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- Creator:
- Derstine, Brian A., Holcombe, Sven A., Ross, Brian E., Sullivan, June A., Wang, Stewart C., and Su, Grace L.
- Description:
- Sarcopenia is the age-related loss of skeletal muscle mass and function. Computed tomography (CT) assessments of sarcopenia utilize measurements of skeletal muscle cross-sectional area (SMA), radiation attenuation (SMRA), intramuscular adipose tissue (IMAT), and skeletal muscle gauge (SMG). Unadjusted SMA is strongly correlated with both height and body mass index (BMI); therefore, SMA must be adjusted for body size to assess sarcopenic low muscle mass fairly in individuals of different heights and BMI. SMA/height (rather than SMA/height^2) provides optimal height adjustment for skeletal muscle index (SMI), and vertebra-specific relative muscle index (RMI) equations optimally adjust for both height and BMI. Since L3 measurement is not available in all CT scans, sarcopenic low muscle mass may be assessed using other levels. Both a mid-vertebral slice and an inferior slice have been used to define `L3 SMA', but the effect of vertebral slice location on SMA measurements is unexplored. Healthy reference values for skeletal muscle measures at mid- and inferior vertebra slices between T10 and L5, have not yet been reported.
- Keyword:
- sarcopenia, skeletal muscle, reference population, Morphomics, Analytic Morphomics, and body composition
- Citation to related publication:
- Derstine, B.A., Holcombe, S.A., Wang, N.C. et al. Relative muscle indices and healthy reference values for sarcopenia assessment using T10 through L5 computed tomography skeletal muscle area. Scientific Reports 14, 21799 (2024). https://doi.org/10.1038/s41598-024-71613-x
- Discipline:
- Health Sciences
-
- Creator:
- Kimbrough, Erik, Murray, Jennifer, Sarmiento, Olga, Krupka, Erin, Ramalingam, Abhijit , Kee, Frank, Kumar, Rajnish, Sánchez-Franco, Sharon , and Hunter, Ruth
- Description:
- THE DATA: Unfortunately, we are unable to share our data for this project. Since we were working with a vulnerable population (children), we were asked by Queens University Belfast’s IRB-equivalent to include language in the consent documents indicating that the data would not be shared outside of the research team. Thus, the datasets generated during and/or analyzed during the current study are not publicly available as participants were informed that no-one outside of the research team would have access to the research data when they signed their consent forms. Thus, we provide Stata, R and Mplus scripts used to generate all tables and figures reported in the paper. Since we cannot share the raw study data, most of these files cannot be run, but in the interest of transparency we include the scripts so that our code can be checked. Since a major portion of the paper is the LTA modeling, we took an additional step there and generated simulated data that allows the R+Mplus scripts to be run. These runnable scripts and the simulated data are contained in the subfolder LTA_code_EXEC. For further information about the study datasets, please contact the authors (Emails: Jennifer.Murray@qub.ac.uk; ruth.hunter@qub.ac.uk)
- Keyword:
- norms heterogeneity, experimental economics, and RCT
- Citation to related publication:
- Kimbrough, E., Krupka, E., Kumar, R., Murray, J., and Ramalingam, A. (conditional accept). On the Stability of Norms and Norm-Following Propensity: A Cross Cultural Panel Study with Adolescents. Experimental Economics
- Discipline:
- Health Sciences and Social Sciences
-
- Creator:
- Bitzer, Markus
- Description:
- Kidney tissue was analyzed for spatial localization of features and associations with clinical parameters.
- Keyword:
- Kidney, Pathology, Human, and Image analysis
- Discipline:
- Health Sciences
-
- Creator:
- Herzog, Joshua M, Verkade, Angela, and Sick, Volker
- Description:
- Data deposited here includes 60 image sets (30 individual participants, and 2 eyes per individual) consisting of raw fluorescence images, diffuse reflection images using ambient lighting, images used for correction, and calibration, and metadata. Images are split into two wavelength bands as described in the methodology. Raw images are stored in Hierarchical Data Format 5 (HDF5) file nodes (one file per eye) and each image node contains a tag for frame rate, exposure duration, and timestamp (stored in ImageData.zip). Summary statistics including demographic data, participant-reported diseases (e.g., diabetes, keratoconus), and pupil size are also stored in a text-based comma-separated table and as an Excel spreadsheet. Finally, 2-channel pseudocolor images and ratiometric grayscale images combining the two fully-processed image bands are stored as portable network graphics (PNG) files (stored in PseudocolorImages.zip).
- Keyword:
- Fluorescence, Imaging, Ocular lens, Corneal disease, Cataract, and Diabetes
- Citation to related publication:
- Herzog, Joshua M., Verkade, Angela, and Sick, Volker. "Corneal shadowgraphy: a simple, low-cost, rapid, and quantitative tool with potential clinical utility." Manuscript in review. 2024. and Herzog, Joshua M., Verkade, Angela, and Sick, Volker. "Quantitative and rapid in vivo imaging of human lenticular fluorescence." Manuscript in review. 2024.
- Discipline:
- Health Sciences and Engineering
-
- Creator:
- A. Tapaswi, N. Cemalovic, K. Polemi, J. Sexton, and J. Colacino
- Description:
- MCF10A non-tumorigenic breast cells were dosed with environmental toxicants and stained with multiple cellular stains to study morphological perturbations. Following up on feature results, MCF10A cells were stained with an anti-beta catenin antibody to study beta catenin nuclear translocation. Cell profiler software was used to measure and export per cell data .CSV formats to be further analyze din BMDExpress2 and R studio
- Keyword:
- Breast cancer , Cell Painting, Chemical exposure, Benchmark dose, and Cell Profiler
- Discipline:
- Health Sciences
-
- Creator:
- Fahim, Abigail T
- Description:
- The purpose of this research is to compare levels of unprenylated Rab proteins in CHM-/- iPSC-RPE cells with and without compactin. Compactin is a statin that inhibits prenyl synthesis and thereby reduces prenylation overall and has an unbiased inhibitory effect on all protein prenylation. So we expect that for Rabs that are already poorly prenylated at baseline in choroideremia RPE cells, compactin will have minimal effect. However, for Rabs that are efficiently prenylated at baseline, compactin should have a much greater effect. And then we used tandem mass tag spectrometry to compare the ratio of each unprenylated Rab in compactin-treated choroideremia cells vs untreated choroideremia cells. In the spreadsheet, "F8" refers to the CHM-/- iPSC-RPE cells and "WT" refers to the isogenic control iPSC-RPE cells. In the "Proteins only" tab, column M shows the ratio of each protein in "DMSO" (untreated) choroideremia cells compared to Compactin-treated choroideremia cells. Compactin-treated control cells are also included in other columns. Untreated control cells could not be used because prenylation is so efficient in these cells, there is almost no material available after doing the in vitro prenylation assay (i.e. almost no unprenylated proteins to biotinylate). The column descriptions can be found in the sheet titled "Explanations." In addition, AAs= number of amino acids in the protein, MW= molecular weight of the protein, and pI= isoelectric point. The software is set to report abundance values only when certain criteria are met (S/N of 6, unique peptide etc). A value is NOT reported when the data for a protein fall below these criteria and the cell is instead left blank.
- Keyword:
- choroideremia, retinal pigment epithelium, prenylation, and Rab protein
- Citation to related publication:
- Raeker, M.O., Perera, N.D., Karoukis, A.J., Chen, L., Feathers, K.L., Ali, R.R., Thompson, D.A., Fahim, A.T. Reduced retinal pigment epithelial autophagy due to loss of Rab12 prenylation in a human iPSC-RPE model of choroideremia. Cells, manuscript accepted, in press.
- Discipline:
- Health Sciences and Science
-
- Creator:
- Pedde, Meredith
- Description:
- In this study, we took advantage of the randomized allocation of the US EPA's funding for school bus replacements and retrofits to causally assess the impacts of upgrading buses on students' educational performance through the EPA’s national School Bus Rebate Program. Specifically, we used classical intent-to-treat analyses for randomized controlled trials to compare the change in school district level reading and language arts and math standardized test scores after vs before the 2012 through 2016 lotteries by funding selection status . We used overall district average standardized test scores since rates were not available for only school-bus riders.
- Keyword:
- School Bus Emissions, Diesel Air Pollution, and Student standardized testing
- Citation to related publication:
- Pedde, M., Szpiro, A., Hirth, R., Adar, S. School Bus Rebate Program and Student Educational Performance Test Scores. JAMA Network Open (2024). https://doi.org/10.1001/jamanetworkopen.2024.3121
- Discipline:
- Health Sciences
-
- Creator:
- Bautista-Arredondo, Luis F., Muñoz-Rocha, T. Verenice, Figueroa, José L., Téllez-Rojo, Martha M., Torres-Olascoaga, Libni A., Cantoral, Alejandra, Arboleda-Merino, Laura C., Leung, Cindy, Peterson, Karen E., and Lamadrid-Figueroa, Héctor
- Description:
- Data was collected from participants of the Early Life Exposures in Mexico to ENvironmental Toxicants (ELEMENT) study, which consists of three sequentially-enrolled birth cohorts of pregnant women. Research protocols of this study were approved by the Institutional Review Board at University of Michigan and the Mexico National Institute of Public Health. We obtained informed consent from study participants prior to enrollment.
- Keyword:
- Food Insecurity, COVID-19 Pandemic, Mexico, Cohort
- Citation to related publication:
- Bautista-Arredondo LF, Verenice Muñoz-Rocha T, Figueroa JL, Téllez-Rojo MM, Torres-Olascoaga LA, Cantoral A, Arboleda-Merino L, Leung L, Peterson KE, and Lamadrid-Figueroa H. A surge in food insecurity during the COVID-19 pandemic in a cohort in Mexico City. 2022. Article in process of publication.
- Discipline:
- Health Sciences
-
- Creator:
- Dariya, Malyarenko, Tariq, Humera, Kushwaha, Aman, Mourad, Rami, Heist, Kevin, Chenevert, Thomas L, Ross, Brian D, Chen, Heang-Ping, and Hadjiiski, Lubomir
- Description:
- The 3D GRE MRI data for murine model of myelofbifrosis with expert segmentations of mouse tibia was used to train Attention UNET model to automate bone marrow segmentation for measurements of imaging biomarkers. This dataset consists of three archives: (1) containing the source MRI images in Meta-image-header (MHD) format with resulting segmentation labels by two experts and four UNET models with different training scenarios; (2) corresponding training models; and (3) deep-learning (DL)-based segmentation tools for application to future murine tibia MRI data. and The MHD images are an ITK compatible format that can be viewed in standard image viewer, like 3D Slicer. The image archive is structured with a directory tree that contains \"mouseID"\"scan-date"\"segmentaion-scenario"\. The "training model" archive containes DL-model labeled by the data subset, and "deployment" archive containes the DL-segmentation software.
- Keyword:
- deep-learning segmentation, preclinical MRI, murine tibia, and mouse model of myelofibrosis
- Citation to related publication:
- Kushwaha A, Mourad RF, Heist K, Tariq H, Chan HP, Ross BD, Chenevert TL, Malyarenko D, Hadjiiski LM. Improved Repeatability of Mouse Tibia Volume Segmentation in Murine Myelofibrosis Model Using Deep Learning. Tomography. 2023 Mar 7;9(2):589-602. doi: 10.3390/tomography9020048. PMID: 36961007; PMCID: PMC10037585. and https://github.com/dumichgh/MFJK1_Segmentation_MHDs
- Discipline:
- Health Sciences
-
- Creator:
- Malyarenko, Dariya, Chenevert, Thomas L, Heist, Kevin, Bonham, Christopher, and Ross, Brian
- Description:
- The imaging data was used to measure repeatability and temporal trends of quantitative imaging biomarkers of myelofibrosis in bone marrow based on apparent diffusion coefficient, fat fraction and magnetization transfer ratio. The dataset consists of time series of the MRI Meta-image-header (MHD) images of wild type and diseased mice combined by the imaging time point. The MHD images are an ITK compatible format that can be viewed in standard image viewer, like 3D Slicer. Each time point image archive is structured with a directory tree that contains ./././"mouseID"/"scan-date"/"acquisition type"/
- Keyword:
- murine tibia MRI, bone marrow imaging, apparent diffusion coefficient (ADC), proton density fat fraction (PDFF), magnetization transfer ratio (MTR), and pre-clinical model of myelofibrosis
- Citation to related publication:
- Ross BD, Malyarenko D, Heist K, Amouzandeh G, Jang Y, Bonham CA, Amirfazli C, Luker GD, Chenevert TL. Repeatability of Quantitative Magnetic Resonance Imaging Biomarkers in the Tibia Bone Marrow of a Murine Myelofibrosis Model. Tomography. 2023 Feb 28;9(2):552-566. doi: 10.3390/tomography9020045. PMID: 36961004; PMCID: PMC10037563.
- Discipline:
- Health Sciences