Now showing items 1-10 of 24
A Systematic Informatics Approach to Synthetic Chemistry
(2023)
The navigation of chemical space through synthesis is a core principle behind drug discovery. Traditional medicinal chemistry programs rely on a few, well-developed reactivities to create pharmacophore derivatives and ...
Heterogeneous Electrocatalysts for Aqueous Nitrate Reduction and Nitrogen Chemistry
(2023)
Humans contribute more fixed nitrogen than can be reduced naturally. Understanding nitrogen chemistry is essential to balancing the global nitrogen cycle. An imbalanced nitrogen cycle raises levels of nitrate (NO3–) in ...
Computational Study of Plant Cell Wall Synthases
(2023)
This work combines a range of techniques in the field of computational biology to address both longstanding and more recent questions of plant biology, and contributes additional tools when the current options are ...
Computational and Phenomenological Modeling of Atomic-Scale Transport Processes in Glasses and Glass-Forming Liquids
(2023)
This work focuses on the computational investigation and phenomenological model development of atomic-scale transport properties in glasses and glass forming liquids. Specifically, we study ion diffusion and viscous processes ...
Development of Modular, Droplet Microfluidic Workflows to Investigate Cellular Heterogeneity
(2023)
Cells exist in unique contexts within a population, but miniscule differences in their environment, epigenome, and cell cycle produce an assortment of observable characteristics in cells. Conventional cellular analysis ...
Generation and Rearrangement of Thioethers for Self-Reinforcing Thermosets and Semi-crystalline Thermoplastic Photopolymers
(2023)
In an effort toward long-term sustainability of plastics, the development of robust polymeric materials with longer lifespans is required. The life cycle of polymeric materials can be expanded by programming polymers with ...
Bioinspired Manufacturing: Photoinduced Self-Replication of Metal Nanoparticles in Solution and on Surfaces
(2023)
Self-replication and self-assembly are two processes essential for biological systems. Their ex-vivo reproduction continuously fuels fundamental scientific discoveries and can be essential for sustainable manufacturing. ...
Development of Scalable Pathways for Addressing Constraints of Emerging Manufacturing Processes
(2023)
The goal of this Ph.D. study was to apply first-principle physics, computational fluid dynamic (CFD) simulation, scientific experimentation, model development and process design to develop scalable pathways for addressing ...
Characterizing and Utilizing Droplet-enabled Co-cultivation to Elucidate Interactions in Microbiomes
(2023)
Microbiomes, the collective communities of microorganisms in a particular habitat, play critical roles in host-associated, natural, and built environments. The cell-cell interactions in microbiomes form expansive and complex ...
Multi-Parameter Optimization of Stapled Peptides and Other Proteins Via Directed Evolution
(2023)
There is a wealth of disease-related proteins that are ‘undruggable’ by common therapeutic modalities, owing to their difficult location within cells and lacking specific structural motifs that facilitate specific targeting. ...