Now showing items 61-70 of 1943
More TORC for the gluconeogenic engine
(Wiley Subscription Services, Inc., A Wiley Company, 2006-03)
Hepatic gluconeogenesis plays a key role in the maintenance of glucose homeostasis. The hormone glucagon stimulates this process, whereas insulin and adiponectin are inhibitory. In a recent report, Koo et al identify the ...
Determination of Binding Mode: Intercalation
(Academic PressWiley Periodicals, Inc., 2000-02)
A small molecule can be assumed to bind to DNA by intercalation between base pairs if it causes lengthening and unwinding of the DNA helix and undergoes changes in its spectral properties, such as DNA‐induced hypochromism ...
An Empirical Model for Estimating Remediation Costs at Contaminated Sites
(Kluwer Academic Publishers; Springer Science + Business Media, Inc., 2005-10)
A model for estimating the remediation costs at contaminated sites is developed, in which the predictor variable is a composite of surface, subsurface, and contaminant risk factors. Calibration of the model is performed ...
Retrievable hydrogels for ovarian follicle transplantation and oocyte collection
(American Cancer SocietyWiley Periodicals, Inc., 2018-08)
Cancer survivorship rates have drastically increased due to improved efficacy of oncologic treatments. Consequently, clinical concerns have shifted from solely focusing on survival to quality of life, with fertility ...
Using P-Splines to Estimate Nonlinear Covariate Effects in Latent Factor Models.
(2015)
Latent factor models are useful for summarizing information among multiple outcomes. In this thesis I apply semiparametric methods based on P-splines to latent factor models in order to estimate and test non-constant factor ...
Rareâ variant association tests in longitudinal studies, with an application to the Multiâ Ethnic Study of Atherosclerosis (MESA)
(Wiley Periodicals, Inc.Springer New York, 2017-12)
Over the past few years, an increasing number of studies have identified rare variants that contribute to trait heritability. Due to the extreme rarity of some individual variants, geneâ based association tests have been ...
Early events of Bacillus anthracis germination identified by time-course quantitative proteomics
(WILEY-VCH Verlag, 2006-10)
Germination of Bacillus anthracis spores involves rehydration of the spore interior and rapid degradation of several of the protective layers, including the spore coat. Here, we examine the temporal changes that occur ...
Cellular Delivery of Locked Nucleic Acids (LNAs)
(Wiley Periodicals, Inc., 2002-06)
Locked nucleic acids (LNAs) are RNA derivatives that have an O‐methylene linkage between the 2 and 4 positions of the ribose. This leads to exceptionally high‐affinity binding to complementary sequences. They are synthesized ...
Electron detachment dissociation of fluorescently labeled sialylated oligosaccharides
(WILEY‐VCH Verlag, 2011-12)
We explored the application of electron detachment dissociation (EDD) and infrared multiphoton dissociation (IRMPD) tandem mass spectrometry to fluorescently labeled sialylated oligosaccharides. Standard sialylated ...