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- Creator:
- Brown, Kathryn
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication: https://doi.org/10.3998/mpub.10079890), and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , gateway , sitesucker , website, and file directory
- Citation to related publication:
- GERE, A. R. (Ed.). (2019). DEVELOPING WRITERS IN HIGHER EDUCATION: A longitudinal study. S.l.: UNIV OF MICHIGAN PRESS. https://doi.org/10.3998/mpub.10079890
- Discipline:
- Humanities
-
- Creator:
- Brown, Kathryn
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication: https://doi.org/10.3998/mpub.10079890), and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , capstone , sitesucker , website , and file directory
- Citation to related publication:
- GERE, A. R. (Ed.). (2019). DEVELOPING WRITERS IN HIGHER EDUCATION: A longitudinal study. S.l.: UNIV OF MICHIGAN PRESS. https://doi.org/10.3998/mpub.10079890
- Discipline:
- Humanities
-
- Creator:
- Adams, Julia
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication: https://doi.org/10.3998/mpub.10079890), and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , gateway , sitesucker , website , and file directory
- Citation to related publication:
- GERE, A. R. (Ed.). (2019). DEVELOPING WRITERS IN HIGHER EDUCATION: A longitudinal study. S.l.: UNIV OF MICHIGAN PRESS. https://doi.org/10.3998/mpub.10079890
- Discipline:
- Humanities
-
- Creator:
- Garno, Gregory
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication: https://doi.org/10.3998/mpub.10079890), and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , gateway , sitesucker, website , and file directory
- Citation to related publication:
- GERE, A. R. (Ed.). (2019). DEVELOPING WRITERS IN HIGHER EDUCATION: A longitudinal study. S.l.: UNIV OF MICHIGAN PRESS. https://doi.org/10.3998/mpub.10079890
- Discipline:
- Humanities
-
- Creator:
- Lisner, Emily
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication: https://doi.org/10.3998/mpub.10079890), and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , gateway , sitesucker , website , and file directory
- Citation to related publication:
- GERE, A. R. (Ed.). (2019). DEVELOPING WRITERS IN HIGHER EDUCATION: A longitudinal study. S.l.: UNIV OF MICHIGAN PRESS. https://doi.org/10.3998/mpub.10079890
- Discipline:
- Humanities
-
- Creator:
- Avesian, Erica
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication: https://doi.org/10.3998/mpub.10079890), and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , capstone, sitesucker, website , and file directory
- Citation to related publication:
- GERE, A. R. (Ed.). (2019). DEVELOPING WRITERS IN HIGHER EDUCATION: A longitudinal study. S.l.: UNIV OF MICHIGAN PRESS. https://doi.org/10.3998/mpub.10079890
- Discipline:
- Humanities
-
- Creator:
- Liang, Jun and Wang, Zihan
- Description:
- The aim of the research to study the temporal evolution of the Sub-Auroral Polarizations Streams (SAPS) with multiple instruments. Aurora images are important to identify the electrodynamics in the high latitude ionosphere. Data used in this research were collected and provided by Dr. Jun Liang at University of Calgary, and analyzed by Zihan Wang for the article accompanying this deposit. The data was collected from all sky imagers (ASI) located in Saskatoon, Canada. and saskrainbow01.sav contains the rgb channels from ASI. It can be opened using IDL. saskasiskymap.gm5 contains the sky map of the ASI. It shows the geographic location of the figure pixels. aurora_diff.pro is the procedure to recover the data from saskrainbow01.sav and make plots. draw_colorbar.pro is the procedure to add a colorbar to the plot. mlon_smp_towang.pro and rebinsmpkeo_towang.pro can together make keogram plots. Run mlon_smp_towang.pro first and then rebinsmpkeo_towang.pro.
- Keyword:
- All Sky Imager
- Citation to related publication:
- Wang, Z., Zou, S., Shepherd, S. G., Liang, J., Gjerloev, J. W., Ruohoniemi, J. M., et al. ( 2019). Multi‐instrument observations of mesoscale enhancement of subauroral polarization stream associated with an injection.Journal of Geophysical Research: Space Physics, 124, 1770– 1784. https://doi.org/10.1029/2019JA026535
- Discipline:
- Science
-
- Creator:
- Singer, Kanakadurga
- Description:
- Supplementary Figure 1. Tissue weights in response to HFD feeding and CL treatment. (A) GWAT weight as % of body weight (B) IWAT weight as % of body weight (C) BAT weight as % of body weight (D) Liver weight as % of body weight. N=7-12 /group; *p<0.05, **p<0.01, ***p<0.005, ****p<0.0001; error bars are SEM. Comparisons of M ND PBS vs F ND PBS are shown as #p<0.05, ##p<0.01, ###p<0.005 and M HFD PBS vs F HFD PBS are shown as &p<0.05, &&p<0.01, &&&p<0.005, &&&&p<0.0001., Supplementary Figure 2. Free glycerol estimation in lean and obese male and female WAT and BAT depot explants with ADRB3 stimulated lipolysis. Free glycerol estimation in lean and obese (A) GWAT (B) IWAT (C) BAT explant tissues. Free glycerol released calculated as fold change over basal conditions in lean and obese (D) GWAT (E) IWAT (F) BAT explant tissues. N=8 /group; *p<0.05, **p<0.01, ***p<0.005, ****p<0.0001; error bars are SEM. Comparisons of M ND PBS vs F ND PBS are shown as #p<0.05, ##p<0.01, ###p<0.005 and M HFD PBS vs F HFD PBS are shown as &p<0.05, &&p<0.01, &&&p<0.005, &&&&p<0.0001., Supplementary Figure 3. Gene expression (A) Akt1 and (B) Glut4 gene expression in obese male and female GWAT with and without ADRB3 stimulation. A.U., arbitrary units, N=5-8; *p<0.05, **p<0.01, ***p<0.005, ****p<0.0001., Supplementary Figure 4. Flow cytometry assessment of ATMs in lean and obese IWAT SVF. Quantitation of (A) IWAT percent ATMs (B) IWAT CD11c+ ATMs (C) IWAT CD11c-ATMs (D) IWAT dendritic cells (DC) numbers, N=7-12/group; *p<0.05, **p<0.01, ***p<0.005, ****p<0.0001. , Supplementary Figure 5. Lipidomic assessment of lipid mediators in obese male and female GWAT. (A) Relative hydroxy fatty acids (FAHFA) (B) Phosphatidylserine (PS) (C) Phosphatidylcholine (PC) (D) Lyso-PC (E) Phosphatidylethanolamine (PE) (F) Phosphatidylglycerol (PG) (G) Phosphatidylinositol (PI) content in obese male and female GWAT with and without CL treatment. N=6/group; *p<0.05, **p<0.01, ***p<0.005, ****p<0.0001., and Curation note: Title of deposit changed from "Supplementary Materials Lipolysis Paper" Dec. 20, 2018 to more closely reflect association with the paper these materials support.
- Citation to related publication:
- Mita Varghese, Cameron Griffin, Kaitlin McKernan, Leila Eter, Nicholas Lanzetta, Devyani Agarwal, Simin Abrishami, Kanakadurga Singer, Sex Differences in Inflammatory Responses to Adipose Tissue Lipolysis in Diet-Induced Obesity, Endocrinology, Volume 160, Issue 2, February 2019, Pages 293–312, https://doi.org/10.1210/en.2018-00797
- Discipline:
- Science
-
- Creator:
- Ramasubramani, Vyas
- Description:
- The goal of the work is to elucidate the stability of a complex experimentally observed structure of proteins. We found that supercharged GFP molecules spontaneously assemble into a complex 16-mer structure that we term a protomer, and that under the right conditions an even larger assembly is observed. The protomer structure is very well defined, and we performed simulations to try and understand the mechanics underlying its behavior. In particular, we focused on understanding the role of electrostatics in this system and how varying salt concentrations would alter the stability of the structure, with the ultimate goal of predicting the effects of various mutations on the stability of the structure. There are two separate projects included in this repository, but the two are closely linked. One, the candidate_structures folder, contains the atomistic outputs used to generate coarse-grained configurations. The actual coarse-grained simulations are in the rigid_protein folder, which pulls the atomistic coordinates from the other folder. All data is managed by signac and lives in the workspace directories, which contain various folders corresponding to different parameter combinations. The parameters associated with a given folder are stored in the signac_statepoint.json files within each subdirectory. The atomistic data uses experimentally determined protein structures as a starting point; all of these are stored in the ConfigFiles folder. The primary output is the topology files generated from the PDBs by GROMACS; these topologies are then used to parametrize the Monte Carlo simulations. In some cases, atomistic simulations were actually run as well, and the outputs are stored alongside the topology files. In the rigid_protein folder, the ConfigFiles folder contains MSMS, the software used to generate polyhedral representations of proteins from the PDBs in the candidate_structures folder. All of the actual polyhedral structures are also stored in the ConfigFiles folder. The actual simulation trajectories are stored as general simulation data (GSD) files within each subdirectory of the workspace, along with a single .pos file that contains the shape definition of the (nonconvex) polyhedron used to represent a protein. The logged quantities, such as energies and MC move sizes, are stored in .log files. The logic for the simulations in the candidate_structures project is in the Python scripts project.py, operations.py, and scripts/init.py. The rigid_protein folder also includes the notebooks directory, which contains Jupyter notebooks used to perform analyses, as well as the Python scripts used to actually perform the simulations and manage the data space. In particular, the project.py, operations.py and scripts/init.py scripts contain most of the logic associated with the simulations.
- Keyword:
- Protein assembly, Cryo TEM, Hierarchical Assembly, Monte Carlo simulation, and Coarse-grained simulation
- Citation to related publication:
- Anna J Simon, Vyas Ramasubramani, Jens Glaser, Arti Pothukuchy, Jillian Gerberich, Janelle Leggere, Barrett R Morrow, Jimmy Golihar, Cheulhee Jung, Sharon C Glotzer, David W Taylor, Andrew D Ellington,"Supercharging enables organized assembly of synthetic biomolecules," bioRxiv 323261; doi: https://doi.org/10.1101/323261
- Discipline:
- Science and Engineering
-
- Creator:
- R Paul Drake
- Description:
- The specific focus of the project was radiative shocks, which develop when shock waves become so fast and hot that the radiation from the shocked matter dominates the energy transport. This in turn leads to changes in the shock structure. Radiative shocks are challenging to simulate, as they include phenomena on a range of spatial and temporal scales and involve two types of nonlinear physics Ð- hydrodynamics and radiation transport. Even so, the range of physics involved is narrow enough that one can hope to model all of it with sufficient fidelity to reproduce the data. CRASH was focused on developing predictions for a sequence of experiments performed in Project Year 5, in which those experiments represented an extrapolation from all previously available data. The previous data involved driving radiative shocks within cylindrical structures, and mainly straight tubes. The Year 5 experiments drove a radiative shock down an elliptical tube. Our long-stated goal for these predictions was that the distribution of predicted values would overlap significantly with the observed distribution. We achieved this goal. Achieving our goal required the conversion of an established space-weather code to model radiative shocks at high energy density. To obtain reasonable fidelity with respect to the experimental data required implementing a laser absorption package, in addition to a hydrodynamic solver, electron physics and heat conduction, and multigroup diffusive radiation transport. The dedicated experiments provided evidence of experimental variability, validation of the calculation of initial shock wave behavior, and validation data at many observation times using cylindrical shock tubes. Following this were preparatory experiments for and finally the execution of the Year 5 experiments. The predictive science research included a wide range of sensitivity studies to determine which variables were important and a sequence of predictive studies focused on specific issues and sets of data. This led ultimately to predictions of shock location for the Year 5 experiments. A conclusion from this project is that the serious quantification of uncertainty in simulations is a dauntingly difficult and expensive prospect. Pre-existing codes are unlikely to have been built with attention to what will be needed to quantify their uncertainty. Pre-existing experimental results are even more unlikely to include a sufficiently detailed analysis of the experimental uncertainties. And this will also be true of most experiments that might be used to validate components of the simulation. The analysis of uncertainty in any one of the physical processes (and related physical constants) is a major effort. And addressing model form uncertainty is an even bigger challenge, that may in principle require development of complete, alternative simulation models. We made a start at all of this, and completed almost none of it. But by the end of a project, we finally had all the pieces in place and working that would have enabled a range of important studies and advances in relatively near-term years. But the sponsor terminated the program after only five years. For most of the participants this was a relatively minor development, although for a few of them it proved to be enormously disruptive. We believe that the cost to the nation, in work that was ready be done but now will not be, was much much larger. The sketch of the target was produced using a drawing program based on the experimental dimensions. The annotated photograph of the target was obtained using a visible-light camera. The colorized radiographs were obtained via backilit-pinhole radiography of a radiative shock propagating down an elliptical tube, at 26 ns after the lasers driving the shock tube fired. The graph showing lines and circles was produced by running many computer models, analyzing their statistical distribution, and measuring actual shock positions in the experiment.
- Keyword:
- Radiative shock
- Citation to related publication:
- R.P. Drake, F.W. Doss, R.G. McClarren, M.L. Adams, N. Amato, D.Bingham, C.C. Chou, C. DiStefano, K. Fidkowsky, B. Fryxell, T.I.Gombosi, M.J. Grosskopf, J.P. Holloway, B. van der Holst, C.M.Huntington, S. Karni, C.M. Krauland, C.C. Kuranz, E. Larsen, B. vanLeer, B. Mallick, D. Marion, W. Martin, J.E. Morel, E.S. Myra, V. Nair, K.G. Powell, L. Raushberger, P. Roe, E. Rutter, I.V. Sokolov, Q. Stout, B.R. Torralva, G. Toth, K. Thornton, A.J. Visco, “Radiative Effects in Radiative Shocks in Shock Tubes”, High Energy Density Physics 7, 130-140 (2011) https://doi.org/10.1016/j.hedp.2011.03.005
- Discipline:
- Science