Now showing items 861-870 of 926
Relative impact of indels versus SNPs on complex disease
(Wiley Periodicals, Inc., 2019-02)
It is unclear whether insertions and deletions (indels) are more likely to influence complex traits than abundant single‐nucleotide polymorphisms (SNPs). We sought to understand which category of variation is more likely ...
Stereoselective β‐Mannosylation via Anomeric O‐Alkylation with L‐Sugar‐Derived Electrophiles
(Wiley Periodicals, Inc., 2021-12-28)
A total synthesis of the trisaccharide repeat unit of Salmonella serogroup E1 O‐antigen is reported. This synthesis features a key β‐mannosylation reaction through a cesium carbonate‐mediated anomeric O‐alkylation of a ...
Protein inter- residue contact and distance prediction by coupling complementary coevolution features with deep residual networks in CASP14
(John Wiley & Sons, Inc., 2021-12)
This article reports and analyzes the results of protein contact and distance prediction by our methods in the 14th Critical Assessment of techniques for protein Structure Prediction (CASP14). A new deep learning- based ...
Protein structure prediction using deep learning distance and hydrogen‐bonding restraints in CASP14
(John Wiley & Sons, Inc., 2021-12)
In this article, we report 3D structure prediction results by two of our best server groups (“Zhang‐Server” and “QUARK”) in CASP14. These two servers were built based on the D‐I‐TASSER and D‐QUARK algorithms, which integrated ...
Use of a mobile app to capture supplemental health information during pregnancy: Implications for clinical research
(John Wiley & Sons, Inc., 2022-01)
PurposeMobile applications (- apps- ) may be efficient tools for improving the quality of clinical research among pregnant women, but evidence is sparse. We assess the feasibility and generalizability of a mobile app for ...
Facile Fabrication of Anisotropic Multicompartmental Microfibers Using Charge Reversal Electrohydrodynamic Co‐Jetting
(Wiley Periodicals, Inc., 2022-01)
Anisotropic microstructures are utilized in various fields owing to their unique properties, such as reversible shape transitions or on‐demand and sequential release of drug combinations. In this study, anisotropic ...
Curcumin downregulates the PI3K–AKT–mTOR pathway and inhibits growth and progression in head and neck cancer cells
(John Wiley & Sons, Ltd., 2020-12)
Curcumin, a polyphenol isolated from the rhizome of Curcuma longa, has been studied because of its antioxidant, antimicrobial, and antiinflammatory properties. This study aimed to evaluate the effects of curcumin on head ...
Multifunctional Synthetic Protein Nanoparticles via Reactive Electrojetting
(Wiley Periodicals, Inc., 2020-12)
Protein nanoparticles are a promising approach for nanotherapeutics, as proteins combine versatile chemical and biological function with controlled biodegradability. In this work, the development of an adaptable synthesis ...
Murine adenoviruses: tools for studying adenovirus pathogenesis in a natural host
(Academic PressWiley Periodicals, Inc., 2019-12)
Fluid shear stress stimulates breast cancer cells to display invasive and chemoresistant phenotypes while upregulating PLAU in a 3D bioreactor
(Wiley Periodicals, Inc., 2019-11)
Breast cancer cells experience a range of shear stresses in the tumor microenvironment (TME). However most current in vitro three‐dimensional (3D) models fail to systematically probe the effects of this biophysical stimuli ...