Now showing items 4631-4640 of 4800
Role of Hedgehog Signaling in Olfactory Epithelium Regeneration
(2022)
The olfactory epithelium (OE) lines the nasal cavities and is responsible for smell (odorant) sensation. Specialized neurons called olfactory sensory neurons (OSNs) bind to odorant molecules and transduce the smell signal ...
The Ins and Outs of Melanopsin Signaling
(2020)
Intrinsically photosensitive retinal ganglion cells (ipRGCs) are responsible for non-image-forming functions such as circadian photoentrainment, pupillary light reflex and the suppression of melatonin. Additionally, their ...
Dynamics and Regulation of Cytoskeletal Proteins
(2019)
In this dissertation, I apply molecular dynamics (MD) simulations to improve our understanding of the dynamics, and hence, function and regulation of cytoskeletal proteins. Microtubules and kinesin motor proteins play a ...
Gap Junction Protein Connexin 43 - an Unexpected Regulator of Brain Endothelial Permeability in Familial Cerebral Cavernous Malformations Type III
(2017)
Familial Cerebral Cavernous Malformations type III (fCCM3) is a disease of the cerebrovascular system caused by loss-of-function mutations in pdcd10 (ccm3) that result in dilated capillary beds susceptible to hemorrhage. ...
Single-Cell Profiling of Paracrine Network and Immune Landscape in Non-Alcoholic Steatohepatitis
(2022)
The liver is a heterogeneous organ comprising a diverse array of cells including parenchymal hepatocytes, and non-parenchymal cells (NPCs) including endothelial cells, hepatic stellate cells, cholangiocytes, and various ...
PSM Small Peptide Toxins Form Functional Bacterial Amyloids in the Staphylococcus aureus Biofilm Matrix.
(2014)
Staphylococcus aureus is a Gram-positive opportunistic pathogen colonizing mammalian hosts. Like many bacteria, S. aureus forms multicellular aggregates called biofilms. Biofilms are surface-associated communities of ...
Gene Expression and DNA Methylation in Human Placental Cell Types: Applications to Deconvolution, Prenatal Metals Exposure, and Preeclampsia Molecular Epidemiology
(2023)
The human placenta mediates adverse perinatal outcomes and current research examines molecular changes in bulk placental tissue. However, bulk molecular measures represent a convolution of signals across cell types, obscuring ...
Intersection Between RNA Methylation and TDP43-Mediated Toxicity in ALS
(2022)
Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease characterized by progressive loss of motor neurons that results in muscle loss, paralysis, and respiratory failure. ALS diagnosis is complicated ...
Retroactivity to the Output of Transcription Devices: Quantification and Insulation.
(2012)
Traditional engineering often relies on hierarchical design techniques to build com-
plex systems from simpler subsystems. This technique requires modularity, a prop-
erty that states that the input/output characteristics ...
Meox1 Regulates Proliferation and Metastasis of Drug Resistant P53 and PTEN Deficient Triple Negative Breast Cancer Offering a Specific Therapeutic Target
(2018)
Relative to other breast cancer subtypes, triple negative breast cancer (TNBC) exhibits more aggressive clinical behavior and poorer patient outcome. Lacking specified targets to improve long-term patient outcome of overall ...