Now showing items 1231-1236 of 1236
The Evolution of Gene Regulation in Drosophila.
(2014)
Differences in gene expression drive phenotypic diversity. At the level of transcription, these differences are largely controlled by the complex interplay between trans-acting factors and the cis-regulatory sequences to ...
Pleiotropic Effects of Cis- And Trans-Regulatory Mutations
(2021)
Changes in gene expression are an important source of phenotypic diversity both within and between species. Mutations generating variation in gene expression can be cis-regulatory to a particular gene, which typically occur ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
The Application of Genetic, In Silico and In Vitro Tools to Elucidate the Biology of a Functional Amyloid Fiber.
(2010)
Curli are thin aggregative fimbriae produced by many Enterobacteriaceae as a structural component of biofilms. Curli share many biochemical and biophysical properties with amyloid fibers which are often associated with ...
Directed Evolution Designed to Optimize the in vivo Protein Folding Environment.
(2010)
Protein folding is assisted by molecular chaperones and folding catalysts in vivo. Understanding how chaperones are regulated and how they function in vivo may provide new avenues for developing protein folding modulators. ...
Rapid Evolution of cis-Regulatory Architecture and Activity in the Drosophila Yellow Gene.
(2012)
In the last 10 years, an increasing number of case studies showed that changes in cis-regulatory elements, mainly enhancers, are one of the main causes of altered phenotypes, but the mechanisms underlying enhancer evolution ...