Now showing items 11-20 of 69
Thiosemicarbazones of 2-acetylpyridine, 2-acetylquinoline, 1-acetylisoquinoline, and related compounds as inhibitors of herpes simplex virus in vitro and in a cutaneous herpes guinea pig model
(Elsevier, 1986-07)
A series of 111 thiosemicarbazones of 2-acetylpyridine, 2-acetylquinoline, 1-acetylisoquinoline, and related compounds were evaluated as inhibitors of herpes simplex virus in vitro and in a cutaneous herpes guinea pig ...
Anticonvulsant effects of mu (DAGO) and delta (DPDPE) enkephalins in rats
(Elsevier, 1988)
The effects of highly selective mu and delta opioid peptide agonists were determined in two rat models of experimentally-induced convulsions, the flurothyl threshold test and the maximal electroshock test. Intracerebroventricular ...
A convenient synthesis of substituted [gamma]-pyrones
(Elsevier, 1980)
An efficient and general synthetic method for various 2-mono- and 2,6-disubstituted [gamma]-pyrones has been developed. This utilizes the -acylation (70-85%) of [beta]-methoxy-[alpha],[beta]-enone lithium enolates by acid ...
Biological activities and modes of action of 9-[alpha]--arabinofuranosyladenine and 9-[alpha]--arabinofuranosyl-8-azaadenine
(Elsevier, 1981-08-15)
From earlier studies it is known that 9-[alpha]--arabinofuranosyladenine ([alpha]-araA) and 9-[alpha]--arabinofuranosyl-8-azaadenine ([alpha]-ara-8-azaA) bave in vitro antiviral activity, are cytotoxic, and are metabolized ...
Non-biomimetic route to deoxyadenosine adducts of carcinogenic polycyclic aromatic hydrocarbons
(Elsevier, 1991-10-21)
Aminotriols are prepared by direct aminolysis of the diol epoxides of polycyclic aromatic hydrocarbons, providing a substantial improvement over literature methods. The condensation of aminotriols with 6-halopurine ...
A pH- and ionic strength-responsive polypeptide hydrogel: Synthesis, characterization, and preliminary protein release studies
(John Wiley & Sons, Inc., 1999-12-15)
A novel polypeptide hydrogel has been synthesized by crosslinking poly(L-glutamic acid) (PLG) with poly(ethylene glycol) (PEG). The PLG-PEG hydrogel was shown to be highly hydrophilic, and the extent of swelling varied ...
Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae
(Springer-Verlag, 2006-02-22)
Tylosin polyketide synthase (Tyl PKS) was heterologously expressed in an engineered strain of Streptomyces venezuelae bearing a deletion of pikromycin PKS gene cluster using two compatible low-copy plasmids, each under the ...
Biotransformation of 9-[beta]-d-arabinofurano-syladenine by rat and human erythrocytes
(Elsevier, 1974-10-01)
Studies were performed to test whether 9-[beta]--arabinofuranosyladenine (ara-A) would accumulate in erythrocytes as a result of phosphorylation to the nucleotide level. When [3H]ara-A was incubated with whole blood from ...