Work Description

Title: Pharmacometabolomics of L-carnitine-Kaplan-Meier survival data: numbers at risk Open Access Deposited

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Attribute Value
Methodology
  • Survival analysis was performed on a sub-group of septic shock patients from the RACE trial (https://clinicaltrials.gov/ct2/show/NCT01665092) that received either L-carnitine (18g) or placebo based on pre-treatment serum acetylcarnitine or valine concentration. Acylcarnitines (including acetylcarnitine) were measured using LC-MS and valine, a branched chain amino acid, was measured by nuclear magnetic resonance (NMR)-spectroscopy.
Description
  • These data were produced from the survival analysis of the pre-treatment metabolomics data generated from the Phase II clinical trial of L-carnitine treatment for septic shock (the RACE trial - see https://clinicaltrials.gov/ct2/show/NCT01665092). The results based on respective acetylcarnitine or valine concentration are presented (pdf). The csv files contain the at risk numbers from the Kaplan-Meier survival analysis. These findings described in our manuscript: Pharmacometabolomics Identifies Candidate Predictor Metabolites of an L-carnitine Treatment Mortality Benefit in Septic Shock.

  • All of the metabolomics data are available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org which is supported by NIH grant U2C-DK119886 and where it has been assigned Project ID (accession number ST001319). The data can be accessed directly via its Project DOIs: (DOI: http://dx.doi.org/10.21228/M8VX0Z).
Creator
Depositor
  • stringek@umich.edu
Contact information
Discipline
Funding agency
  • National Institutes of Health (NIH)
ORSP grant number
  • AWD002688
Keyword
Citations to related material
  • Puskarich, M. A., Jennaro, T. S., Gillies, C. E., Evans, C. R., Karnovsky, A., McHugh, C. E., Flott, T. L., Jones, A. E., Stringer, K. A., & Investigators, O. behalf of the R. T. (2021). Pharmacometabolomics Identifies Candidate Predictor Metabolites of an L-carnitine Treatment Mortality Benefit in Septic Shock. (Preprint) https://doi.org/10.1101/2021.01.28.21250687
Resource type
Last modified
  • 11/19/2022
Published
  • 02/10/2021
Language
DOI
  • https://doi.org/10.7302/vvqp-ma61
License
To Cite this Work:
Stringer, K. A. (2021). Pharmacometabolomics of L-carnitine-Kaplan-Meier survival data: numbers at risk [Data set], University of Michigan - Deep Blue Data. https://doi.org/10.7302/vvqp-ma61

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Files (Count: 17; Size: 784 KB)

Thumbnailthumbnail-column Title Original Upload Last Modified File Size Access Actions
READ_ME.txt 2021-02-03 2021-02-05 4.1 KB Open Access
SA-at_risk_L-carnitine_18g_v_PL_...s.csv 2021-02-05 2021-02-05 599 Bytes Open Access
SA-at_risk_35uM_L-carnitine_18g_...e.csv 2021-02-05 2021-02-05 261 Bytes Open Access
SA-at_risk_30uM_L-carnitine_18g_...e.csv 2021-02-05 2021-02-05 284 Bytes Open Access
SA-at_risk_21uM_L-carnitine_18g_...e.csv 2021-02-05 2021-02-05 380 Bytes Open Access
SA-at_risk_L-carnitine_18g_v_PL_...s.csv 2021-02-05 2021-02-05 585 Bytes Open Access
SA-at_risk_88uM_L-carnitine_18g_...e.csv 2021-02-05 2021-02-05 384 Bytes Open Access
SA-at_risk_75uM_L-carnitine_18g_...e.csv 2021-02-05 2021-02-05 477 Bytes Open Access
SA-at_risk_60uM_L-carnitine_18g_...e.csv 2021-02-05 2021-02-05 535 Bytes Open Access
SA-acylcarnitines-all_subjects.pdf 2021-02-05 2021-02-05 100 KB Open Access
SA-acetylcarnitine-21uM.pdf 2021-02-05 2021-02-05 96.2 KB Open Access
SA-acetylcarnitine-30uM.pdf 2021-02-05 2021-02-05 95.3 KB Open Access
SA-acetylcarnitine-35uM.pdf 2021-02-05 2021-02-05 90.4 KB Open Access
SA-NMR_data-all_subjects.pdf 2021-02-05 2021-02-05 102 KB Open Access
SA-NMR_data-valine-60uM.pdf 2021-02-05 2021-02-05 101 KB Open Access
SA-NMR_data-valine-75uM.pdf 2021-02-05 2021-02-05 95.9 KB Open Access
SA-NMR_data-valine-88uM.pdf 2021-02-05 2021-02-05 95.7 KB Open Access
"Survival analyses conducted in an ancillary study of the RACE trial (https://clinicaltrials.gov/ct2/show/NCT01665092) of patients that received either L-carnitine (18g dose) or placebo using a range of pre-treatment serum acetylcarnitine and valine concentrations as measured by LC-MS or NMR, respectively" CSV files: represent the number of at risk subjects for each representative Kaplan Meier analysis (pdf) for each acetylcarnitine (LC-MS) or valine (NMR) concentration scenario (including one for all patients) for patients that received either L-carnitine (18g) or placebo CSV file name: SA-at risk L-carnitine 18g v PL acetylcarnitine- all pts: represents the at risk subjects at various time points that received either L-carnitine (18g) or placebo CSV file name: SA-at risk 35然 L-carnitine 18g v PL acetylcarnitine: represents the at risk subjects at various time points that received either L-carnitine (18g) or placebo that had pre-treatment serum acetylcarnitine concentrations of 35然 or above CSV file name: SA-at risk 30然 L-carnitine 18g v PL acetylcarnitine: represents the at risk subjects at various time points that received either L-carnitine (18g) or placebo that had pre-treatment serum acetylcarnitine concentrations of 30然 or above CSV file name: SA-at risk 21然 L-carnitine 18g v PL acetylcarnitine: represents the at risk subjects at various time points that received either L-carnitine (18g) or placebo that had pre-treatment serum acetylcarnitine concentrations of 21然 or above CSV file name: SA-at risk L-carnitine 18g v PL valine- all pts: represents the at risk subjects at various time points that received either L-carnitine (18g) or placebo CSV file name: SA-at risk 88然 L-carnitine 18g v PL valine: represents the at risk subjects at various time points that received either L-carnitine (18g) or placebo that had pre-treatment serum valine concentrations of 88然 or above CSV file name: SA-at risk 75然 L-carnitine 18g v PL valine: represents the at risk subjects at various time points that received either L-carnitine (18g) or placebo that had pre-treatment serum valine concentrations of 75然 or above CSV file name: SA-at risk 60然 L-carnitine 18g v PL valine: represents the at risk subjects at various time points that received either L-carnitine (18g) or placebo that had pre-treatment serum valine concentrations of 60然 or above PDF files: show the results of the survival analysis for each acetylcarnitine (LC-MS) or valine (NMR) pre-treatment concentration scenario as well as one for all patients that received either L-carnitine (18g) or placebo including the associated statistical analysis PDF name: SA-acylcarnitines-all subjects: shows the survival analysis results for patients that received either L-carnitine (18g) or placebo for which acylcarnitine data were obtained PDF name: SA-acetylcarnitine-21然: shows the survival analysis results for patients that received either L-carnitine (18g) or placebo that had pretreatment serum concentrations of 21然 or above PDF name: SA-acetylcarnitine-30然: shows the survival analysis results for patients that received either L-carnitine (18g) or placebo that had pretreatment serum concentrations of 30然 or above PDF name: SA-acetylcarnitine-35uM: shows the survival analysis results for patients that received either L-carnitine (18g) or placebo that had pretreatment serum concentrations of 35然 or above PDF name: SA-NMR data-all subjects: shows the survival analysis results for patients that received either L-carnitine (18g) or placebo for which NMR data were obtained PDF name: SA-NMR data-valine-60然: shows the survival analysis results for patients that received either L-carnitine (18g) or placebo that had pretreatment serum concentrations of 60然 or above PDF name: SA-NMR data-valine-75然: shows the survival analysis results for patients that received either L-carnitine (18g) or placebo that had pretreatment serum concentrations of 75然 or above PDF name: SA-NMR data-valine-88然: shows the survival analysis results for patients that received either L-carnitine (18g) or placebo that had pretreatment serum concentrations of 88然 or above

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