collaboration Projects', In Preperation for the Bulletin of American Meteorological Society
- Discipline:
- Science
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- Creator:
- Raghani, Ravi M, Urie, Russell R, and Shea, Lonnie D
- Description:
- The IN were sampled during and after ICB and sequenced to identify gene expression signatures that correlated with sensitivity or resistance. We also analyzed gene expression at the IN prior to ICB treatment to identify markers predicting therapeutic response. Longitudinally interrogating an IN, to monitor changes associated with ICB response, presents a new opportunity to personalize care and investigate mechanisms underlying treatment resistance.
- Keyword:
- Immunotherapy resistance, Biomaterials, Metastasis, Checkpoint blockade, and Therapy monitoring
- Discipline:
- Engineering and Health Sciences