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- Creator:
- Skerlos, Steven J.
- Description:
- Supporting Information for research article "Life cycle comparison of environmental emissions from three disposal options for unused pharmaceutical". This spreadsheet provides the calculations and values used for this study; please refer to the manuscript and supporting information (as text) available at http://dx.doi.org/10.1021/es203987b for details about how to use this spreadsheet. We use life cycle assessment methodology to compare three disposal options for unused pharmaceuticals: (i) incineration after take-back to a pharmacy, (ii) wastewater treatment after toilet disposal, and (iii) landfilling or incineration after trash disposal. For each option, emissions of active pharmaceutical ingredients to the environment (API emissions) are estimated along with nine other types of emissions to air and water (non-API emissions). Under a scenario with 50% take-back to a pharmacy and 50% trash disposal, current API emissions are expected to be reduced by 93%. This is within 6% of a 100% trash disposal scenario, which achieves an 88% reduction. The 50% take-back scenario achieves a modest reduction in API emissions over a 100% trash scenario while increasing most non-API emissions by over 300%. If the 50% of unused pharmaceuticals not taken-back are toileted instead of trashed, all emissions increase relative to 100% trash disposal. Evidence suggests that 50% participation in take-back programs could be an upper bound. As a result, we recommend trash disposal for unused pharmaceuticals. A 100% trash disposal program would have similar API emissions to a take-back program with 50% participation, while also having significantly lower non-API emissions, lower financial costs, higher convenience, and higher compliance rates.
- Citation to related publication:
- Cook, Sherri M., Bryan J. VanDuinen, Nancy G. Love, and Steven J. Skerlos. “Life Cycle Comparison of Environmental Emissions from Three Disposal Options for Unused Pharmaceuticals.” Environmental Science & Technology 46, no. 10 (May 15, 2012): 5535–41. https://doi.org/10.1021/es203987b
- Discipline:
- Engineering
-
- Creator:
- Dr. Francis C. Evans
- Description:
- The Evans Old Field Plant Database contains FileMaker and Excel files of data collected by Dr. Francis C. Evans during a 50-year study on successional change on Evans Old Field on the Edwin S. George Reserve. Data include plant phenology, location, and abundances observed from 1948 to 1997.
- Discipline:
- Science
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- Creator:
- Zurbuchen, Thomas H.
- Description:
- Audification Routines in MATLAB and IDL
- Citation to related publication:
- Alexander, Robert L., Sile O’Modhrain, D. Aaron Roberts, Jason A. Gilbert, and Thomas H. Zurbuchen. “The Bird’s Ear View of Space Physics: Audification as a Tool for the Spectral Analysis of Time Series Data.” Journal of Geophysical Research: Space Physics 119, no. 7 (2014): 5259–71. https://doi.org/10.1002/2014JA020025
- Discipline:
- Science
-
- Creator:
- Keener, Alix
- Description:
- As discussion and debates on the digital humanities continue among scholars, so too does discussion about how academic libraries can and should support this scholarship. Through interviews with digital humanities scholars and academic librarians within the Center for Institutional Cooperation, this study aims to explore some points of common perspective and underlying tensions in research relationships. Qualitative interviews revealed that, while both groups are enthusiastic about the future of faculty-librarian collaboration on digital scholarship, there remain certain tensions about the role of the library and the librarian. Scholars appreciate the specialized expertise of librarians, especially in metadata and special collections, but they can take a more active stance in utilizing current library resources or vocalizing their needs for other resources. This expertise and these services can be leveraged to make the library an active and equal partner in research. Additionally, libraries should address internal issues, such as training and re-skilling librarians as necessary; better-coordinated outreach to academic departments is also needed.
- Citation to related publication:
- Alix Keener, "The Arrival Fallacy: Collaborative Research Relationships in the Digital Humanities," Digital Humanities Quarterly vol. 9 no. 2 (2015), http://www.digitalhumanities.org/dhq/vol/9/2/000213/000213.html
- Discipline:
- Humanities
-
- Creator:
- University of Michigan Transportation Research Institute, Rupp, Jonathan D., Klein, Katelyn F., and Reed, Matthew P.
- Description:
- The files include an Excel file with the x-, y-, and z- coordinates that make up the nodal coordinates for a surface model of small (5th percentle) female pelvis geometry, the finite element model (.k file) that represents the nodal coordinates, and two surface files that represent the geometry (.obj and .ply).
- Citation to related publication:
- Katelyn F. Klein, Matthew P. Reed, and Jonathan D. Rupp. "Development of Geometric Specifications for the Pelvis of a Small Female Anthropomorphic Test Device." IRCOBI Conference 2016, IRC-16-79. http://www.ircobi.org/wordpress/downloads/irc16/pdf-files/79.pdf
- Discipline:
- Engineering
-
- Creator:
- Carson IV, William F.
- Description:
- Raw data and analysis files for the figures corresponding to the manuscript submission entitled "CCL2 enhances macrophage inflammatory responses via miR-9 mediated downregulation of the ERK1/2 phosphatase Dusp6"
- Discipline:
- Science
-
- Creator:
- Ozturk, Dogacan Su
- Description:
- The rapid increases in solar wind dynamic pressure, termed sudden impulses (SIs), compress Earth’s dayside magnetosphere and strongly perturb the coupled Magnetosphere-Ionosphere (M-I) system. The compression of the dayside magnetosphere launches magnetohydrodynamic (MHD) waves, which propagate down to the ionosphere, changing the Auroral Field Aligned Currents (FACs), and into nightside magnetosphere. The global response to the compression front sweeping through the coupled system is not yet fully understood due to the sparseness of the measurements, especially those with the necessary time resolution to resolve the propagating disturbances. That’s why a study including modeling is necessary. On 15 August 2015 at 7.44 UT, Advanced Composition Explorer measured a sudden increase in the solar wind dynamic pressure from 1.11 nPa to 2.55 nPa as shown in Figure-1. We use the magnetospheric spacecraft in the equatorial magnetosphere to identify the signatures of magnetosphere response to this SI event and examine the interaction of the propagating disturbances with the M-I system. With the increased time resolution of Active Magnetosphere and Polar Electrodynamics Response Experiment (AMPERE), the FAC pattern and intensity change due to SI can also be studied in more depth. We further use measurements from ground based magnetometer stations to increase our tracking capability for the disturbances in the ionosphere and to improve our understanding of their propagation characteristics. This is the first step in a comprehensive multi-point observation and a global magnetohydrodynamic simulation based investigation of the response of the coupled M-I system to sudden impulses.
- Citation to related publication:
- Ozturk, Doga & Zou, Shasha & Slavin, James. (2016). The Response of the Coupled Magnetosphere-Ionosphere System to the 15 August 2015 Solar Wind Dynamic Pressure Enhancement. https://www.researchgate.net/publication/300020219
- Discipline:
- Science
-
- Creator:
- Stoev, Stilian and Hu, Weifeng
- Description:
- Many data sets come as point patterns of the form (longitude, latitude, time, magnitude). The examples of data sets in this format includes tornado events, origins/destination of internet flows, earthquakes, terrorist attacks and etc. It is difficult to visualize the data with simple plotting. This research project studies and implements non-parametric kernel smoothing in Python as a way of visualizing the intensity of point patterns in space and time. A two-dimensional grid M with size mx, my is used to store the calculation result for the kernel smoothing of each grid points. The heat-map in Python then uses the grid to plot the resulting images on a map where the resolution is determined by mx and my. The resulting images also depend on a spatial and a temporal smoothing parameters, which control the resolution (smoothness) of the figure. The Python code is applied to visualize over 56,000 tornado landings in the continental U.S. from the period 1950 - 2014. The magnitudes of the tornado are based on Fujita scale.
- Citation to related publication:
- Hu, Weifeng. “Kernel-based Visualization of Point Patterns in Python with Application to Tornado Landing Data.” (2016). At https://www.semanticscholar.org/paper/Kernel-based-Visualization-of-Point-Patterns-in-to-Hu/0de06a6db39da54fe28f8d0cb47c0d3270f2f831
- Discipline:
- Engineering and Science
-
- Creator:
- Heath, Jeffrey and Dicko, Adama
- Description:
- transcription/translation to appear
- Discipline:
- Humanities
-
- Creator:
- Heath, Jeffrey and Dicko, Adama
- Description:
- translation/transcription to appear
- Discipline:
- Humanities
-
- Creator:
- Heath, Jeffrey and Dicko, Adama
- Description:
- transcription/translation to appear.
- Discipline:
- Humanities
-
- Creator:
- Heath, Jeffrey and Dicko, Adama
- Description:
- translation/translation to appear.
- Discipline:
- Humanities
-
- Creator:
- Heath, Jeffrey and Dicko, Adama
- Description:
- transcriptions and translation to appear; second of two parts of this text
- Discipline:
- Humanities
-
- Creator:
- Grosh, Karl and Li, Yizeng
- Description:
- In a sensitive cochlea, the basilar membrane response to transient excitation of any kind--normal acoustic or artificial intracochlear excitation--consists of not only a primary impulse but also a coda of delayed secondary responses with varying amplitudes but similar spectral content around the characteristic frequency of the measurement location. The coda, sometimes referred to as echoes or ringing, has been described as a form of local, short term memory which may influence the ability of the auditory system to detect gaps in an acoustic stimulus such as speech. Depending on the individual cochlea, the temporal gap between the primary impulse and the following coda ranges from once to thrice the group delay of the primary impulse (the group delay of the primary impulse is on the order of a few hundred microseconds). The coda is physiologically vulnerable, disappearing when the cochlea is compromised even slightly. The multicomponent sensitive response is not yet completely understood. We use a physiologically-based, mathematical model to investigate (i) the generation of the primary impulse response and the dependence of the group delay on the various stimulation methods, (ii) the effect of spatial perturbations in the properties of mechanically sensitive ion channels on the generation and separation of delayed secondary responses. The model suggests that the presence of the secondary responses depends on the wavenumber content of a perturbation and the activity level of the cochlea. In addition, the model shows that the varying temporal gaps between adjacent coda seen in experiments depend on the individual profiles of perturbations. Implications for non-invasive cochlear diagnosis are also discussed.
- Citation to related publication:
- Li, Yizeng, and Karl Grosh. “The Coda of the Transient Response in a Sensitive Cochlea: A Computational Modeling Study.” PLOS Computational Biology 12, no. 7 (July 5, 2016): e1005015. https://doi.org/10.1371/journal.pcbi.1005015
- Discipline:
- Engineering and Health Sciences
-
- Creator:
- Atwell, Jon
- Description:
- The data file is json formatted and all fields are named descriptively. The code is written in Python 2.7 and is heavily commented.
- Keyword:
- inequality and coadaptation
- Citation to related publication:
- Atwell J, Savit R (2016) The Emergence of Groups and Inequality through Co-Adaptation. PLoS ONE 11(6): e0158144. https://doi.org/10.1371/journal.pone.0158144
- Discipline:
- Social Sciences and Science
-
- Creator:
- Ottaviani, Jim
- Description:
- This random sample of OA articles comes from Deep Blue <deepblue.lib.umich.edu/documents>, the University of Michigan’s institutional repository service. Each OA article has the following characteristics: Prior to a known date (ranging from 2006 to the 2013) these articles—the final published version—were only available by subscription. After that date, they became freely available via Deep Blue. Meanwhile, other articles from the same journal issue as the now-OA article continued to only be available to subscribers. None of the OA articles were self-selected; authors did not choose to deposit the articles in question in Deep Blue, since we made them open via blanket licensing agreements between the publishers and the library.
- Keyword:
- Open access publishing, Scientific publishing, Citation analysis, and Institutional repositories
- Citation to related publication:
- Ottaviani J (2016) The Post-Embargo Open Access Citation Advantage: It Exists (Probably), It’s Modest (Usually), and the Rich Get Richer (of Course). PLoS ONE 11(8): e0159614. https://doi.org/10.1371/journal.pone.0159614
- Discipline:
- Social Sciences
-
- Creator:
- Wen, Ai, Foxman. Betsy, Srinivasan, Usha , Goldberg, Deborah , Marrs, Carl F , Owen, John, Wing, Deborah A., Misra, Dawn , Cronenwett, Anna , Ponnaluri, Sreelatha, Miles-Jay, Arianna, Bucholz, Brigette, and Abbas, Khadija
- Description:
- This is the bacterial DNA data extracted from the gram stain slides. The targeted bacteria genera and species include: Atopobium spp., bacterial vaginosis-associated bacterium (BVAB) types 1, 2 and 3 in the order Clostridiales, Escherichia coli, Gardnerella vaginalis, Group B Streptococcus, Lactobacillus spp., Mobiluncus spp., Mycoplasma spp., and Ureaplasma spp. We also used a primer set for Lactic Acid Bacteria (LAB) that includes lactic acid producing bacteria of the genera Lactobacillus, Pediococcus, Leuconostoc, and Weissella. We calculated the relative proportion of each bacterial taxon using the bacterial copies measured by each specific bacteria primer divided by the total bacterial copies. The limit of detection was 100 copies and readings lower than the limit were considered negative
- Citation to related publication:
- Wen A, Srinivasan U, Goldberg D, Owen J, Marrs CF, Misra D, Wing DA, Ponnaluri S, Miles-Jay A, Bucholz B, Abbas K, Foxman B. Selected vaginal bacteria and risk of preterm birth: an ecological perspective. J Infect Dis. 2014 Apr 1;209(7):1087-94. https://doi.org/10.1093/infdis/jit632. Epub 2013 Nov 22. PMID: 24273044; PMCID: PMC3952673. and Foxman B, Wen A, Srinivasan U, Goldberg D, Marrs CF, Owen J, Wing DA, Misra D. Mycoplasma, bacterial vaginosis-associated bacteria BVAB3, race, and risk of preterm birth in a high-risk cohort. Am J Obstet Gynecol. 2014 Mar;210(3):226.e1-7. https://doi.org/10.1016/j.ajog.2013.10.003. Epub 2013 Oct 4. PMID: 24096128; PMCID: PMC3943817.
- Discipline:
- Health Sciences
-
- Creator:
- Meurer, William J., Meka, Arjun, and Porath, Jon
- Description:
- Introduction: Diagnostic testing is common in the emergency department. The value of some testing is questionable. The purpose of this study was to assess how varying levels of benefit, risk, and costs influenced an individual’s desire to have diagnostic testing. Methods: A survey through Amazon Mechanical Turk presented hypothetical clinical situations: low risk chest pain and minor traumatic brain injury. Each scenario included three given variables (benefit, risk, and cost), that was independently randomly varied over four possible values (0.1%, 1%, 5%, 10% for benefit and risk and $0, $100, $500, and $1000 for the individual’s personal cost for receiving the test). Benefit was defined as the probability of finding the target disease (traumatic intracranial hemorrhage or acute coronary syndrome). Results: A total of 1000 unique respondents completed the survey. Increasing benefit from 0.1% to 10%, the percent of respondents who accepted a diagnostic test went from 28.4% to 53.1%. [OR: 3.42 (2.57-4.54)] As risk increased from 0.1% to 10%, this number decreased from 52.5% to 28.5%. [OR: 0.33 (0.25-0.44)] Increasing cost from $0 to $1000 had the greatest change of those accepting the test from 61.1% to 21.4%, respectively. [OR: 0.15 (0.11-0.2)] Conclusions: The desire for testing was strongly sensitive to the benefits, risks and costs. Many participants wanted a test when there was no added cost, regardless of benefit or risk levels, but far fewer elected to receive the test as cost increased incrementally. This suggests that out of pocket costs may deter patients from undergoing diagnostic testing with low potential benefit.
- Discipline:
- Health Sciences
-
- Creator:
- Carson, William F. IV
- Description:
- Data files pertaining to the manuscript entitled: "THE STAT4/MLL1 EPIGENETIC AXIS REGULATES THE ANTIMICROBIAL FUNCTIONS OF MURINE MACROPHAGES"
- Discipline:
- Health Sciences
-
- Creator:
- Carson, William F., IV
- Description:
- Transcriptional accessibility of chromatin is central to guiding CD4+ T cell function through regulation of lineage specific gene expression. Myst1 is a histone acetyltransferase responsible for acetylation of the protein tail of histone 4 at lysine residue 16 (H416ac), resulting in increased transcriptional accessibility and activation of gene transcription. Previous studies have described a role for Myst1 in governing lymphocyte development in the thymus, however the role of Myst1 and H4K16ac in guiding activation of peripheral CD4+ T cells has not been studied. Activation of human and murine CD4+ T cells resulted in upregulation of Myst1 expression, and deletion of Myst1 resulted in changes in proliferative responses to both polyclonal stimulus and exogenous cytokines. Myst1-deficient T cells also exhibited modulations in lineage commitment, with decreased function in TH1/TH2 skewing conditions and increased function in response to TH17-promoting conditions. Regulation of Myst1 function in CD4+ T cells appears governed at least in part by STAT5, as Myst1 expression is regulated by STAT5 expression and DNA binding, and modulations in H4K16ac in Myst1-deficient CD4+ T cells is observable at sites in the promoter regions of lineage specific genes following skewing to the TH1 or TH2 lineage in vitro. Taken together, these results indicate an important role for the STAT5-Myst1 epigenetic axis in governing the activation and effector function of CD4+ T cells.
- Discipline:
- Science