Index Catalog // Deep Blue Data

Action current data for investigating the development and organization of GnRH neuron activity in mice.

Creator:: Dulka, Eden A
Description:: This data is a subset of that originally produced as part of an effort to characterize GnRH neuron activity during prepubertal development in control and PNA mice and investigate the potential influences of sex and PNA treatment on this process (1). It was later used in (2) to further investigate the firing patterns of GnRH neurons in these categories of mice and determine how these patterns might differ based on age and treatment condition. The data files can be opened and examined using Wavemetric's Igor Pro software. Code used to further examine and visualize the data can be found at https://gitlab.com/um-mip/mc-project-code. This research was supported by National Institute of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development R01 HD34860 and P50 HD28934. (1) Dulka EA, Moenter SM. Prepubertal development of gonadotropin-releasing hormone (GnRH) neuron activity is altered by sex, age and prenatal androgen exposure. Endocrinology 2017; 158:3941-3953 (2) Penix JJ, DeFazio RA, Dulka EA, Schnell S, Moenter SM. Firing patterns of gonadotropin-releasing hormone (GnRH) neurons are sculpted by their biology. Pending.
Keyword:: action potential, Monte Carlo, polycystic ovary syndrome, puberty, and androgen
Citation to related publication:: Dulka EA, Moenter SM. Prepubertal development of gonadotropin-releasing hormone neuron activity is altered by sex, age and prenatal androgen exposure. Endocrinology 2017; 158:3943-3953. https://dx.doi.org/10.1210%2Fen.2017-00768 and Penix JJ, DeFazio RA, Dulka EA, Schnell S, Moenter SM. Firing patterns of gonadotropin-releasing hormone (GnRH) neurons are sculpted by their biology. Pending.
Discipline:: Health Sciences

Analyzing Reviewer Responses to Systematic Review Search Methodology through Open Peer Review

Creator:: Townsend, Whitney A, MacEachern, Mark P, and Song, Jean
Description:: We conducted a search through BioMed Central's 54 medicine and public health journals that provide OPR documentation in order to identify systematic review papers published in 2017. For each article we determined if OPR data, reviewer and author comments, were accessible. If so, we assessed the search methodology and reporting quality of the search process with a grading rubric based on PRISMA and PRESS standards, and then mined peer reviewer comments for references to the search methodology.
Keyword:: Systematic Reviews, Peer Review, Open Peer Review, Methodology, Research Methods, and Reporting
Discipline:: Health Sciences

Lu-177 DOTATATE Anonymized Patient Datasets: Lu-177 SPECT Time Integrated Activity Maps

Creator:: Dewaraja, Yuni K and Van, Benjamin J
Description:: This publication contains anonymized time integrated activity maps for two patients. SPECT/CT scans were taken at 4 different time points in the week following a therapeutic dose of Lu-177 DOTATATE and combined into a single activity map for each patient. All images are in DICOM format.
Keyword:: Lu-177, Dosimetry, Radionuclide, SPECT, and CT
Discipline:: Health Sciences

Lu-177 DOTATATE Anonymized Patient Datasets: Pre-therapy Diagnostic Images

Creator:: Dewaraja, Yuni K and Van, Benjamin J
Description:: This publication contains anonymized diagnostic imaging scans of two patients. The images provided are pre-therapy scans used by clinicians for diagnosis and for selecting patients for treatment with Lu-177 DOTATATE. Multiple imaging modalities are present including diagnostic CT, MRI, and Ga68 PET, depending on the selected patient. All images are in DICOM format.
Keyword:: Lu-177, Lutathera, Dosimetry, Radionuclide, CT, MRI, and PET
Discipline:: Health Sciences

Literature search files for Firearm violence among LGBTQ+ communities: A scoping review and future directions

Creator:: Saylor, Kate M., King, Wesley M., and Gamarel, Kristi E.
Description:: The search data supports a literature review project on Firearm violence among LGBTQ+ communities. The data included in the dataset are the reproducible search strategies (txt file) and the exported results of all citations from all databases (txt, ris, and.nbib files). These searches and exported result files contain all citations originating from the database searches that were considered for inclusion.
Keyword:: LGBTQ, Transgender, Firearms
Discipline:: Health Sciences

Lu-177 DOTATATE Anonymized Patient Datasets: Multi-Time Point Lu-177 SPECT/CT Scans

Creator:: Dewaraja, Yuni K and Van, Benjamin J
Description:: This publication contains anonymized SPECT/CT scans of two patients. Patient scans were taken at 4 different time points in the week following a therapeutic dose of Lu-177 DOTATATE. Both the SPECT and the co-registered CT are provided. All images are in DICOM format.
Keyword:: Lu-177, Dosimetry, Radionuclide, SPECT, and CT
Discipline:: Health Sciences

Y-90 PET/CT & SPECT/CT and Corresponding Contours Dataset 31JULY2020

Creator:: Van, Benjamin J. and Dewaraja, Yuni K.
Description:: Interest in quantitative imaging of Y-90 is growing because transarterial radioembolization (RE) with Y-90 loaded microspheres is a promising and minimally invasive treatment that is FDA approved for unresectable primary and metastatic liver tumors. These cancers are a leading cause of cancer mortality and morbidity. Radioembolization is a therapy that irradiates liver tumors with radioactive microspheres administered through a microcatheter placed in the hepatic arterial vasculature. Radioembolization is based on the principle that healthy liver and tumor are mainly vascularized by the portal vein and the hepatic artery respectively. As a result, radioactive microspheres are preferentially located in the lesions after they are administered via the hepatic artery.
Keyword:: Y-90, PET, SPECT, CT, Segmentation, Organ, Tumor, Label, Microsphere, Radioembolization, and SIRT
Citation to related publication:: Van, B. J., Dewaraja, Y. K., Sangogo, M. L., & Mikell, J. K. (2021). Y-90 SIRT: Evaluation of TCP variation across dosimetric models. EJNMMI Physics, 8(1), 45. https://doi.org/10.1186/s40658-021-00391-6
Discipline:: Health Sciences

Data pertaining to Article: Air Quality Impacts at an E-Waste Site in Ghana using Flexible, Low-Cost and Quality Assured Measurements

Creator:: Batterman, Stuart; University of Michigan
Description:: We evaluated PM levels at the Agbogbloshie e-waste and scrap yard site in Accra, Ghana, and at upwind and downwind locations. This monitoring forms part of the West Africa-Michigan Charter II for GEOHealth cohort study, which is analyzing occupational exposures and health risks at this site.
Keyword:: Air pollution, particulate matter, e-waste, Fires, and monitoring
Citation to related publication:: Kwarteng, L., Baiden, E. A., Fobil, J., Arko-Mensah, J., Robins, T., & Batterman, S. (2020). Air Quality Impacts at an E-Waste Site in Ghana Using Flexible, Moderate-Cost and Quality-Assured Measurements. GeoHealth, 4(8), e2020GH000247. https://doi.org/10.1029/2020GH000247
Discipline:: Health Sciences and Engineering

Data from: Adjuvant Radiation Improves Recurrence-Free Survival and Overall Survival in Adrenocortical Carcinoma

Creator:: Gharzai, Laila A, Green, Michael D, Griffith, Kent A, and Jolly, Shruti
Description:: Three sensitivity analyses were performed. First, a second matching step was performed in which two controls were selected for each case, where possible using a nearest neighbor and caliper metric. Controls needed to have propensity scores within 0.1 of the case to be selected. Thirty-eight of the 39 cases had at least one control using this method and for 36 cases two controls could be selected. The average difference between case and control propensity adjuvant RT was 0.008 (range 0.00003-0.095). A second sensitivity analysis was performed to guard against immortal time bias. In order to mitigate the possibility of this effect, cases known not to have undergone adjuvant RT have been screened for suitable follow-up without a recurrence (local or regional recurrence, metastatic failure, and/or death) to ensure that if adjuvant RT had been prescribed as part of the multi-modality treatment regimen, that it would have been initiated. Three months was selected as the mandatory follow-up time. One to one matching was carried out and all 39 cases were matched to a control. A third sensitivity analysis was performed to account for stage migration seen in control patients that presented to the University of Michigan with more advanced disease. Patients that underwent adjuvant radiation were matched one to one with control group patients who did not receive adjuvant radiation, and who had the same stage at diagnosis as compared to stage at University of Michigan presentation.
Keyword:: adenocortical carcinoma and English
Citation to related publication:: Laila A Gharzai, Michael D Green, Kent A Griffith, Tobias Else, Charles S Mayo, Elizabeth Hesseltine, Daniel E Spratt, Edgar Ben-Josef, Aaron Sabolch, Barbara S Miller, Francis Worden, Thomas J Giordano, Gary D Hammer, Shruti Jolly, Adjuvant Radiation Improves Recurrence-Free Survival and Overall Survival in Adrenocortical Carcinoma, The Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 9, September 2019, Pages 3743–3750, https://doi.org/10.1210/jc.2019-00029
Discipline:: Health Sciences

Transmission of Oral microbiome and Sequencing - Influenza Susceptibility

Creator:: Lee, Kyu Han, Foxman, Betsy, and Gordon, Aubree
Description:: Data include variables used to run mixed effects models examining the association between the nose/throat microbiome and influenza virus infection. Certain individual participant data have been excluded due to identifiability concerns. Data also include the oligotype count table and taxonomic classifications. and Curation Notes: Readme updated Nov. 29, 2018 with context for oligotype and taxonomy files, and citation to associated article.
Keyword:: Influenza and Microbiome
Citation to related publication:: Lee KH, Gordon A, Shedden K, Kuan G, Ng S, Balmaseda A, Foxman B. The respiratory microbiome and susceptibility to influenza virus infection. PloS One. 2019;14:e0207898. https://doi.org/10.1371/journal.pone.0207898
Discipline:: Health Sciences

Action current data for investigating the development and organization of GnRH neuron activity in mice.

Analyzing Reviewer Responses to Systematic Review Search Methodology through Open Peer Review

Lu-177 DOTATATE Anonymized Patient Datasets: Lu-177 SPECT Time Integrated Activity Maps

Lu-177 DOTATATE Anonymized Patient Datasets: Pre-therapy Diagnostic Images

Literature search files for Firearm violence among LGBTQ+ communities: A scoping review and future directions

Lu-177 DOTATATE Anonymized Patient Datasets: Multi-Time Point Lu-177 SPECT/CT Scans

Y-90 PET/CT & SPECT/CT and Corresponding Contours Dataset 31JULY2020

Data pertaining to Article: Air Quality Impacts at an E-Waste Site in Ghana using Flexible, Low-Cost and Quality Assured Measurements

Data from: Adjuvant Radiation Improves Recurrence-Free Survival and Overall Survival in Adrenocortical Carcinoma

Transmission of Oral microbiome and Sequencing - Influenza Susceptibility

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