Single molecule data and analysis code for Figure4 in the paper titled: "A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower".
Follow the readme file for deiails.
This research was completed to statistically validate that a data-model refinement technique could integrate real measurements to remove bias from physics-based models via changing the forcing parameters such as the thermal conductivity coefficients.
Ponder, B. M., Ridley, A. J., Goel, A., & Bernstein, D. S. (2023). Improving forecasting ability of GITM using data-driven model refinement. Space Weather, 21, e2022SW003290. https://doi.org/10.1029/2022SW003290
This is the model and observational data referenced in our manuscript entitled “surface and sub-subsurface internal gravity wave kinetic energy spectra from global ocean models and observations.” The model data for the 7 regions from the two global simulations (HYCOM and MITgcm) can be found here.
We present a comprehensive statistical analysis of high-frequency transient-large-amplitude
(TLA) magnetic perturbation events that occurred at 12 high-latitude ground magnetometer
stations throughout solar cycle 24 from 2009 to 2019. TLA signatures are defined as one or
more second-timescale dB/dt interval with magnitude ≥ 6 nT/s within
an hour event window. This study characterizes high-frequency TLA events based on their spatial
and temporal behavior as well as relation to auroral substorms, geomagnetic storm phases and
nighttime geomagnetic disturbance events events (GMD). We show that TLA events occur primarily
at nighttime and solely in the high-latitude region above 60 degrees geomagnetic latitude. The
largest TLA events occurred more often in the declining phase of the solar cycle when solar
wind velocity was higher and ring current activity was lower, suggesting association to
high-speed flows caused by coronal holes and subsequent corotating interaction regions reaching
Earth. TLA perturbations often occurred preceding or within the most extreme nighttime
geomagnetic disturbance (GMD) events with 5-10 minute timescales, but the TLA intervals were
often even more localized than the ~300 km effective radius of GMDs:
occurring at only some of the stations at which GMDs occurred. We show that TLA-related GMD
events can result from dipolarization fronts in the magnetotail and fast flows toward Earth
and are closely temporally associated to poleward boundary intensifications (PBI) and auroral
streamers. The highly localized behavior and connection to the most extreme GMD events suggests
that TLA intervals are a ground manifestation of the features within rapid and complex
ionospheric structures that can drive GICs.
McCuen, B. A., Moldwin, M. B., Engebretson, M. J., Weygand, J. G., Nishimura, Y. (2023). A Statistical Analysis of High-frequency Transient-Large-Amplitude Geomagnetic Disturbance. [To be submitted to] Journal of Geophysical Research: Space Physics
Reconstructed CT slices for tooth in bone fragment of Colognathus obscurus (University of Michigan Museum of Paleontology catalog number UMMP 7506) as a series of TIFF images. Raw projections are not included in this dataset. The reconstructed slice data from the scan are offered here as a series of unsigned 16-bit integer TIFF images. The upper left corner of the first image (*_0000.tif) is the XYZ origin.
This is part of the simulation set of geomagnetic storms from 2010 to 2019. The Space Weather Modeling Framework (SWMF) with the configuration of SWPC v2 was used. The output files can be read by the visualization scripts included in the SWMF or the SpacePy Python package.
Identifying the functional traits that enable recovery after extreme events is necessary for assessing forest persistence and functioning, yet this is a difficult task because the traits mediating the responses to disturbance may vary depending on the disturbance type and over time. This study investigates the effects of traits on tree growth –for short and longer terms– in response to two vastly different extreme climatic events, droughts, and hurricanes, in a Puerto Rican forest.
Umaña, M. N. In review. The interplay of drought and hurricanes on tree recovery: insights from dynamic and weak functional responses. Forthcoming and Umana, M. (2023). Functional trait data across an elevational gradient of six tree species in El Yunque National Park, Puerto Rico in 2015 [Data set], University of Michigan - Deep Blue Data. https://doi.org/10.7302/7962-4t98
Part of the regulation of telomerase activity includes the alternative splicing (AS) of the catalytic subunit telomerase reverse transcriptase (TERT). Although a therapeutic window for telomerase/TERT inhibition exists between cancer cells and somatic cells, stem cells express TERT and rely on telomerase activity for physiological replacement of cells. Therefore, identifying differences in TERT regulation between stem cells and cancer cells is essential for developing telomerase inhibition-based cancer therapies that reduce damage to stem cells. In this study, we measured TERT splice variant expression and telomerase activity in induced pluripotent stem cells (iPSCs), neural progenitor cells (NPCs), and non-small cell lung cancer cells (NSCLC, Calu-6 cells). We observed that a NOVA1-PTBP1-PTBP2 axis regulates TERT alternative splicing (AS) in iPSCs and their differentiation into NPCs. We also found that splice-switching of TERT, which regulates telomerase activity, is induced by different cell densities in stem cells but not cancer cells. Lastly, we identified cell type-specific splicing factors that regulate TERT AS. Overall, our findings represent an important step forward in understanding the regulation of TERT AS in stem cells and cancer cells. These data and subsequent studies may reveal a splicing factor(s) or their binding site(s) that could be targeted with small molecule drugs or antisense oligonucleotides, respectively, to reduce telomerase activity in cancer cells and promote durable cancer remissions.
Generation of C2+ compounds using sunlight, carbon dioxide, and water provides a promising path for carbon neutrality. The exploration of a catalyst to break the bottleneck of C-C coupling, for constructing a rational artificial photosynthesis integrated device, is at the core. Herein, based on operando spectroscopy measurements, theoretical calculations, and feedstock experiments, it is discovered that gold, in conjunction with iridium, can catalyze the reduction of CO2, achieving C-C coupling by insertion of CO2 into -CH3. Owing to a combination of optoelectronic and catalytic properties, the assembly of AuIr with InGaN nanowires on silicon (AuIr@InGaN NWs/Si) enables the achievement of a C2H6 activity of 58.8 mmol‧g-1‧h-1 with a turnover number of 54,595 over 60 hours. A light-to-fuels efficiency of ~0.59% for solar fuels production from CO2 and H2O is achieved without any other energy inputs. This work provides a carbon-negative path for producing higher order C compounds.
This dataset contains the results of a survey of mouse handling methods by personnel working with laboratory mice. The survey included questions about preferred handling methods, barriers to use of refined handling methods, and a knowledge quiz about refined mouse handling. Data was collected via Qualtrics survey as described in the methodology section. This dataset is associated with the following publication, accepted by PLOS One:
PONE-D-23-01633R1
Title: Using refined methods to pick up mice: A survey benchmarking prevalence & beliefs about tunnel and cup handling
Authors: Lauren Young, Donna Goldsteen, Elizabeth A. Nunamaker, Mark J. Prescott, Penny Reynolds, Sally Thompson-Iritani, Sarah E. Thurston, Tara L. Martin, Megan R. LaFollette
Young LR, Goldsteen D, Nunamaker EA, Prescott MJ, Reynolds P, Thompson-Iritani S, Thurston SE, Martin TL, LaFollette MR. Using refined methods to pick up mice: A survey benchmarking prevalence & beliefs about tunnel and cup handling. PLOS ONE. 2023. In Press.