Work Description

Title: Pharmacometabolomics of L-carnitine-Kaplan-Meier survival data: numbers at risk Open Access Deposited

h
Attribute Value
Methodology
  • Survival analysis was performed on a sub-group of septic shock patients from the RACE trial (https://clinicaltrials.gov/ct2/show/NCT01665092) that received either L-carnitine (18g) or placebo based on pre-treatment serum acetylcarnitine or valine concentration. Acylcarnitines (including acetylcarnitine) were measured using LC-MS and valine, a branched chain amino acid, was measured by nuclear magnetic resonance (NMR)-spectroscopy.
Description
  • These data were produced from the survival analysis of the pre-treatment metabolomics data generated from the Phase II clinical trial of L-carnitine treatment for septic shock (the RACE trial - see https://clinicaltrials.gov/ct2/show/NCT01665092). The results based on respective acetylcarnitine or valine concentration are presented (pdf). The csv files contain the at risk numbers from the Kaplan-Meier survival analysis. These findings described in our manuscript: Pharmacometabolomics Identifies Candidate Predictor Metabolites of an L-carnitine Treatment Mortality Benefit in Septic Shock.

  • All of the metabolomics data are available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org which is supported by NIH grant U2C-DK119886 and where it has been assigned Project ID (accession number ST001319). The data can be accessed directly via its Project DOIs: (DOI: http://dx.doi.org/10.21228/M8VX0Z).
Creator
Depositor
  • stringek@umich.edu
Contact information
Discipline
Funding agency
  • National Institutes of Health (NIH)
ORSP grant number
  • AWD002688
Keyword
Citations to related material
  • Puskarich, M. A., Jennaro, T. S., Gillies, C. E., Evans, C. R., Karnovsky, A., McHugh, C. E., Flott, T. L., Jones, A. E., Stringer, K. A., & Investigators, O. behalf of the R. T. (2021). Pharmacometabolomics Identifies Candidate Predictor Metabolites of an L-carnitine Treatment Mortality Benefit in Septic Shock. (Preprint) https://doi.org/10.1101/2021.01.28.21250687
Resource type
Last modified
  • 11/19/2022
Published
  • 02/10/2021
Language
DOI
  • https://doi.org/10.7302/vvqp-ma61
License
To Cite this Work:
Stringer, K. A. (2021). Pharmacometabolomics of L-carnitine-Kaplan-Meier survival data: numbers at risk [Data set], University of Michigan - Deep Blue Data. https://doi.org/10.7302/vvqp-ma61

Relationships

This work is not a member of any user collections.

Files (Count: 17; Size: 784 KB)

Thumbnailthumbnail-column Title Original Upload Last Modified File Size Access Actions
READ_ME.txt 2021-02-03 2021-02-05 4.1 KB Open Access
SA-at_risk_L-carnitine_18g_v_PL_...s.csv 2021-02-05 2021-02-05 599 Bytes Open Access
SA-at_risk_35uM_L-carnitine_18g_...e.csv 2021-02-05 2021-02-05 261 Bytes Open Access
SA-at_risk_30uM_L-carnitine_18g_...e.csv 2021-02-05 2021-02-05 284 Bytes Open Access
SA-at_risk_21uM_L-carnitine_18g_...e.csv 2021-02-05 2021-02-05 380 Bytes Open Access
SA-at_risk_L-carnitine_18g_v_PL_...s.csv 2021-02-05 2021-02-05 585 Bytes Open Access
SA-at_risk_88uM_L-carnitine_18g_...e.csv 2021-02-05 2021-02-05 384 Bytes Open Access
SA-at_risk_75uM_L-carnitine_18g_...e.csv 2021-02-05 2021-02-05 477 Bytes Open Access
SA-at_risk_60uM_L-carnitine_18g_...e.csv 2021-02-05 2021-02-05 535 Bytes Open Access
SA-acylcarnitines-all_subjects.pdf 2021-02-05 2021-02-05 100 KB Open Access
SA-acetylcarnitine-21uM.pdf 2021-02-05 2021-02-05 96.2 KB Open Access
SA-acetylcarnitine-30uM.pdf 2021-02-05 2021-02-05 95.3 KB Open Access
SA-acetylcarnitine-35uM.pdf 2021-02-05 2021-02-05 90.4 KB Open Access
SA-NMR_data-all_subjects.pdf 2021-02-05 2021-02-05 102 KB Open Access
SA-NMR_data-valine-60uM.pdf 2021-02-05 2021-02-05 101 KB Open Access
SA-NMR_data-valine-75uM.pdf 2021-02-05 2021-02-05 95.9 KB Open Access
SA-NMR_data-valine-88uM.pdf 2021-02-05 2021-02-05 95.7 KB Open Access
"Survival analyses conducted in an ancillary study of the RACE trial (https://clinicaltrials.gov/ct2/show/NCT01665092) of patients that received either L-carnitine (18g dose) or placebo using a range of pre-treatment serum acetylcarnitine and valine concentrations as measured by LC-MS or NMR, respectively" CSV files: represent the number of at risk subjects for each representative Kaplan Meier analysis (pdf) for each acetylcarnitine (LC-MS) or valine (NMR) concentration scenario (including one for all patients) for patients that received either L-carnitine (18g) or placebo CSV file name: SA-at risk L-carnitine 18g v PL acetylcarnitine- all pts: represents the at risk subjects at various time points that received either L-carnitine (18g) or placebo CSV file name: SA-at risk 35然 L-carnitine 18g v PL acetylcarnitine: represents the at risk subjects at various time points that received either L-carnitine (18g) or placebo that had pre-treatment serum acetylcarnitine concentrations of 35然 or above CSV file name: SA-at risk 30然 L-carnitine 18g v PL acetylcarnitine: represents the at risk subjects at various time points that received either L-carnitine (18g) or placebo that had pre-treatment serum acetylcarnitine concentrations of 30然 or above CSV file name: SA-at risk 21然 L-carnitine 18g v PL acetylcarnitine: represents the at risk subjects at various time points that received either L-carnitine (18g) or placebo that had pre-treatment serum acetylcarnitine concentrations of 21然 or above CSV file name: SA-at risk L-carnitine 18g v PL valine- all pts: represents the at risk subjects at various time points that received either L-carnitine (18g) or placebo CSV file name: SA-at risk 88然 L-carnitine 18g v PL valine: represents the at risk subjects at various time points that received either L-carnitine (18g) or placebo that had pre-treatment serum valine concentrations of 88然 or above CSV file name: SA-at risk 75然 L-carnitine 18g v PL valine: represents the at risk subjects at various time points that received either L-carnitine (18g) or placebo that had pre-treatment serum valine concentrations of 75然 or above CSV file name: SA-at risk 60然 L-carnitine 18g v PL valine: represents the at risk subjects at various time points that received either L-carnitine (18g) or placebo that had pre-treatment serum valine concentrations of 60然 or above PDF files: show the results of the survival analysis for each acetylcarnitine (LC-MS) or valine (NMR) pre-treatment concentration scenario as well as one for all patients that received either L-carnitine (18g) or placebo including the associated statistical analysis PDF name: SA-acylcarnitines-all subjects: shows the survival analysis results for patients that received either L-carnitine (18g) or placebo for which acylcarnitine data were obtained PDF name: SA-acetylcarnitine-21然: shows the survival analysis results for patients that received either L-carnitine (18g) or placebo that had pretreatment serum concentrations of 21然 or above PDF name: SA-acetylcarnitine-30然: shows the survival analysis results for patients that received either L-carnitine (18g) or placebo that had pretreatment serum concentrations of 30然 or above PDF name: SA-acetylcarnitine-35uM: shows the survival analysis results for patients that received either L-carnitine (18g) or placebo that had pretreatment serum concentrations of 35然 or above PDF name: SA-NMR data-all subjects: shows the survival analysis results for patients that received either L-carnitine (18g) or placebo for which NMR data were obtained PDF name: SA-NMR data-valine-60然: shows the survival analysis results for patients that received either L-carnitine (18g) or placebo that had pretreatment serum concentrations of 60然 or above PDF name: SA-NMR data-valine-75然: shows the survival analysis results for patients that received either L-carnitine (18g) or placebo that had pretreatment serum concentrations of 75然 or above PDF name: SA-NMR data-valine-88然: shows the survival analysis results for patients that received either L-carnitine (18g) or placebo that had pretreatment serum concentrations of 88然 or above

Download All Files (To download individual files, select them in the Files panel above)

Best for data sets < 3 GB. Downloads all files plus metadata into a zip file.



Best for data sets > 3 GB. Globus is the platform Deep Blue Data uses to make large data sets available.   More about Globus

Remediation of Harmful Language

The University of Michigan Library aims to describe its collections in a way that respects the people and communities who create, use, and are represented in them. We encourage you to contact us anonymously if you encounter harmful or problematic language in catalog records or finding aids. More information about our policies and practices is available at Remediation of Harmful Language.