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- Creator:
- Potter, Natalie S., McLean, Alan , Bornowski, Evan C., Hopkins, Thomas, Luo, Jingyi, Wolfe, John P., Qian, Wei, and Kopelman, Raoul
- Description:
- Research data supporting, 'Flexible Synthesis Scheme and Application of AuNP Surface-Conjugatable Meta-Iodobenzylguanidine Derivatives for Enhanced Cellular Internalization', 10.1021/acsmaterialslett.3c00781, AuNP = Au nanoparticle. In 10.1021/acsmaterialslett.3c00781, we report the synthesis and application of two metaiodobenzylguanidine (MIBG) derivatives decorated on the surface of AuNPs at high molar ratios; greatly enhanced cellular uptake is observed across neuroblastoma (NB), HeLa, and HEK cell lines. This dataset consists of synthetic NMR and mass spec data for the small molecules and their intermediates, dark-field microscopy data, inductively-coupled plasma mass spectrometry data, and raw data for characterizing the AuNPs (TEM, DLS, zeta potential).
- Keyword:
- chemistry, MIBG, nanoparticle, AuNP, synthesis, ICP-MS
- Citation to related publication:
- Flexible Synthesis Scheme and Application of AuNP Surface-Conjugatable Metaiodobenzylguanidine Derivatives for Enhanced Cellular Internalization Natalie S. Potter, Alan McLean, Evan C. Bornowski, Thomas Hopkins, Jingyi Luo, John P. Wolfe, Wei Qian, and Raoul Kopelman ACS Materials Letters Article ASAP DOI: 10.1021/acsmaterialslett.3c00781
- Discipline:
- Science
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- Creator:
- Folz, Jeff
- Description:
- Data consists largely of UV-VIs spectra, both raw and analyzed, that were used to calibrate the relevant sensor. A more detailed description of individual files' contents can be found in the ReadMe word document.
- Discipline:
- Science
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- Creator:
- Hou, Qian, Chatterjee, Surajit, Lund, Paul E., Suddala, Krishna C., and Walter, Nils G.
- Description:
- Bacteria live in a broad range of environmental temperatures that require adaptations of their RNA sequences to maintain function. Riboswitches are regulatory RNAs that change conformation upon binding of typical metabolite ligands to control bacterial gene expression. The paradigmatic small class-I preQ1 riboswitches from the mesophile Bacillus subtilis (Bsu) and the thermophile Thermoanaerobacter tengcongensis (Tte) adopt similar pseudoknot structures when bound to preQ1. Here, we use single-molecule detected chemical denaturation by urea to compare the thermodynamic and kinetic folding properties of the two riboswitches, and the urea-countering effects of trimethylamine N-oxide (TMAO). This data includes the experimental findings and associated analyses detailed in the research article titled "Single-molecule FRET observes opposing effects of urea and TMAO on structurally similar meso- and thermophilic riboswitch RNAs". The data consists of multiple zip files, each representing an experiment that corresponds to the key results in the publication. Each experiment includes movies, qualifying smFRET trajectories, and analysis files related to various conditions within that experimental group.
- Keyword:
- Riboswitch, Single molecule FRET, RNA folding, UV-melting, Osmolyte, Urea, and Trimethylamine N-oxide
- Citation to related publication:
- https://doi.org/10.1093/nar/gkad866
- Discipline:
- Science
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- Creator:
- Kort, Eric A., Plant, Genevieve, Brandt, Adam R., Chen, Yuanlei, Gorchov Negron, Alan M., and Smith, Mackenzie L.
- Description:
- As part of the Flaring & Fossil Fuels: Uncovering Emissions & Losses (F3UEL) project, in 2022 the aircraft measurement platform sampled offshore oil & gas facilities in the US Gulf of Mexico to quantify facility-level emissions using the approach detailed in Conley et al. (2017). Vertical profiles were conducted on each flight to capture the vertical structure and mixing depths of the atmosphere. The data file contains all merged flight data from each flight day. Reference: Conley, S., Faloona, I., Mehrotra, S., Suard, M., Lenschow, D. H., Sweeney, C., Herndon, S., Schwietzke, S., Pétron, G., Pifer, J., Kort, E. A., and Schnell, R.: Application of Gauss’s theorem to quantify localized surface emissions from airborne measurements of wind and trace gases, Atmos. Meas. Tech., 10, 3345 – 3358, 2017.
- Keyword:
- Offshore Oil & Gas, Methane, Nitrogen Oxides, and Gulf of Mexico
- Discipline:
- Science
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- Creator:
- Ponder, Brandon M., Ridley, Aaron J., Goel, Ankit, and Bernstein, Dennis S.
- Description:
- This research was completed to statistically validate that a data-model refinement technique could integrate real measurements to remove bias from physics-based models via changing the forcing parameters such as the thermal conductivity coefficients.
- Keyword:
- Thermosphere, GITM, CHAMP, GRACE, MSIS, Upper Atmosphere Modeling, and Data Assimilation
- Citation to related publication:
- Ponder, B. M., Ridley, A. J., Goel, A., & Bernstein, D. S. (2023). Improving forecasting ability of GITM using data-driven model refinement. Space Weather, 21, e2022SW003290. https://doi.org/10.1029/2022SW003290
- Discipline:
- Engineering and Science
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- Creator:
- McCuen, Brett A.
- Description:
- We present a comprehensive statistical analysis of high-frequency transient-large-amplitude (TLA) magnetic perturbation events that occurred at 12 high-latitude ground magnetometer stations throughout solar cycle 24 from 2009 to 2019. TLA signatures are defined as one or more second-timescale dB/dt interval with magnitude ≥ 6 nT/s within an hour event window. This study characterizes high-frequency TLA events based on their spatial and temporal behavior as well as relation to auroral substorms, geomagnetic storm phases and nighttime geomagnetic disturbance events events (GMD). We show that TLA events occur primarily at nighttime and solely in the high-latitude region above 60 degrees geomagnetic latitude. The largest TLA events occurred more often in the declining phase of the solar cycle when solar wind velocity was higher and ring current activity was lower, suggesting association to high-speed flows caused by coronal holes and subsequent corotating interaction regions reaching Earth. TLA perturbations often occurred preceding or within the most extreme nighttime geomagnetic disturbance (GMD) events with 5-10 minute timescales, but the TLA intervals were often even more localized than the ~300 km effective radius of GMDs: occurring at only some of the stations at which GMDs occurred. We show that TLA-related GMD events can result from dipolarization fronts in the magnetotail and fast flows toward Earth and are closely temporally associated to poleward boundary intensifications (PBI) and auroral streamers. The highly localized behavior and connection to the most extreme GMD events suggests that TLA intervals are a ground manifestation of the features within rapid and complex ionospheric structures that can drive GICs.
- Keyword:
- geomagnetic field, high frequency, space weather, transient-large-amplitude, TLA, high frequency dB/dt, dB/dt search algorithm
- Citation to related publication:
- McCuen, B. A., Moldwin, M. B., Engebretson, M. J., Weygand, J. G., Nishimura, Y. (2023). A Statistical Analysis of High-frequency Transient-Large-Amplitude Geomagnetic Disturbance. [To be submitted to] Journal of Geophysical Research: Space Physics
- Discipline:
- Science
-
- Creator:
- University of Michigan Museum of Paleontology and CTEES
- Description:
- Reconstructed CT slices for tooth in bone fragment of Colognathus obscurus (University of Michigan Museum of Paleontology catalog number UMMP 7506) as a series of TIFF images. Raw projections are not included in this dataset. The reconstructed slice data from the scan are offered here as a series of unsigned 16-bit integer TIFF images. The upper left corner of the first image (*_0000.tif) is the XYZ origin.
- Keyword:
- Paleontology, Fossil, CT, Reptile, UMMP, University of Michigan Museum of Paleontology, Triassic, and bf7ead64-3fff-a3f2-6b15-d04548dae2da
- Discipline:
- Science
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- Creator:
- Umaña, Maria, Swenson, Nathan G, and Arellano, Gabriel
- Description:
- Identifying the functional traits that enable recovery after extreme events is necessary for assessing forest persistence and functioning, yet this is a difficult task because the traits mediating the responses to disturbance may vary depending on the disturbance type and over time. This study investigates the effects of traits on tree growth –for short and longer terms– in response to two vastly different extreme climatic events, droughts, and hurricanes, in a Puerto Rican forest.
- Keyword:
- Tropical tree, relative growth rates , and Puerto Rico
- Citation to related publication:
- Umaña, M. N. In review. The interplay of drought and hurricanes on tree recovery: insights from dynamic and weak functional responses. Forthcoming and Umana, M. (2023). Functional trait data across an elevational gradient of six tree species in El Yunque National Park, Puerto Rico in 2015 [Data set], University of Michigan - Deep Blue Data. https://doi.org/10.7302/7962-4t98
- Discipline:
- Science
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- Creator:
- Ludlow, Andrew and Kim, Jeongjin
- Description:
- Part of the regulation of telomerase activity includes the alternative splicing (AS) of the catalytic subunit telomerase reverse transcriptase (TERT). Although a therapeutic window for telomerase/TERT inhibition exists between cancer cells and somatic cells, stem cells express TERT and rely on telomerase activity for physiological replacement of cells. Therefore, identifying differences in TERT regulation between stem cells and cancer cells is essential for developing telomerase inhibition-based cancer therapies that reduce damage to stem cells. In this study, we measured TERT splice variant expression and telomerase activity in induced pluripotent stem cells (iPSCs), neural progenitor cells (NPCs), and non-small cell lung cancer cells (NSCLC, Calu-6 cells). We observed that a NOVA1-PTBP1-PTBP2 axis regulates TERT alternative splicing (AS) in iPSCs and their differentiation into NPCs. We also found that splice-switching of TERT, which regulates telomerase activity, is induced by different cell densities in stem cells but not cancer cells. Lastly, we identified cell type-specific splicing factors that regulate TERT AS. Overall, our findings represent an important step forward in understanding the regulation of TERT AS in stem cells and cancer cells. These data and subsequent studies may reveal a splicing factor(s) or their binding site(s) that could be targeted with small molecule drugs or antisense oligonucleotides, respectively, to reduce telomerase activity in cancer cells and promote durable cancer remissions.
- Keyword:
- Telomere, telomerase, TERT, alternative RNA splicing
- Citation to related publication:
- Dynamics of TERT Regulation via Alternative Splicing in Stem Cells and Cancer Cells. Accepted in Plos One
- Discipline:
- Science
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- Creator:
- Ye, Zhengwei and Mi, Zetian
- Description:
- Generation of C2+ compounds using sunlight, carbon dioxide, and water provides a promising path for carbon neutrality. The exploration of a catalyst to break the bottleneck of C-C coupling, for constructing a rational artificial photosynthesis integrated device, is at the core. Herein, based on operando spectroscopy measurements, theoretical calculations, and feedstock experiments, it is discovered that gold, in conjunction with iridium, can catalyze the reduction of CO2, achieving C-C coupling by insertion of CO2 into -CH3. Owing to a combination of optoelectronic and catalytic properties, the assembly of AuIr with InGaN nanowires on silicon (AuIr@InGaN NWs/Si) enables the achievement of a C2H6 activity of 58.8 mmol‧g-1‧h-1 with a turnover number of 54,595 over 60 hours. A light-to-fuels efficiency of ~0.59% for solar fuels production from CO2 and H2O is achieved without any other energy inputs. This work provides a carbon-negative path for producing higher order C compounds.
- Keyword:
- Carbon dioxide reduction and Photocatalysis
- Discipline:
- Science