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- Creator:
- Okullo, Dolorence, Yan, Xiang (Jacob), Data Driven Detroit, Veinot, Tiffany C., Gomez-Lopez, Iris N., and Goodspeed, Robert
- Description:
- The food environment is: 1) The physical presence of food that affects a person’s diet; 2) A person’s proximity to food store locations; 3) The distribution of food stores, food service, and any physical entity by which food may be obtained; or 4) A connected system that allows access to food. (Source: https://www.cdc.gov/healthyplaces/healthtopics/healthyfood/general.htm) Data included here concern: 1) Food access; and 2) Liquor access. Spatial Coverage for most data: 10-county Detroit-Warren-Ann Arbor Combined Statistical Area, Michigan, USA. See exception for grocery store data below.
- Keyword:
- Food Deserts, Census tract level, Full-Line Grocery Stores, Modified Retail Food Environment Index (MRFEI), Farmer’s Markets, Spatial Measures, and Fast Food Establishments
- Discipline:
- Social Sciences, Health Sciences, and Other
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- Creator:
- Yoshida, Sei and Swanson, Joel A
- Description:
- The rapid activation of the mechanistic target of rapamycin complex-1 (mTORC1) by growth factors is increased by extracellular amino acids through yet-undefined mechanisms of amino acid transfer into endolysosomes. Because the endocytic process of macropinocytosis concentrates extracellular solutes into endolysosomes and is increased in cells stimulated by growth factors or tumor-promoting phorbol esters, we analyzed its role in amino acid–dependent activation of mTORC1. Here, we show that growth factor-dependent activation of mTORC1 by amino acids, but not glucose, requires macropinocytosis. In murine bone marrow–derived macrophages and murine embryonic fibroblasts stimulated with their cognate growth factors or with phorbol myristate acetate, activation of mTORC1 required an Akt-independent vesicular pathway of amino acid delivery into endolysosomes, mediated by the actin cytoskeleton. Macropinocytosis delivered small, fluorescent fluid-phase solutes into endolysosomes sufficiently fast to explain growth factor–mediated signaling by amino acids. Therefore, the amino acid–laden macropinosome is an essential and discrete unit of growth factor receptor signaling to mTORC1
- Keyword:
- growth factor signaling, Macropinosomes, and mTORC1
- Discipline:
- Health Sciences
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- Creator:
- Larson, Ronald G., Wen, Fei, Huang, Wenjun, and Huang, Ming
- Description:
- We provide the parameters used in Umbrella Sampling simulations reported in our study "Efficient Estimation of Binding Free Energies between Peptides and an MHC Class II Molecule Using Coarse-Grained Molecular Dynamics Simulations with a Weighted Histogram Analysis Method", namely the set positions and spring constants for each window in simulations. Two tables are provided. Table 1 lists the names of the peptides and their corresponding sequences. Table 2 lists the parameters. The abstract of our work is the following: We estimate the binding free energy between peptides and an MHC class II molecule using molecular dynamics (MD) simulations with Weighted Histogram Analysis Method (WHAM). We show that, owing to its more thorough sampling in the available computational time, the binding free energy obtained by pulling the whole peptide using a coarse-grained (CG) force field (MARTINI) is less prone to significant error induced by biased-sampling than using an atomistic force field (AMBER). We further demonstrate that using CG MD to pull 3-4 residue peptide segments while leaving the remain-ing peptide segments in the binding groove and adding up the binding free energies of all peptide segments gives robust binding free energy estimations, which are in good agreement with the experimentally measured binding affinities for the peptide sequences studied. Our approach thus provides a promising and computationally efficient way to rapidly and relia-bly estimate the binding free energy between an arbitrary peptide and an MHC class II molecule.
- Keyword:
- Molecular Dynamics, Binding Free Energy, Protein, MHC, and Coarse-Grained
- Discipline:
- Science and Engineering
-
- Creator:
- Okullo, Dolorence, Gomez-Lopez, Iris N., Goodspeed, Robert, Reddy, Shruthi, Veinot, Tiffany C, Clarke, Phillipa J., and Data Driven Detroit
- Description:
- The information and education environment refers to: 1) the presence of information infrastructures such as broadband Internet access and public libraries in a location; 2) a person’s proximity to information infrastructures and sources; 3) the distribution of information infrastructures, sources and in a specific location; and 4) exposure to specific messages (information content) within a specific location. Coverage for all data: 10-county Detroit-Warren-Ann Arbor Combined Statistical Area.
- Keyword:
- Residential Broadband Data Adoption Rates, Census tract level, Broadband Internet Access and Speed, Colleges and Universities, Public Libraries, Spatial Measures, and Schools
- Discipline:
- Science, Social Sciences, and Health Sciences
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- Creator:
- Jones, Monica L.H.
- Description:
- This study evaluated the performance of a video-based intervention for improving the belt fit obtained by drivers. Previous laboratory studies have demonstrated that some drivers position their seat belts suboptimally. Specifically, the lap portion of the belt may be higher and farther forward relative to the pelvis than best practice, and the shoulder portion of the belt may be outboard or inboard of mid-shoulder. A video was developed to present the most important aspects of belt fit best practices, with emphasis on the lap belt. The video demonstrated how a seat belt should be routed with respect to an individual’s anatomy to ensure a proper fit. The three key belt fit concepts conveyed in the video were: 1) Lap belt low on hips, touching the thighs. 2) Shoulder belt crossing middle of collarbone. 3) Belt snug, as close to bones as possible. Additional context about the ability to achieve to good belt fit, such as opening a heavy coat or adjusting the height adjusters on the B-pillar behind the windows, were also presented.
- Keyword:
- Safety, Seatbelt Fit, Intervention, and Evaluation
- Citation to related publication:
- Jones, M.L.H., Ebert, S.M., Buckley, L., Park, J., and Reed, M.P. (2016). Evaluating an Intervention to Improve Belt Fit for Drivers. Technical Report UMTRI 2016-12. University of Michigan Transportation Research Institute, Ann Arbor, MI. , Reed, M.P., Ebert-Hamilton, S.M. and Rupp, J.D. (2012). Effects of obesity on seat belt fit. Traffic Injury Prevention, 13(4):364-372. https://doi.org/10.1080/15389588.2012.659363, Reed, M.P., Ebert, S.M. and Hallman, J.J. (2013). Effects of driver characteristics on seat belt fit. Stapp Car Crash Journal, 57:43-57. https://pubmed.ncbi.nlm.nih.gov/24435726/, and Jones, M.L.H., Ebert, S.M., and Reed, M.P. (2015). Effects of High Levels of Obesity on Driver Seat Belt Fit. Advancing Transportation Leadership and Safety Technical Report ATLAS-2015-016. University of Michigan Transportation Research Institute, Ann Arbor, MI. https://trid.trb.org/view/1427384 http://www.atlas-center.org/wp-content/uploads/2015/08/ATLAS-Final-Report-ATLAS-2016-15.pdf
- Discipline:
- Engineering
-
- Creator:
- Jones, Monica L.H.
- Description:
- These manikins represent body shape models for children weighing 9 to 23 kg in a seated posture relevant to child restraint design. The design of child restraints is guided in part by anthropometric data describing the distributions of body dimensions of children. However, three-dimensional body shape data have not been available for children younger than three years of age. These manikins will be useful for assessing child accommodation in restraints. The SBSM can also provide guidance for the development of anthropomorphic test devices and computational models of child occupants. The sampled manikins were predicted for a range of torso length and body weight dimensions. The SBSM model was exercised for two torso lengths and nine body weights to obtain 18 body shapes. The 3D shape models can be downloaded in a standard mesh format (PLY). Each body shape is accompanied by predicted landmark locations and standard anthropometric variables.
- Keyword:
- Child anthropometry, Child restraint system, Statistical body shape model, and Anthropomorphic testing device (ATD)
- Discipline:
- Engineering
-
- Creator:
- Grosky, William I. and Ruas, Terry L.
- Description:
- This dataset was used for a proof-of-concept of fixed lexical chain approach for semantic information retrieval.
- Keyword:
- fixed lexical chains
- Citation to related publication:
- Ruas, T. L., & Grosky, W. I. (2017). Exploring and expanding the use of lexical chains in information retrieval. Ann Arbor: University of Michigan. Retrieved from the Deep Blue institutional repository website: http://dx.doi.org/10.3998/2027.42/136659
- Discipline:
- Engineering
-
- Creator:
- James, David A.
- Description:
- An Excel spreadsheet listing the information recorded on each of 18,686 costume designs can be viewed, downloaded, and explored. All the usual Excel sorting possibilities are available, and in addition a useful filter has been installed. For example, to find the number of designs that are Frieze Type #1, go to the top of the frieze type 2 column (column AS), click on the drop-down arrow and unselect every option box except True (i.e. True should be turned on, all other choices turned off). Then in the lower left corner, one reads “1111 of 18686 records found”. Much more sophisticated exploration can be carried out by downloading the rich and flexible Access Database. The terms used for this database were described in detail in three sections of Deep Blue paper associated with this project. The database can be downloaded and explored. HOW TO USE THE ACCESS DATABASE 1. Click on the Create Cohort and View Math Trait Data button, and select your cohort by clicking on the features of interest (for example: Apron and Blouse). Note: Depending on how you exited on your previous visit to the database, there may be items to clear up before creating the cohorts. a) (Usually unnecessary) Click on the small box near the top left corner to allow connection to Access. b) (Usually unnecessary) If an undesired window blocks part of the screen, click near the top of this window to minimize it. c) Make certain under Further Filtering that all four Exclude boxes are checked to get rid of stripes and circles, and circular buttons, and the D1 that is trivially associated with shoes. 2. Click on Filter Records to Form the Cohort button. Note the # of designs, # of pieces, and # of costumes beside Recalculate. 3. Click on Calculate Average Math Trait Frequency of Cohort button, and select the symmetry types of interest (for example: D1 and D2) . 4. To view the Stage 1 table, click on Create Stage 1 table. To edit and print this table, click on Create Excel (after table has been created). The same process works for Stages 2, 3.and 4 tables. 5. To view the matrix listing the math category impact numbers, move over to a button on the right side and click on View Matrix of Math Category Impact Numbers. To edit and print this matrix, click on Create Excel, use the Excel table as usual.
- Keyword:
- Group Theory, European regional costume, Symmetry, Ethnomathematics, European folk costume, and Classification of designs
- Discipline:
- Other
-
- Creator:
- Keppel-Aleks, Gretchen and Liptak, Jessica
- Description:
- -CESM_bdrd _NEP_pulse_response_CO2.nc contains time series from the ‘FullyCoupled’ simulation -CESM_bdrcs_NEP_pulse_response_CO2.nc contains time series from the ‘NoRad’ simulation -CESM_bdrd_pftcon_NEP_pulse_response_CO2.nc contains data from the ‘NoLUC’ simulation -CESM_bdrd_Regional_Fluxes_NEP.nc contains NEP time series for each terrestrial source region from the FullyCoupled simulation - CESM_bdrcs_Regional_Fluxes_NEP.nc contains NEP time series for each terrestrial source region from the CESM ‘NoRad’ simulation - CESM_bdrd_pftcon_Regional_Fluxes_NEP.nc contains NEP time series for each terrestrial source region from the CESM ‘NoLUC’ simulation The 3-letter station IDs, latitudes, and longitudes of the sample locations are: ID Latitude (ºN) Longitude (ºE) 1. BRW 71.3 203.4 2. ZEP 78.9 11.9 3. SHM 52.7 174.1 4. THD 41.1 235.8 5. TAP 36.7 126.1 6. BMW 32.3 295.1 7. MLO 19.5 204.4 8. POCN15 15.0 215.0 9. ALT 82.5 297.5 10. BHD -41.4 174.9 11. EIC -27.2 250.6 12. GMI 13.4 144.7 13. HUN 47.0 16.7 14. IZO 28.3 343.5 15. LLN 23.5 120.9 16. NAT -5.8 324.7 17. WLG 36.3 100.9 18. HBA -75.6 333.8 19. BKT -0.20 100.3 20. UUM 44.5 111.1 21. CGO -40.7 144.5 22. SDZ 40.7 117.1 23. ASC -8.0 345.6 24. SEY -4.7 55.5 25. POCS20 -20.0 186.0 26. POCS35 -35.0 180.0 27. PSA -64.9 296.0 28. SYO -69.0 39.6 29. CHR 1.7 202.8 30. KEY 25.7 279.8 31. BAL 55.4 17.2 32. HPB 47.8 11.0 33. LMP 35.5 12.6 34. NMB -23.6 15.0 35. RPB 13.2 300.2 36. WIS 30.0 35.1 37. POCS10 -10.0 199.0 38. POCN10 10.0 211.0 39. MID 28.2 182.6 40. SMO -14.2 189.4 41. SPO -90.0 335.2 The terrestrial CO2 source region abbreviations are: 1. NBNA 2. SBNA 3. ETNA 4. WTNA 5. CNAM 6. AMZN 7. EASA 8. WESA 9. EURO 10. SAME 11. MDAF 12. AFRF 13. SOAF 14. EABA 15. WEBA 16. SOBA 17. CNAS 18. SEAS 19. EQAS 20. AUST 21. GNLD 22. ATCA
- Keyword:
- atmospheric CO2 annual cycle amplitude and CESM extended concentration pathway
- Citation to related publication:
- Hornick, T., Bach, L. T., Crawfurd, K. J., Spilling, K., Achterberg, E. P., Woodhouse, J. N., Schulz, K. G., Brussaard, C. P. D., Riebesell, U., & Grossart, H.-P. (2017). Ocean acidification impacts bacteria–phytoplankton coupling at low-nutrient conditions. Biogeosciences, 14(1), 1–15. https://doi.org/10.5194/bg-14-1-2017
- Discipline:
- Science
-
- Creator:
- Malik, Hafiz and Khan, Muhammad Khurran, King Saud University
- Description:
- Details of the microphone used for data collection, acoustic environment in which data was collected, and naming convention used are provided here. 1 - Microphones Used: The microphones used to collect this dataset belong to 7 different trademarks. Table (1) illustrates the number of used Mics of different trademarks and models. Table 1: Trademarks and models of Mics Mic Trademark Mic Model # of Mics Shure SM-58 3 Electro-Voice RE-20 2 Sennheiser MD-421 3 AKG C 451 2 AKG C 3000 B 2 Neumann KM184 2 Coles 4038 2 The t.bone MB88U 6 Total 22 2- Environment Description: A brief description of the 6 environments in which the dataset was collected is presented here: (i) Soundproof room: a small room (nearly 1.5m × 1.5m × 2m), which is closed and completely isolated. With an exception of a small window in the front side of the room which is made of glass, all the walls of the room are made of wood and covered by a layer of sponge from the inner side, and the floor is covered by carpet. (ii) Class room: standard class room (6m × 5m × 3m). (iii) Lab: small lab (4m × 4m × 3m). All the walls are made of glasses and the floor is covered by carpet. The lab contains 9 computers. (iv) Stairs: is in the second floor. The place of recording is 3m × 5m (v) Parking: is the college parking. (vi) Garden: is an open space outside the buildings. 3- Naming Convention: This set of rules were followed as a naming convention to give each file in the dataset a unique name: (i) The file name is 19 characters long, and consists of 5 sections separated by underscores. (ii) The first section is of 3 characters indicates the Microphone trademark. (iii) The second section of 4 characters indicates the microphone model as in table (2). (iv) The third section of 2 characters indicates a specific microphone within a set of microphones of the same trademark and model, since we have more than one microphone of the same trademark and model. (v) The fourth section of 2 characters indicates the environment, where Soundproof room --> 01 Class room --> 02 Lab --> 03 Stairs --> 04 Parking --> 05 Garden --> 06 (vi) The fifth section of 2 characters indicates the language, where Arabic --> 01 English --> 02 Chinese --> 03 Indonesian --> 04 (vii) The sixth section of 2 characters indicates the speaker. Table 2: Microphones Naming Criteria Original Mic Trademark and model --> Naming Convenient Shure SM-58 --> SHU_0058 Electro-Voice RE-20 --> ELE_0020 Sennheiser MD-421 --> SEN_0421 AKG C 451 --> AKG_0451 AKG C 3000 B --> AKG_3000 Neumann KM184 --> NEU_0184 Coles 4038 --> COL_4038 The t.bone MB88U --> TBO_0088 For example: SEN_0421_02_01_02_03 is an English file recorded by speaker number 3 in the soundproof room using microphone number 2 of Sennheiser MD-421
- Keyword:
- audio forensic, multimedia forensics, microphone identification, tamper detection, splicing detection, and codec identification
- Citation to related publication:
- Muhammad Khurram Khan, Mohammed Zakariah, Hafiz Malik & Kim-Kwang Raymond Choo (2018). A novel audio forensic data-set for digital multimedia forensics, Australian Journal of Forensic Sciences, 50:5, 525-542, http://dx.doi.org/10.1080/00450618.2017.1296186
- Discipline:
- Engineering, Government, Politics and Law, and Science