Search Constraints
Number of results to display per page
View results as:
Search Results
-
- Creator:
- Zongyu Li, Yuni K. Dewaraja, and Jeffrey A. Fessler
- Description:
- Current methods for patient-specific voxel-level dosimetry in radionuclide therapy suffer from a trade-off between accuracy and computational efficiency. Monte Carlo (MC) radiation transport algorithms are considered the gold standard for voxel-level dosimetry but can be computationally expensive, whereas faster dose voxel kernel (DVK) convolution can be sub-optimal in the presence of tissue heterogeneities. Furthermore, the accuracies of both these methods are limited by the spatial resolution of the reconstructed emission image. To overcome these limitations, this paper considers a single deep convolutional neural network (CNN) with residual learning (named DblurDoseNet) that learns to produce dose-rate maps while compensating for the limited resolution of SPECT images. We took the novel approach of constructing a convolutional neural network with residual learning to handle the accuracy-efficiency tradeoff while compensating for the limited resolution of SPECT images. We then test our CNN on clinically relevant phantoms and patients undergoing Lu-177 DOTATATE therapy in our clinic. Our network demonstrated superior results than Monte Carlo, the current gold standard for voxel dosimetry, but only takes a fraction of time. Thus, the DblurDoseNet has the potential for real-time patient-specific dosimetry in clinical treatment planning due to its demonstrated improvement in accuracy, resolution, noise and speed over the DVK/MC approaches. Matlab is needed to access the phantoms and Python (with Numpy package installed) is needed to access the DVKs.
- Keyword:
- Deep learning, Voxel-level dosimetry, Lu-177 therapy, SPECT resolution effects
- Citation to related publication:
- "DblurDoseNet: A Deep Residual Learning Network for Voxel Radionuclide Dosimetry Compensating for SPECT Imaging Resolution" by Zongyu Li, Jeffrey A. Fessler, Justin K. Mikell, Scott J. Wilderman and Yuni K. Dewaraja. Accepted by Medical Physics, 2021. DOI: 10.1002/mp.15397
- Discipline:
- Health Sciences
-
- Creator:
- Bhaumik, Deesha
- Description:
- This cross-sectional analysis included 584 participants in the Center for Oral Health Research in Appalachia cohort 1 (COHRA1). We sequenced the V4 region of the 16S rRNA of supragingival plaque from 185 caries-active and 565 caries-free teeth using the Illumina MiSeq platform. Sequences were filtered using the R DADA2 package and assigned taxonomy using the Human Oral Microbiome Database ( http://www.homd.org/).
- Keyword:
- Amplicon Sequence Variant
- Citation to related publication:
- In press
- Discipline:
- Health Sciences
-
- Creator:
- Lee, Dahee, Panicker, Veena, and Landis-Lewis, Zach
- Description:
- We use the term “performance summary display” (PSD) to mean a kind of visualization that relates performance levels to other types of information. In the context of healthcare organizations, PSDs are intended to be communicated to a healthcare professional, team, or organization. and Displays were identified, classified, and elements counted and coded. The performance summary display ontology provides a set of descriptions of components of displays that have been used to annotate performance feedback visualizations.
- Keyword:
- Performance
- Citation to related publication:
- Lee, D., Panicker, V., Gross, C., Zhang, J., & Landis-Lewis, Z. (2020). What was visualized? A method for describing content of performance summary displays in feedback interventions. BMC medical research methodology, 20(1), 90. https://doi.org/10.1186/s12874-020-00951-x
- Discipline:
- Health Sciences and Science
-
- Creator:
- LaBarre, Jennifer L., Peterson, Karen E., Kachman, Maureen T., Perng, Wei., Tang, Lu., Hao, Wei., Zhou, Ling., Karnovsky, Alla., Cantoral, Alejandra., Téllez-Rojo, Martha María., Song, Peter XK., and Burant, Charles F.
- Description:
- Participants were enrolled in the Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) project which was started in 1994 and consists of three sequentially-enrolled birth cohorts from Mexico City Maternity Hospitals (20). A subset of these children, age 8-14 years, were contacted through their primary caregiver to provide urine samples, serum samples, anthropometry and complete an interview-based questionnaire (n=250). Subjects for this analysis have baseline and follow data on anthropometry, metabolic biomarkers and adequate serum volume for metabolomics analyses (n=206).
- Citation to related publication:
- LaBarre, J. L., Peterson, K. E., Kachman, M. T., Perng, W., Tang, L., Hao, W., Zhou, L., Karnovsky, A., Cantoral, A., Téllez-Rojo, M. M., Song, P. X. K., & Burant, C. F. (2020). Mitochondrial Nutrient Utilization Underlying the Association Between Metabolites and Insulin Resistance in Adolescents. The Journal of Clinical Endocrinology & Metabolism, 105(7), 2442–2455. https://doi.org/10.1210/clinem/dgaa260
- Discipline:
- Health Sciences
-
- Creator:
- Harper Diane M
- Description:
- Patients included in this study were all males with no prior HIV diagnosis between 18 and 45 years who had at least one primary care encounter between March 2016 and March 2019. We chose 2016 as the index year because the question of the sexual partners’ gender became coded data elements with the clinic contact. Eligible patients were grouped based on reported sexual partners at the most recent disclosure. Individuals who reported having a male sexual partner or both a male and female partner were included in the MSM group. The non-MSM group included individuals who reported only a female partner or no partner. Patients who did not answer the question were excluded from the study. The study proposal was submitted to the Institutional Review Boards of the University of Michigan Medical School and was exempted from ongoing IRB review (HUM00155091). Individual consent was waived for this study.
- Keyword:
- HIV, MSM, and annual screening
- Discipline:
- Health Sciences
-
- Creator:
- Gradwohl, Kelsey M.
- Description:
- The data set includes one file: Dermatology Clerkship Chalk Talks Raw Dataset which is the raw data collected from the surveys. This raw data was then coded and scored with the following analysis. Objective knowledge questions were asked for each chalk talk which was scored by authors. A knowledge assessment score was calculated by adding the total number of points accumulated by the student, dividing it by the total number of points possible, and summarizing the score as a percentage. Pre- and post-talk knowledge assessment scores were compared for each chalk talk and for the entire curriculum using 2-tailed paired sample t-tests with statistical significance if p<0.05., Before and after each talk, students were asked how confident they felt differentiating conditions within each disease group. For the erythroderma and immunobullous talks, students were also asked how confident they felt working up the conditions. Answer choices were on a Likert scale ranging from 1 (not at all confident) to 5 (extremely confident). Pre- and post-chalk talk scores were summarized as means with standard deviations and compared using 2-tailed paired sample t-tests with statistical significance if p<0.05. , After each talk, students were asked about its efficacy in terms of enhancing their understanding of the diseases, providing a framework or approach to work-up, and facilitating interaction between student and teacher. Answer choices were on a Likert scale ranging from 1 (not at all effective) to 5 (extremely effective), and summarized as means with standard deviations. Students were asked for written feedback regarding what they liked about the talk and suggestions for improvement. Qualitative data were sorted into categories and scored by two independent raters (cohen's kappa =0.8)., and In the response Likert scale, "Not at all"=1, "Not so (much)"=2, "Somewhat"=3, "Very"=4, and "Extremely"=5.
- Keyword:
- Chalk talk, Dermatology clerkship, Dermatology education, Virtual learning, and Online learning
- Discipline:
- Health Sciences
-
- Creator:
- Crisp, Dakota N., Parent, Rachel, Nakatani, Mitsuyoshi, Murphy, Geoffrey G. , and Stacey, William C.
- Description:
- This data and scripts are meant to test and show that seizure onset dynamics can be modulated using anti-epileptic drugs. A zip file is included that contains all waveform data, MATLAB processing scripts, and metadata. The MATLAB scripts allow for visual review validation and objective feature analysis. The file includes various README files explaining the scripts and their relationships in greater detail.
- Keyword:
- Bifurcation, Epilepsy, Seizure, and Electrophysiology
- Discipline:
- Health Sciences, Engineering, and Science
-
- Creator:
- Saylor, Kate M., Hicks, Patrice M., Kang, Linda, Stagg, Brian C., Newman-Casey, Paula-Anne, and Woodward, Maria A.
- Description:
- The search data supports a scoping literature review project on Loss to follow-up barriers in care for Cornea Ulcers and Glaucoma. The data included are the reproducible search strategies (txt file) and the exported results of all citations from all databases (txt, ris, and.nbib files). Both the original search files and updated search files have been included in the deposit.
- Keyword:
- Cornea, Glaucoma, Loss to follow, and ophthalmology
- Discipline:
- Health Sciences
-
- Creator:
- Saylor, Kate M., Sirihorachai, Rattima , and Manojlovich, Milisa
- Description:
- The search data supports a literature review project on counting interventions to reduce the incidence of retained surgical instruments. The data included in the dataset are the reproducible search strategies (txt file) and the exported results of all citations from all databases (txt, ris, and.nbib files). These searches and exported result files contain all citations originating from the database searches that were considered for inclusion.
- Keyword:
- literature search , retained surgical instruments, counting, and nursing
- Discipline:
- Health Sciences
-
- Creator:
- Attari, Ali
- Description:
- Please refer to the "README.txt" for more details., MATLAB R2018a (Mathworks, Natick, MA, USA) was used to process this data., and Excel (Microsoft Office) was used to store survey data on the comfort of both systems and also to provide absolute and relative intraobserver variablities for the DM device.
- Keyword:
- Digital Manometry
- Citation to related publication:
- Comparison of anorectal function measured using wearable digital manometry and a high resolution manometry system Attari A, Chey WD, Baker JR, Ashton-Miller JA (2020) Comparison of anorectal function measured using wearable digital manometry and a high resolution manometry system. PLOS ONE 15(9): e0228761. https://doi.org/10.1371/journal.pone.0228761
- Discipline:
- Engineering, Science, and Health Sciences