Now showing items 1-10 of 21
Characterization of microRNA-Protein Interactions and Genome-Scale Screening for Modifiers of LDL Cholesterol Uptake
(2020)
MicroRNAs (miRNAs) are small noncoding RNAs that regulate protein expression via post-transcriptional silencing of target genes. These small RNAs are implicated in the regulation of nearly all biological processes, and ...
ProTrack: An Interactive Multi‐Omics Data Browser for Proteogenomic Studies
(Wiley Periodicals, Inc., 2020-11)
The Clinical Proteomic Tumor Analysis Consortium (CPTAC) initiative has generated extensive multi‐omics data resources of deep proteogenomic profiles for multiple cancer types. To enable the broader community of biological ...
Comparison of Proteomic Assessment Methods in Multiple Cohort Studies
(Humana PressWiley Periodicals, Inc., 2020-06)
FRACPRED- 2D- PRM: A Fraction Prediction Algorithm- Assisted 2D Liquid Chromatography- Based Parallel Reaction Monitoring- Mass Spectrometry Approach for Measuring Low- Abundance Proteins in Human Plasma
(Wiley Periodicals, Inc., 2020-12)
Multidimensional fractionation- based enrichment methods improve the sensitivity of proteomic analysis for low- abundance proteins. However, a major limitation of conventional multidimensional proteomics is the extensive ...
3Rs‐friendly approach to exogenous metabolic activation that supports high‐throughput genetic toxicology testing
(John Wiley & Sons, Inc., 2020-04)
MultiFlow® DNA Damage—p53, γH2AX, Phospho‐Histone H3 is a miniaturized, flow cytometry‐based assay that provides genotoxic mode of action information by distinguishing clastogens, aneugens, and nongenotoxicants. Work to ...
Combining sequence data from multiple studies: Impact of analysis strategies on rare variant calling and association results
(Wiley Periodicals, Inc., 2020-01)
Individual sequencing studies often have limited sample sizes and so limited power to detect trait associations with rare variants. A common strategy is to aggregate data from multiple studies. For studying rare variants, ...
The role of environmental exposures and the epigenome in health and disease
(John Wiley & Sons, Inc., 2020-01)
A Mystery of Muscle: Establishing Mechanisms of Toxicity in Polyglutamine Disease
(2022)
Polyglutamine disorders encompass nine uniformly fatal diseases for which there are no disease course altering therapies. This group of related diseases share a key source: expansion of a CAG microsatellite repeat in genes ...
Investigation of Apoptosis and Metabolism as Mechanisms of Trichloroethylene Toxicity During Pregnancy
(2020)
Trichloroethylene (TCE), an organic solvent with multiple industrial uses, is associated with adverse pregnancy outcomes in epidemiological studies. In timed-pregnant Wistar rats, TCE exposure reduces fetal weight. ...
Probing Local Atomic Environments to Model RNA Energetics and Structure
(2020)
Ribonucleic acids (RNA) are critical components of living systems. Understanding RNA structure and its interaction with other molecules is an essential step in understanding RNA-driven processes within the cell. Experimental ...