Now showing items 151-160 of 172
Optimal dynamic treatment regime estimation using information extraction from unstructured clinical text
(Chapman and Hall/CRCWiley Periodicals, Inc., 2022-04)
The wide-scale adoption of electronic health records (EHRs) provides extensive information to support precision medicine and personalized health care. In addition to structured EHRs, we leverage free-text clinical information ...
A utility approach to individualized optimal dose selection using biomarkers
(Wiley Periodicals, Inc., 2020-03)
In many settings, including oncology, increasing the dose of treatment results in both increased efficacy and toxicity. With the increasing availability of validated biomarkers and prediction models, there is the potential ...
Mapping, Tracking and Modeling the Movements of Single Membrane-Bound Transcription Activator Proteins in Live Vibrio cholerae.
(2014)
Cholera has been known since ancient times, yet there is still no cure. Vibrio cholerae bacteria cause cholera by producing cholera toxin. Cholera toxin production is regulated by the protein ToxT, which itself is regulated ...
Ultrafast Hydration Dynamics Near Extended Macromolecular Interfaces
(2019)
Liquid water is arguably the most complex, but interesting chemical, enabling development and sustenance of life. The tetrahedral geometry of the water molecule allows the formation of a dense network of hydrogen bonds ...
A Tale of Two RNAs: Single Molecule Investigation of the Conformation, Dynamics and Ligand Binding to the PreQ1 and T-box Riboswitches.
(2014)
Riboswitches are structured mRNA domains that can bind cellular metabolites and control gene expression of downstream genes mainly via transcription attenuation or inhibition of translation initiation. Although structures ...
Biophysical Approaches to Target Protein-Protein Interactions of Epigenetic Complexes by Small-Molecule Inhibitors
(2019)
Innumerable biological systems rely on Protein-Protein Interactions (PPIs) to govern basal physiological processes. Deregulation of PPIs is implicated in various human diseases, and PPIs have thus been frequently promoted ...
Probing Local Atomic Environments to Model RNA Energetics and Structure
(2020)
Ribonucleic acids (RNA) are critical components of living systems. Understanding RNA structure and its interaction with other molecules is an essential step in understanding RNA-driven processes within the cell. Experimental ...
Structural Dynamics of the Hepatitis Delta Virus and Hairpin Ribozymes: Implications for Function.
(2014)
Small catalytic RNAs (ribozymes) are a class of RNAs less than 200 nucleotides in length, which are able to catalyze both cleavage and subsequent re-ligation of their own phosphodiester backbones. Cleavage results in ...
Observations of Coherence in Bacterial Reaction Centers Using Two-Dimensional Electronic Spectroscopy
(2018)
Photosynthesis is the process by which plants and photosynthetic bacteria convert absorbed sunlight into usable chemical energy. In the first steps of photosynthesis, light energy absorbed by molecules embedded in ...
Probing Ultrafast Dynamics of Bacterial Reaction Centers Using Two-Dimensional Electronic Spectroscopy
(2017)
In the initial steps of photosynthesis, solar energy is converted to stable charge separated states with high efficiency. Understanding the relationship between structure and function in the photosynthetic reaction centers ...